Fluconazole Solution

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Fluconazole Solution


Generic Name: Fluconazole Injection Solution (flew-KON-ah-zole)
Brand Name: Diflucan

Fluconazole Solution is used for:

Treating and preventing certain yeast and fungal infections. Fluconazole Solution may also be used for certain conditions as determined by your doctor that may not be listed in the professional package insert.

Fluconazole Solution is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Fluconazole Solution if:

  • you are allergic to any ingredient in Fluconazole Solution
  • you are currently taking serotonin (5-HT1) receptor agonists (eg, sumatriptan), cisapride, ergot alkaloids (eg, ergotamine), erythromycin, antihistamines (eg, astemizole, terfenadine), or pimozide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fluconazole Solution:

Some medical conditions may interact with Fluconazole Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are immunocompromised or have liver or kidney problems
  • if you have allergies to other azole antifungals (eg, itraconazole)

Some MEDICINES MAY INTERACT with Fluconazole Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Rifampin because its effectiveness and the effectiveness of Fluconazole Solution may be decreased
  • Warfarin because risk of bleeding may be increased
  • Antihistamines (eg, terfenadine), cisapride, ergot alkaloids (eg, ergotamine), pimozide, serotonin receptor agonists (eg, sumatriptan), theophyllines, tricyclic antidepressants (eg, amitriptyline), macrolides (eg, erythromycin, tacrolimus), or quinolones (eg, ciprofloxacin), because risk of severe heart effects may be increased
  • Methadone, narcotics (eg, morphine, codeine), or benzodiazepines (eg, alprazolam), because actions and side effects of these medicines may be increased, resulting in increased risk of sedation and breathing difficulties
  • Cyclosporine, phenytoin, or sulfonylureas (eg, glipizide) because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluconazole Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fluconazole Solution:

Use Fluconazole Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Fluconazole Solution is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Fluconazole Solution at home, carefully follow the injection procedures taught to you by your health care provider.
  • Fluconazole Solution comes with an additional patient information leaflet. Read it carefully.
  • To clear up your infection completely, continue using Fluconazole Solution for the full course of treatment even if you feel better in a few days. Do not miss any doses.
  • Fluconazole Solution works best if it is taken at the same time each day.
  • Do not reuse needles, syringes, or other materials. Dispose of them properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full.
  • If you miss a dose of Fluconazole Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluconazole Solution.

Important safety information:

  • Fluconazole Solution may cause dizziness, drowsiness, blurred vision, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Fluconazole Solution. Using Fluconazole Solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Fluconazole Solution has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Fluconazole Solution has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Fluconazole Solution is stopped. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes.
  • Fluconazole Solution may decrease the effectiveness of your oral contraceptive (birth control pill). To prevent pregnancy, use an additional form of birth control (eg, condoms).
  • It is important to use Fluconazole Solution for the full course of treatment. Failure to do so may decrease the effectiveness of Fluconazole Solution and may increase the risk that the bacteria/fungus will no longer be sensitive to Fluconazole Solution and will not be able to be treated by this or certain other antibiotics in the future.
  • LAB TESTS, including blood urea nitrogen and liver and kidney function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Fluconazole Solution with extreme caution in ELDERLY patients.
  • PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Fluconazole Solution during pregnancy. Fluconazole Solution is excreted in breast milk. If you are or will be breast-feeding while you are using Fluconazole Solution, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Fluconazole Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; dizziness; headache; nausea; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; pain or redness at the injection site; scaly, red skin over a large portion of the body; swollen or tender abdomen; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include changes in behavior; convulsions; hallucinations; seizures; slowed breathing.

Proper storage of Fluconazole Solution:

Store injections in glass bottles between 41 and 86 degrees F (5 and 30 degrees C), away from heat, moisture, and light. Throw away any unused portion after 2 weeks. Protect from freezing.

Store injections in plastic containers between 41 and 77 degrees F (5 and 25 degrees C), away from heat, moisture, and light. Protect from freezing. Brief exposure up to 104 degrees F (40 degrees C) will not affect the product.

Do not store in the bathroom. Keep Fluconazole Solution, as well as syringes and needles, out of the reach of children and away from pets.

General information:

  • If you have any questions about Fluconazole Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Fluconazole Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Fluconazole Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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