drug-information.ru |
|Estrogens, Synthetic Conjugated, A or B |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Estrogens, Synthetic Conjugated, A or BPronouncation: (ESS-truh-janz, sin-THE-tik KAHN-juh-gay-tuhd, A or B)Class: Estrogens Trade Names: Trade Names: Mechanism of ActionPharmacologyEstrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Circulating estrogens modulate the pituitary secretion of the gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism and estrogen replacement therapy acts to reduce the elevated levels of these hormones seen in postmenopausal women. PharmacokineticsAbsorptionWell absorbed from the GI tract. Absorbed slowly from the product over a period of several hours. DistributionWidely distributed in the body and generally found in higher concentrations in sex hormone target organs. Largely bound to sex hormone binding globulin and albumin. MetabolismMetabolized mainly in the liver (estradiol converted to estrone and both are converted to estriol, a major urinary metabolite). Estrogens undergo enterohepatic recirculation via sulfate and glucuronide conjugates in the liver, biliary secretion of conjugates into the intestine, and hydrolysis in the gut followed by reabsorption. EliminationEstradiol, estrone, and estriol are excreted in the urine along with glucuronide and sulfate conjugates. Indications and UsageTreatment of moderate to severe symptoms associated with menopause (synthetic conjugated estrogens, A or B); moderate to severe symptoms of vulvar and vaginal atrophy (synthetic conjugated estrogens, A 0.3 mg only). ContraindicationsKnown or suspected pregnancy; undiagnosed abnormal genital bleeding; known or suspected cancer of the breast (except in appropriately selected patients being treated for metastatic disease); known or suspected estrogen-dependent neoplasia; active deep vein thrombosis, pulmonary embolism, or a history of these conditions; active or recent (within the past year) arterial thromboembolic disease (eg, stroke); liver dysfunction or disease; hypersensitivity to estrogens. Dosage and AdministrationMenopauseAdults PO Synthetic conjugated estrogens, A: Start with 0.45 mg/day and titrate up to 1.25 mg/day based on response. Synthetic conjugated estrogens, B: Start with 0.3 mg/day, titrate dose based on patient response. Use the lowest effective dose for the shortest duration consistent with the treatment goals and risk. Vulvar and Vaginal AtrophyAdults PO Synthetic conjugated estrogens, A: 0.3 mg/day. General AdviceAdminister prescribed dose without regard to meals. Administer with food if GI upset occurs. Storage/StabilityStore tablets at controlled room temperature (68° to 77°F). Drug InteractionsInducers of CYP3A4 (eg, carbamazepine, phenobarbital, rifampin, St. John"s wort)Estrogen concentration may be decreased, reducing the efficacy and changing the uterine bleeding profile. Inhibitors of CYP3A4 (eg, clarithromycin, erythromycin, grapefruit juice, itraconazole, ketoconazole, ritonavir)May elevate estrogen concentrations, increasing the risk of adverse effects. Laboratory Test InteractionsAccelerated PT, PTT, and platelet aggregation time with increased clotting factor activity; increased platelets; decreased anti-factor Xa and antithrombin III; increased thyroid-binding globulin (TBG) leading to increased total circulating thyroid hormone; increased plasma HDL, reduced LDL cholesterol, and increased triglycerides; impaired glucose tolerance; reduced response to metyrapone test; increased corticosteroid binding globulin and sex hormone binding globuline. Adverse ReactionsThe following adverse reactions occurred in at least 5% of patients. CardiovascularPalpitation, vasodilation. CNSAnxiety, asthenia, depression, dizziness, headache, hypertonia, insomnia, nervousness, paresthesia, vertigo. GIAbdominal pain, constipation, diarrhea, dyspepsia, flatulence, nausea, vomiting. GenitourinaryBreast pain, dysmenorrhea, endometrial thickening, metrorrhagia, vaginitis. MetabolicPeripheral edema, weight increase. MusculoskeletalArthralgia, leg cramps, myalgia. RespiratoryBronchitis, cough, pharyngitis, rhinitis, sinusitis, upper respiratory infection. MiscellaneousAccidental injury, back pain, fever, flu syndrome, infection, pain, rash. Precautions
PregnancyContraindicated in pregnancy. LactationExcreted in breast milk. May reduce quantity and quality of breast milk. ChildrenSafety not established. Special Risk PatientsBecause asthma, diabetes mellitus, epilepsy, migraine, porphyria, systemic lupus erythematosus, and hepatic hemangiomas may be exacerbated by estrogens, use with caution. Breast cancerUse of estrogens and progestins by postmenopausal women has been reported to increase the risk of breast cancer. Use of estrogen plus progestin has been reported to result in an increase in abnormal mammograms requiring further evaluation. CV disordersEstrogen and estrogen/progestin therapy has been associated with an increased risk of CV events (eg, MI, stroke, venous thromboembolism, pulmonary embolism). In the Women"s Health Initiative (WHI) study, an increase in number of strokes and venous thromboembolism has been observed in women taking conjugated estrogens compared with placebo. In addition, in women taking conjugated estrogens/medroxyprogesterone acetate an increased risk of coronary heart disease events was observed in the first year and an increase in stroke was observed after the first year. Both persisted. Cholestatic jaundice historyUse with caution and discontinue if there is recurrence. DementiaIn the WHI study, the risk of dementia was increased in women receiving conjugated estrogens/medroxyprogesterone acetate. Elevated BPSubstantial increases in BP have been attributed to idiosyncratic reactions to estrogens. Assess BP at beginning of therapy and periodically during treatment. Notify health care provider of significant increases. Endometrial cancerUse of unopposed estrogens in women with intact uteri has been associated with an increased risk of endometrial cancer. Use of estrogen plus progestin has been reported to reduce the risk of endometrial hyperplasia, which is a precursor to endometrial cancer. EndometriosisMay be exacerbated with administration of estrogens. Fluid retentionBecause estrogens may cause fluid retention, carefully monitor patients with conditions influenced by fluid retention (eg, cardiac or renal dysfunction). GallbladderIncreased risk of gallbladder disease requiring surgery. Glucose intoleranceMonitor blood sugar in diabetic patient when drug is started or dose is changed. Report significant changes to health care provider. A worsening of glucose tolerance has occurred. HypercalcemiaEstrogen administration may lead to severe hypercalcemia in patients with breast cancer and bone metastases. HypertriglyceridemiaIn patients with pre-existing hypertriglyceridemia, estrogen therapy may be associated with elevations in plasma triglycerides, leading to pancreatitis and other complications. HypocalcemiaUse with caution. HypothyroidismEstrogen administration leads to increased thyroid-binding globulin levels. Ensure thyroid function is periodically monitored in patient with hypothyroidism, and thyroid replacement dose is adjusted, if necessary, to maintain free thyroid levels in an acceptable range. Impaired liver functionEstrogens may be poorly metabolized in patients with impaired liver function. Ovarian cancerEstrogen plus progestin has been reported to increase the risk of cancer. Surgery/ImmobilizationConsider discontinuing therapy during periods of prolonged immobilization and, if possible, 4 to 6 wk before surgery that is associated with an increased risk of thromboembolic disease. Tapering/WithdrawalEnsure attempts are made q 3 to 6 mo to discontinue therapy or reduce the dose of medication Visual abnormalitiesRetinal vascular thrombosis may occur, leading to loss of vision, sudden onset of proptosis, diplopia, or migraine. Patient Information
Where can I get more information about Estrogens, Synthetic Conjugated, A or B ? We recommend to use www.Drugs.com Typical mistypes for Estrogens, Synthetic Conjugated, A or B wstrogens, synthetic conjugated, a or b, sstrogens, synthetic conjugated, a or b, dstrogens, synthetic conjugated, a or b, rstrogens, synthetic conjugated, a or b, 4strogens, synthetic conjugated, a or b, 3strogens, synthetic conjugated, a or b, eatrogens, synthetic conjugated, a or b, eztrogens, synthetic conjugated, a or b, extrogens, synthetic conjugated, a or b, edtrogens, synthetic conjugated, a or b, eetrogens, synthetic conjugated, a or b, ewtrogens, synthetic conjugated, a or b, esrrogens, synthetic conjugated, a or b, esfrogens, synthetic conjugated, a or b, esgrogens, synthetic conjugated, a or b, esyrogens, synthetic conjugated, a or b, es6rogens, synthetic conjugated, a or b, es5rogens, synthetic conjugated, a or b, esteogens, synthetic conjugated, a or b, estdogens, synthetic conjugated, a or b, estfogens, synthetic conjugated, a or b, esttogens, synthetic conjugated, a or b, est5ogens, synthetic conjugated, a or b, est4ogens, synthetic conjugated, a or b, estrigens, synthetic conjugated, a or b, estrkgens, synthetic conjugated, a or b, estrlgens, synthetic conjugated, a or b, estrpgens, synthetic conjugated, a or b, estr0gens, synthetic conjugated, a or b, estr9gens, synthetic conjugated, a or b, estrofens, synthetic conjugated, a or b, estrovens, synthetic conjugated, a or b, estrobens, synthetic conjugated, a or b, estrohens, synthetic conjugated, a or b, estroyens, synthetic conjugated, a or b, estrotens, synthetic conjugated, a or b, estrogwns, synthetic conjugated, a or b, estrogsns, synthetic conjugated, a or b, estrogdns, synthetic conjugated, a or b, estrogrns, synthetic conjugated, a or b, estrog4ns, synthetic conjugated, a or b, estrog3ns, synthetic conjugated, a or b, estrogebs, synthetic conjugated, a or b, estrogems, synthetic conjugated, a or b, estrogejs, synthetic conjugated, a or b, estrogehs, synthetic conjugated, a or b, estrogena, synthetic conjugated, a or b, estrogenz, synthetic conjugated, a or b, estrogenx, synthetic conjugated, a or b, estrogend, synthetic conjugated, a or b, estrogene, synthetic conjugated, a or b, estrogenw, synthetic conjugated, a or b, estrogens, aynthetic conjugated, a or b, estrogens, zynthetic conjugated, a or b, estrogens, xynthetic conjugated, a or b, estrogens, dynthetic conjugated, a or b, estrogens, eynthetic conjugated, a or b, estrogens, wynthetic conjugated, a or b, estrogens, stnthetic conjugated, a or b, estrogens, sgnthetic conjugated, a or b, estrogens, shnthetic conjugated, a or b, estrogens, sunthetic conjugated, a or b, estrogens, s7nthetic conjugated, a or b, estrogens, s6nthetic conjugated, a or b, estrogens, sybthetic conjugated, a or b, estrogens, symthetic conjugated, a or b, estrogens, syjthetic conjugated, a or b, estrogens, syhthetic conjugated, a or b, estrogens, synrhetic conjugated, a or b, estrogens, synfhetic conjugated, a or b, estrogens, synghetic conjugated, a or b, estrogens, synyhetic conjugated, a or b, estrogens, syn6hetic conjugated, a or b, estrogens, syn5hetic conjugated, a or b, estrogens, syntgetic conjugated, a or b, estrogens, syntbetic conjugated, a or b, estrogens, syntnetic conjugated, a or b, estrogens, syntjetic conjugated, a or b, estrogens, syntuetic conjugated, a or b, estrogens, syntyetic conjugated, a or b, estrogens, synthwtic conjugated, a or b, estrogens, synthstic conjugated, a or b, estrogens, synthdtic conjugated, a or b, estrogens, synthrtic conjugated, a or b, estrogens, synth4tic conjugated, a or b, estrogens, synth3tic conjugated, a or b, estrogens, syntheric conjugated, a or b, estrogens, synthefic conjugated, a or b, estrogens, synthegic conjugated, a or b, estrogens, syntheyic conjugated, a or b, estrogens, synthe6ic conjugated, a or b, estrogens, synthe5ic conjugated, a or b, estrogens, synthetuc conjugated, a or b, estrogens, synthetjc conjugated, a or b, estrogens, synthetkc conjugated, a or b, estrogens, synthetoc conjugated, a or b, estrogens, synthet9c conjugated, a or b, estrogens, synthet8c conjugated, a or b, estrogens, synthetix conjugated, a or b, estrogens, synthetiv conjugated, a or b, estrogens, synthetif conjugated, a or b, estrogens, synthetid conjugated, a or b, estrogens, synthetic xonjugated, a or b, estrogens, synthetic vonjugated, a or b, estrogens, synthetic fonjugated, a or b, estrogens, synthetic donjugated, a or b, estrogens, synthetic cinjugated, a or b, estrogens, synthetic cknjugated, a or b, estrogens, synthetic clnjugated, a or b, estrogens, synthetic cpnjugated, a or b, estrogens, synthetic c0njugated, a or b, estrogens, synthetic c9njugated, a or b, estrogens, synthetic cobjugated, a or b, estrogens, synthetic comjugated, a or b, estrogens, synthetic cojjugated, a or b, estrogens, synthetic cohjugated, a or b, estrogens, synthetic conhugated, a or b, estrogens, synthetic connugated, a or b, estrogens, synthetic conmugated, a or b, estrogens, synthetic conkugated, a or b, estrogens, synthetic coniugated, a or b, estrogens, synthetic conuugated, a or b, estrogens, synthetic conjygated, a or b, estrogens, synthetic conjhgated, a or b, estrogens, synthetic conjjgated, a or b, estrogens, synthetic conjigated, a or b, estrogens, synthetic conj8gated, a or b, estrogens, synthetic conj7gated, a or b, estrogens, synthetic conjufated, a or b, estrogens, synthetic conjuvated, a or b, estrogens, synthetic conjubated, a or b, estrogens, synthetic conjuhated, a or b, estrogens, synthetic conjuyated, a or b, estrogens, synthetic conjutated, a or b, estrogens, synthetic conjugzted, a or b, estrogens, synthetic conjugsted, a or b, estrogens, synthetic conjugwted, a or b, estrogens, synthetic conjugqted, a or b, estrogens, synthetic conjugared, a or b, estrogens, synthetic conjugafed, a or b, estrogens, synthetic conjugaged, a or b, estrogens, synthetic conjugayed, a or b, estrogens, synthetic conjuga6ed, a or b, estrogens, synthetic conjuga5ed, a or b, estrogens, synthetic conjugatwd, a or b, estrogens, synthetic conjugatsd, a or b, estrogens, synthetic conjugatdd, a or b, estrogens, synthetic conjugatrd, a or b, estrogens, synthetic conjugat4d, a or b, estrogens, synthetic conjugat3d, a or b, estrogens, synthetic conjugates, a or b, estrogens, synthetic conjugatex, a or b, estrogens, synthetic conjugatec, a or b, estrogens, synthetic conjugatef, a or b, estrogens, synthetic conjugater, a or b, estrogens, synthetic conjugatee, a or b, estrogens, synthetic conjugated, z or b, estrogens, synthetic conjugated, s or b, estrogens, synthetic conjugated, w or b, estrogens, synthetic conjugated, q or b, estrogens, synthetic conjugated, a ir b, estrogens, synthetic conjugated, a kr b, estrogens, synthetic conjugated, a lr b, estrogens, synthetic conjugated, a pr b, estrogens, synthetic conjugated, a 0r b, estrogens, synthetic conjugated, a 9r b, estrogens, synthetic conjugated, a oe b, estrogens, synthetic conjugated, a od b, estrogens, synthetic conjugated, a of b, estrogens, synthetic conjugated, a ot b, estrogens, synthetic conjugated, a o5 b, estrogens, synthetic conjugated, a o4 b, estrogens, synthetic conjugated, a or v, estrogens, synthetic conjugated, a or n, estrogens, synthetic conjugated, a or h, estrogens, synthetic conjugated, a or g, strogens, synthetic conjugated, a or b, etrogens, synthetic conjugated, a or b, esrogens, synthetic conjugated, a or b, estogens, synthetic conjugated, a or b, estrgens, synthetic conjugated, a or b, estroens, synthetic conjugated, a or b, estrogns, synthetic conjugated, a or b, estroges, synthetic conjugated, a or b, estrogen, synthetic conjugated, a or b, estrogens synthetic conjugated, a or b, estrogens,synthetic conjugated, a or b, estrogens, ynthetic conjugated, a or b, estrogens, snthetic conjugated, a or b, estrogens, sythetic conjugated, a or b, estrogens, synhetic conjugated, a or b, estrogens, syntetic conjugated, a or b, estrogens, synthtic conjugated, a or b, estrogens, syntheic conjugated, a or b, estrogens, synthetc conjugated, a or b, estrogens, syntheti conjugated, a or b, estrogens, syntheticconjugated, a or b, estrogens, synthetic onjugated, a or b, estrogens, synthetic cnjugated, a or b, estrogens, synthetic cojugated, a or b, estrogens, synthetic conugated, a or b, estrogens, synthetic conjgated, a or b, estrogens, synthetic conjuated, a or b, estrogens, synthetic conjugted, a or b, estrogens, synthetic conjugaed, a or b, estrogens, synthetic conjugatd, a or b, estrogens, synthetic conjugate, a or b, estrogens, synthetic conjugated a or b, estrogens, synthetic conjugated,a or b, estrogens, synthetic conjugated, or b, estrogens, synthetic conjugated, aor b, estrogens, synthetic conjugated, a r b, estrogens, synthetic conjugated, a o b, estrogens, synthetic conjugated, a orb, estrogens, synthetic conjugated, a or , setrogens, synthetic conjugated, a or b, etsrogens, synthetic conjugated, a or b, esrtogens, synthetic conjugated, a or b, estorgens, synthetic conjugated, a or b, estrgoens, synthetic conjugated, a or b, estroegns, synthetic conjugated, a or b, estrognes, synthetic conjugated, a or b, estrogesn, synthetic conjugated, a or b, estrogen,s synthetic conjugated, a or b, estrogens ,synthetic conjugated, a or b, estrogens,s ynthetic conjugated, a or b, estrogens, ysnthetic conjugated, a or b, estrogens, snythetic conjugated, a or b, estrogens, sytnhetic conjugated, a or b, estrogens, synhtetic conjugated, a or b, estrogens, syntehtic conjugated, a or b, estrogens, synthteic conjugated, a or b, estrogens, syntheitc conjugated, a or b, estrogens, synthetci conjugated, a or b, estrogens, syntheti cconjugated, a or b, estrogens, syntheticc onjugated, a or b, estrogens, synthetic ocnjugated, a or b, estrogens, synthetic cnojugated, a or b, estrogens, synthetic cojnugated, a or b, estrogens, synthetic conujgated, a or b, estrogens, synthetic conjguated, a or b, estrogens, synthetic conjuagted, a or b, estrogens, synthetic conjugtaed, a or b, estrogens, synthetic conjugaetd, a or b, estrogens, synthetic conjugatde, a or b, estrogens, synthetic conjugate,d a or b, estrogens, synthetic conjugated ,a or b, estrogens, synthetic conjugated,a or b, estrogens, synthetic conjugated, aor b, estrogens, synthetic conjugated, ao r b, estrogens, synthetic conjugated, a ro b, estrogens, synthetic conjugated, a o rb, estrogens, synthetic conjugated, a orb , eestrogens, synthetic conjugated, a or b, esstrogens, synthetic conjugated, a or b, esttrogens, synthetic conjugated, a or b, estrrogens, synthetic conjugated, a or b, estroogens, synthetic conjugated, a or b, estroggens, synthetic conjugated, a or b, estrogeens, synthetic conjugated, a or b, estrogenns, synthetic conjugated, a or b, estrogenss, synthetic conjugated, a or b, estrogens,, synthetic conjugated, a or b, estrogens, synthetic conjugated, a or b, estrogens, ssynthetic conjugated, a or b, estrogens, syynthetic conjugated, a or b, estrogens, synnthetic conjugated, a or b, estrogens, syntthetic conjugated, a or b, estrogens, synthhetic conjugated, a or b, estrogens, syntheetic conjugated, a or b, estrogens, synthettic conjugated, a or b, estrogens, synthetiic conjugated, a or b, estrogens, syntheticc conjugated, a or b, estrogens, synthetic conjugated, a or b, estrogens, synthetic cconjugated, a or b, estrogens, synthetic coonjugated, a or b, estrogens, synthetic connjugated, a or b, estrogens, synthetic conjjugated, a or b, estrogens, synthetic conjuugated, a or b, estrogens, synthetic conjuggated, a or b, estrogens, synthetic conjugaated, a or b, estrogens, synthetic conjugatted, a or b, estrogens, synthetic conjugateed, a or b, estrogens, synthetic conjugatedd, a or b, estrogens, synthetic conjugated,, a or b, estrogens, synthetic conjugated, a or b, estrogens, synthetic conjugated, aa or b, estrogens, synthetic conjugated, a or b, estrogens, synthetic conjugated, a oor b, estrogens, synthetic conjugated, a orr b, estrogens, synthetic conjugated, a or b, estrogens, synthetic conjugated, a or bb, etc.
|