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|Epinastine HCl |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Epinastine HClPronouncation: (epp-ih-NAS-teen HIGH-droe-KLOR-ide)Class: Antihistamine, Ophthalmic Trade Names: Mechanism of ActionPharmacologyDirect H 1 -receptor antagonist that inhibits release of histamine from the mast cell. PharmacokineticsAbsorptionLow systemic exposure. DistributionPlasma protein binding approximately 64%. MetabolismLess than 10% metabolized. EliminationTerminal plasma elimination t ½ is about 12 hr. Mainly excreted unchanged (after IV dosing about 55% in urine and 30% in feces). Renal elimination via active tubular secretion. Indications and UsagePrevention of itching associated with allergic conjunctivitis. ContraindicationsStandard considerations. Dosage and AdministrationAdults and children 3 yr and olderOphthalmic 1 gtt in each eye bid, continuing treatment throughout the period of exposure (until pollen season is over or until exposure to offending allergen is terminated) even when symptoms are absent. General Advice
Storage/StabilityStore ophthalmic solution at controlled room temperature (59°F to 77°F). Keep tightly closed. Drug InteractionsNone well documented. Laboratory Test InteractionsNone well documented. Adverse ReactionsCNSHeadache (1% to 3%). EENTBurning sensation in eye, folliculosis, hyperemia, pruritus (1% to 10%); rhinitis, sinusitis, pharyngitis (1% to 3%). RespiratoryUpper respiratory infection (10%); increased cough (1% to 3%). MiscellaneousSymptoms of cold (10%). Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established in children under 3 yr. Patient Information
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