Droperidol
 Droperidol

drug-information.ru

|Droperidol Droperidol

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Droperidol

Pronouncation: (dro-PER-i-dahl)
Class: General anesthetic

Trade Names:
Inapsine
- Injection 2.5 mg/mL

Mechanism of Action

Pharmacology

Produces tranquilization, sedation and antiemetic effects, as well as mild alpha-adrenergic blockade, resulting in hypotension and decreased peripheral vascular resistance.

Pharmacokinetics

Distribution

Vd is 1.5 L/kg (at steady-state). Biphasic distribution with a t ½ of approximately 1.4 min (rapid phase) and approximately 14.3 min (slower phase).

Metabolism

Extensively metabolized.

Elimination

IM

Approximately 75% excreted in the urine (1% as unchanged drug) and 22% excreted in feces. t ½ approximately 134 min.

Onset

3 to 10 min.

Peak

30 min.

Duration

2 to 4 hr.

Indications and Usage

Reduction of incidence of nausea and vomiting in surgical and diagnostic procedures.

Unlabeled Uses

Antiemetic in cancer chemotherapy.

Contraindications

Known or suspected QT prolongation (ie, QTc interval greater than 440 msec for men or greater than 450 msec for women), including patients with congenital long QT syndrome. Hypersensitivity to butyrophenones.

Dosage and Administration

Adults

IM or slow IV 2.5 mg max recommended initial dose; additional 1.25 mg doses may be administered to achieve desired effect.

Children (2 to 12 yr)

IM / IV 0.1 mg/kg max recommended initial dose, taking into account age and other clinical factors.

Y-Site

Compatible when mixed in syringe with atropine, butorphanol, chlorpromazine, fentanyl, glycopyrrolate, hydroxyzine, morphine, meperidine, perphenazine, promazine, promethazine, or scopolamine.

Storage/Stability

Store at room temperature and protect from light. Solution remains stable for 7 to 10 days.

Drug Interactions

CNS depressants

Additive CNS depression may result.

Diuretics, drugs known to increase the QT interval (eg, cisapride, pimozide)

Risk of life-threatening arrhythmias, including torsades de pointes, may be increased.

Incompatibility

Barbiturates are physically incompatible with droperidol.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

QT interval prolongation; torsades de pointes; cardiac arrest; ventricular tachycardia; hypotension.

CNS

Postoperative drowsiness; extrapyramidal effects (eg, dystonia, akathisia and oculogyric crisis); restlessness; hyperactivity; anxiety; dizziness; postoperative hallucinations; mental depression.

Respiratory

Respiratory depression; bronchospasm; laryngospasm.

Miscellaneous

Muscular rigidity; chills or shivering.

Precautions

Warnings

Contraindications

Contraindicated in patients with known or suspected QT prolongation.

QT prolongation/torsades de pointes

Have been reported at or below recommended doses. Some cases have been in patients without known risk factors for QT prolongation. Some cases have been fatal. Perform baseline 12-lead ECG prior to initiation of therapy. Do not administer if QTc is greater than 440 msec in men or 450 msec in women. Use with extreme caution in patients at risk of developing prolonged QT syndrome (eg, CHF, bradycardia, diuretic use, cardiac hypertrophy, hypokalemia, hypomagnesemia, drugs that prolong QT interval, older than 65 yr, alcohol abuse, or taking benzodiazepines, volatile anesthetics, or IV opiates).

Refractory disease

Reserve treatment in refractory disease because of serious proarrhythmic effects.


Monitor

Monitor ECG prior to treatment and continue for 2 to 3 hr after completing treatment to monitor for arrhythmias if the potential benefit outweighs the risk of potentially serious arrhythmias. Assess patient"s respiratory status continuously. If patient is receiving narcotic analgesic concurrently, respiratory depression may occur. Note extrapyramidal symptoms.


Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy in children less than 2 yr not established.

Special Risk Patients

Decreased dose may be necessary. Use drug with caution in elderly, debilitated, and hepatically or renally impaired patients.

Neuroleptic malignant syndrome

Rare cases of neuroleptic malignant syndrome (eg, altered consciousness, muscle rigidity, autonomic instability) have been reported.

Overdosage

Symptoms

Extension of pharmacologic effects, including QT prolongation, serious arrhythmias (eg, torsades de pointes), sedation, and hypotension.

Patient Information

  • Caution patient to avoid sudden changes in position to prevent orthostatic hypotension.
  • Instruct patient to call for help before rising from bed.
  • Advise patient to avoid intake of alcoholic beverages or other CNS depressants for greater than or equal to 24 hr after treatment.




Where can I get more information about Droperidol Droperidol ? We recommend to use www.Drugs.com

Typical mistypes for Droperidol Droperidol
sroperidol droperidol, xroperidol droperidol, croperidol droperidol, froperidol droperidol, rroperidol droperidol, eroperidol droperidol, deoperidol droperidol, ddoperidol droperidol, dfoperidol droperidol, dtoperidol droperidol, d5operidol droperidol, d4operidol droperidol, driperidol droperidol, drkperidol droperidol, drlperidol droperidol, drpperidol droperidol, dr0peridol droperidol, dr9peridol droperidol, drooeridol droperidol, droleridol droperidol, dro-eridol droperidol, dro0eridol droperidol, dropwridol droperidol, dropsridol droperidol, dropdridol droperidol, droprridol droperidol, drop4ridol droperidol, drop3ridol droperidol, dropeeidol droperidol, dropedidol droperidol, dropefidol droperidol, dropetidol droperidol, drope5idol droperidol, drope4idol droperidol, droperudol droperidol, droperjdol droperidol, droperkdol droperidol, droperodol droperidol, droper9dol droperidol, droper8dol droperidol, droperisol droperidol, droperixol droperidol, dropericol droperidol, droperifol droperidol, droperirol droperidol, droperieol droperidol, droperidil droperidol, droperidkl droperidol, droperidll droperidol, droperidpl droperidol, droperid0l droperidol, droperid9l droperidol, droperidok droperidol, droperidop droperidol, droperidoo droperidol, droperidol sroperidol, droperidol xroperidol, droperidol croperidol, droperidol froperidol, droperidol rroperidol, droperidol eroperidol, droperidol deoperidol, droperidol ddoperidol, droperidol dfoperidol, droperidol dtoperidol, droperidol d5operidol, droperidol d4operidol, droperidol driperidol, droperidol drkperidol, droperidol drlperidol, droperidol drpperidol, droperidol dr0peridol, droperidol dr9peridol, droperidol drooeridol, droperidol droleridol, droperidol dro-eridol, droperidol dro0eridol, droperidol dropwridol, droperidol dropsridol, droperidol dropdridol, droperidol droprridol, droperidol drop4ridol, droperidol drop3ridol, droperidol dropeeidol, droperidol dropedidol, droperidol dropefidol, droperidol dropetidol, droperidol drope5idol, droperidol drope4idol, droperidol droperudol, droperidol droperjdol, droperidol droperkdol, droperidol droperodol, droperidol droper9dol, droperidol droper8dol, droperidol droperisol, droperidol droperixol, droperidol dropericol, droperidol droperifol, droperidol droperirol, droperidol droperieol, droperidol droperidil, droperidol droperidkl, droperidol droperidll, droperidol droperidpl, droperidol droperid0l, droperidol droperid9l, droperidol droperidok, droperidol droperidop, droperidol droperidoo, roperidol droperidol, doperidol droperidol, drperidol droperidol, droeridol droperidol, dropridol droperidol, dropeidol droperidol, droperdol droperidol, droperiol droperidol, droperidl droperidol, droperido droperidol, droperidol droperidol, droperidol droperidol, droperidol roperidol, droperidol doperidol, droperidol drperidol, droperidol droeridol, droperidol dropridol, droperidol dropeidol, droperidol droperdol, droperidol droperiol, droperidol droperidl, droperidol droperido, rdoperidol droperidol, dorperidol droperidol, drpoeridol droperidol, droepridol droperidol, dropreidol droperidol, dropeirdol droperidol, droperdiol droperidol, droperiodl droperidol, droperidlo droperidol, droperido l droperidol, droperidol droperidol, droperidol d roperidol, droperidol rdoperidol, droperidol dorperidol, droperidol drpoeridol, droperidol droepridol, droperidol dropreidol, droperidol dropeirdol, droperidol droperdiol, droperidol droperiodl, droperidol droperidlo, ddroperidol droperidol, drroperidol droperidol, drooperidol droperidol, dropperidol droperidol, dropeeridol droperidol, droperridol droperidol, droperiidol droperidol, droperiddol droperidol, droperidool droperidol, droperidoll droperidol, droperidol droperidol, droperidol droperidol, droperidol ddroperidol, droperidol drroperidol, droperidol drooperidol, droperidol dropperidol, droperidol dropeeridol, droperidol droperridol, droperidol droperiidol, droperidol droperiddol, droperidol droperidool, droperidol droperidoll, etc.



© Copyright by drug-information.ru 2001-2019. All rights reserved