Gallium Nitrate

drug-information.ru

|Gallium Nitrate

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Gallium Nitrate

Pronouncation: (GAL-ee-uhm NYE-trate)
Class: Hypocalcemic agent

Trade Names:
Ganite
- Injection 25 mg/mL

Mechanism of Action

Pharmacology

Exerts hypocalcemic effect by inhibiting calcium resorption from bone, possibly by stabilizing bone matrix, thereby reducing increased bone turnover.

Pharmacokinetics

Absorption

Steady state is achieved in 24 to 48 hr.

Distribution

Vd is 1.27 L/kg.

Elimination

Plasma Cl is 0.12 to 0.2 L/hr/kg. The t ½ is 24 to 115 hr. Major route of elimination is kidney.

Duration

Median is 6 to 8 days.

Indications and Usage

Treatment of symptomatic, cancer-related hypercalcemia unresponsive to adequate hydration.

Contraindications

Severe renal impairment (serum creatinine more than 2.5 mg/dL).

Dosage and Administration

Adults

IV 100 to 200 mg/m 2 /day for 5 consecutive days.

General Advice

  • For IV infusion only. Not for IV bolus, intradermal, subcutaneous, IM, or intra-arterial administration.
  • Dilute prescribed dose in 1 L 0.9% sodium chloride injection or 5% dextrose injection.
  • Infuse over 24 hr using infusion control device.
  • Do not administer if particulate matter or cloudiness is noted.
  • Discard unused portions of vial. Do not save any unused portions for future use.

Storage/Stability

Store unopened vials at controlled room temperature (68° to 77°F). Diluted solutions can be stored for up to 48 hr at ambient room temperature (59° to 86°F) or 7 days if stored under refrigeration (36° to 46°F).

Drug Interactions

Nephrotoxic drugs (eg, aminoglycosides, amphotericin B)

May increase risk for development of renal insufficiency.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Tachycardia; lower extremity edema; asymptomatic hypotension.

CNS

Lethargy, confusion, dreams, hallucinations, paresthesia.

EENT

Acute optic neuritis; visual impairment; tinnitus; decreased hearing.

GI

Nausea or vomiting; diarrhea; constipation.

Genitourinary

Increased BUN and creatinine (13%); acute renal failure.

Hematologic

Anemia; leukopenia.

Metabolic

Mild to moderate transient hypophosphatemia (79%); decreased serum bicarbonate concentrations (50%); hypocalcemia.

Respiratory

Shortness of breath; rales and rhonchi; pleural effusion; pulmonary infiltrates.

Miscellaneous

Hypothermia; fever; skin rash.

Precautions

Warnings

Concomitant use of gallium nitrate and potentially nephrotoxic drugs (eg, aminoglycosides, amphotericin B) may increase the risk for developing severe renal insufficiency in patients with cancer-related hypocalcemia. If use of potentially nephrotoxic drugs is indicated, discontinue gallium and continue hydration for several days after administration of the potentially nephrotoxic agent.


Monitor

Calcium/Phosphorous

During therapy, ensure that serum calcium and phosphorous is determined before starting therapy and then daily for calcium, and twice weekly for phosphorous. If direct measurement of free-ionized calcium is not available, measure serum albumin concentration and correct serum calcium.

Hypercalcemia symptoms

Frequently assess patient for signs or symptoms of hypercalcemia (eg, anorexia, lethargy, fatigue, nausea, vomiting, constipation, impaired mental status) and hypocalcemia (eg, muscle cramps, positive Chvostek or Trousseau sign, paraesthesia of lips or extremities). Be prepared to discontinue gallium infusion and administer calcium supplement if hypocalcemia develops.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Renal Function

Hypercalcemia in cancer patients is commonly associated with impaired renal function. Evaluate renal function (BUN, creatinine) before starting therapy and frequently during therapy.

Asymptomatic or mild to moderate hypocalcemia

Occurs frequently.

Hydration

Ensure that patient is adequately hydrated using oral and/or IV fluids (preferably saline) and that a satisfactory urine output (eg, 2 L/day) is established before beginning therapy. Ensure that adequate hydration is maintained during therapy but avoid overhydration in patient with compromised CV function.

Visual and auditory disturbances

Acute optic neuritis and decreased hearing have occurred in some patients treated with multiple high doses of gallium combined with investigational anticancer drugs.

Overdosage

Symptoms

Nausea, vomiting, renal insufficiency.

Patient Information

  • Explain name, action, and potential side effects of drug.
  • Advise patient or caregiver that medication will be prepared and administered by health care provider in a health care setting.
  • Review dosing schedule with patient or caregiver.
  • Advise patient to report any of the following to health care provider: abnormal dreams, chills, difficulty breathing, fast heartbeat, hallucinations, change in vision or hearing, weakness, mouth sores, muscle cramps or spasms, numbness or tingling around lips, abnormal skin sensations, confusion, constipation or diarrhea, swelling of ankles or feet, nausea, vomiting, rash.




Where can I get more information about Gallium Nitrate ? We recommend to use www.Drugs.com

Typical mistypes for Gallium Nitrate
fallium nitrate, vallium nitrate, ballium nitrate, hallium nitrate, yallium nitrate, tallium nitrate, gzllium nitrate, gsllium nitrate, gwllium nitrate, gqllium nitrate, gaklium nitrate, gaplium nitrate, gaolium nitrate, galkium nitrate, galpium nitrate, galoium nitrate, galluum nitrate, galljum nitrate, gallkum nitrate, galloum nitrate, gall9um nitrate, gall8um nitrate, galliym nitrate, gallihm nitrate, gallijm nitrate, galliim nitrate, galli8m nitrate, galli7m nitrate, galliun nitrate, galliuk nitrate, galliuj nitrate, gallium bitrate, gallium mitrate, gallium jitrate, gallium hitrate, gallium nutrate, gallium njtrate, gallium nktrate, gallium notrate, gallium n9trate, gallium n8trate, gallium nirrate, gallium nifrate, gallium nigrate, gallium niyrate, gallium ni6rate, gallium ni5rate, gallium niteate, gallium nitdate, gallium nitfate, gallium nittate, gallium nit5ate, gallium nit4ate, gallium nitrzte, gallium nitrste, gallium nitrwte, gallium nitrqte, gallium nitrare, gallium nitrafe, gallium nitrage, gallium nitraye, gallium nitra6e, gallium nitra5e, gallium nitratw, gallium nitrats, gallium nitratd, gallium nitratr, gallium nitrat4, gallium nitrat3, allium nitrate, gllium nitrate, galium nitrate, galium nitrate, gallum nitrate, gallim nitrate, galliu nitrate, galliumnitrate, gallium itrate, gallium ntrate, gallium nirate, gallium nitate, gallium nitrte, gallium nitrae, gallium nitrat, agllium nitrate, glalium nitrate, galilum nitrate, galluim nitrate, gallimu nitrate, galliu mnitrate, galliumn itrate, gallium intrate, gallium ntirate, gallium nirtate, gallium nitarte, gallium nitrtae, gallium nitraet, ggallium nitrate, gaallium nitrate, galllium nitrate, galllium nitrate, galliium nitrate, galliuum nitrate, galliumm nitrate, gallium nitrate, gallium nnitrate, gallium niitrate, gallium nittrate, gallium nitrrate, gallium nitraate, gallium nitratte, gallium nitratee, etc.


© Copyright by drug-information.ru 2001-2012. All rights reserved