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|Drotrecogin Alfa |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Drotrecogin Alfa (Activated)Pronouncation: (droh-truh-KO-jin AL-fah)Class: Recombinant human activated protein C Trade Names: Mechanism of ActionPharmacologyExerts antithrombotic effect by inhibiting Factors Va and VIIIa. PharmacokineticsAbsorptionSteady-state concentration of 45 ng/mL attained within 2 hr. EliminationCl is approximately 40 L/hr. Special PopulationsSevere sepsisCl is approximately 50% higher. Dosage adjustment is not required. Indications and UsageReduction of mortality in adult patients with severe sepsis who have a high risk of death. ContraindicationsPatients with the following situations in whom bleeding could be associated with a high risk of death or significant morbidity: active internal bleeding; recent (within 3 mo) hemorrhagic stroke; recent (within 2 mo) intracranial or intraspinal surgery or severe head trauma; trauma with an increased risk of life-threatening bleeding; presence of an epidural catheter; intracranial neoplasm, mass lesion, or evidence of cerebral herniation. Hypersensitivity to drotrecogin alfa (activated) or any component of the product. Dosage and AdministrationAdultsIV 24 mcg/kg/hr for a total infusion duration of 96 hr. If infusion is interrupted, restart at the 24 mcg/kg/hr infusion rate. General Advice
Storage/StabilityIf the IV infusion solution is not administered immediately, the solution may be stored refrigerated (36° to 46°F) for up to 12 hr. If prepared solution is refrigerated prior to administration, the max time limit for use of the IV infusion solution, including preparation, refrigeration, and administration, is 24 hr. Store unreconstituted vials in refrigerator. Do not freeze. Protect unreconstituted vials from light. Retain in carton until time of use. Do not use beyond expiration date stamped on vial. Avoid exposing drotrecogin alfa solutions to heat and/or direct sunlight. Drug InteractionsAspirin, glycoprotein IIb/IIIa inhibitors, oral anticoagulants (eg, warfarin)Increased risk of bleeding. IncompatibilityAdminister through a dedicated line or dedicated lumen of a multilumen central venous catheter. Only 0.9% sodium chloride for injection, lactated Ringer"s injection, dextrose, or dextrose and saline mixtures can be administered through the same line as drotrecogin alfa. Laboratory Test InteractionsBecause drotrecogin alfa may variably prolong the APTT, APTT cannot be reliably used to assess the status of coagulopathy during drotrecogin alfa administration; drotrecogin alfa present in plasma samples may interfere with 1-stage coagulation assay based on the APTT (eg, factor VIII, IX, and XI) assays. Adverse ReactionsHematologicBleeding/hemorrhage (eg, GI, GU, intra-abdominal, intracranial, intrathoracic, retroperitoneal, skin/soft tissue, other sites). PrecautionsPregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. BleedingSevere bleeding may occur. ImmunogenicityAs with all therapeutic proteins, immunogenicity may occur. OverdosageSymptomsMonitor closely for hemorrhagic complications. Patient Information
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