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|Droperidol Droperidol |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home DroperidolPronouncation: (dro-PER-i-dahl)Class: General anesthetic Trade Names: Mechanism of ActionPharmacologyProduces tranquilization, sedation and antiemetic effects, as well as mild alpha-adrenergic blockade, resulting in hypotension and decreased peripheral vascular resistance. PharmacokineticsDistributionVd is 1.5 L/kg (at steady-state). Biphasic distribution with a t ½ of approximately 1.4 min (rapid phase) and approximately 14.3 min (slower phase). MetabolismExtensively metabolized. EliminationIMApproximately 75% excreted in the urine (1% as unchanged drug) and 22% excreted in feces. t ½ approximately 134 min. Onset3 to 10 min. Peak30 min. Duration2 to 4 hr. Indications and UsageReduction of incidence of nausea and vomiting in surgical and diagnostic procedures. Unlabeled UsesAntiemetic in cancer chemotherapy. ContraindicationsKnown or suspected QT prolongation (ie, QTc interval greater than 440 msec for men or greater than 450 msec for women), including patients with congenital long QT syndrome. Hypersensitivity to butyrophenones. Dosage and AdministrationAdultsIM or slow IV 2.5 mg max recommended initial dose; additional 1.25 mg doses may be administered to achieve desired effect. Children (2 to 12 yr)IM / IV 0.1 mg/kg max recommended initial dose, taking into account age and other clinical factors. Y-SiteCompatible when mixed in syringe with atropine, butorphanol, chlorpromazine, fentanyl, glycopyrrolate, hydroxyzine, morphine, meperidine, perphenazine, promazine, promethazine, or scopolamine. Storage/StabilityStore at room temperature and protect from light. Solution remains stable for 7 to 10 days. Drug InteractionsCNS depressantsAdditive CNS depression may result. Diuretics, drugs known to increase the QT interval (eg, cisapride, pimozide)Risk of life-threatening arrhythmias, including torsades de pointes, may be increased. IncompatibilityBarbiturates are physically incompatible with droperidol. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularQT interval prolongation; torsades de pointes; cardiac arrest; ventricular tachycardia; hypotension. CNSPostoperative drowsiness; extrapyramidal effects (eg, dystonia, akathisia and oculogyric crisis); restlessness; hyperactivity; anxiety; dizziness; postoperative hallucinations; mental depression. RespiratoryRespiratory depression; bronchospasm; laryngospasm. MiscellaneousMuscular rigidity; chills or shivering. Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy in children less than 2 yr not established. Special Risk PatientsDecreased dose may be necessary. Use drug with caution in elderly, debilitated, and hepatically or renally impaired patients. Neuroleptic malignant syndromeRare cases of neuroleptic malignant syndrome (eg, altered consciousness, muscle rigidity, autonomic instability) have been reported. OverdosageSymptomsExtension of pharmacologic effects, including QT prolongation, serious arrhythmias (eg, torsades de pointes), sedation, and hypotension. Patient Information
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