drug-information.ru |
|Doxapram Hydrochloride |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Doxapram HydrochloridePronouncation: (DOX-uh-pram HIGH-droe-KLOR-ide)Class: Analeptic Trade Names: Mechanism of ActionPharmacologyIncreases depth of respirations (tidal volume) by stimulating respiratory center in CNS; respiratory rate may increase slightly. May elevate BP by increasing cardiac output. Respiratory depression from opiates is reversed without affecting pain relief. PharmacokineticsMetabolismExtensively metabolized. EliminationMetabolites and a small amount of unchanged drug excreted in urine. The t ½ is 2.4 to 4.1 hr. Onset20 to 40 sec. Peak1 to 2 min. Duration5 to 12 min. Indications and UsageStimulate deep breathing in postoperative patients; reversal of respiratory depression caused by anesthesia (other than muscle relaxants) or drug overdose; temporary measure for acute respiratory failure in patients with COPD who are not undergoing mechanical ventilation. ContraindicationsUse in newborns (contains benzyl alcohol); seizures; muscle paresis; epilepsy or other convulsive states; flail chest; head injury; pneumothorax; acute asthma; pulmonary fibrosis; other conditions that restrict chest wall, respiratory muscles or alveolar expansion; severe hypertension; cerebrovascular accident; proven or suspected pulmonary embolism; mechanical obstruction; cerebral edema; CV impairment; uncompensated heart failure; severe coronary artery disease; hypersensitivity to any component of the product. Dosage and AdministrationAnesthesia-induced Respiratory DepressionAdults Max daily dose is 3 g. Bolus IV injection 0.5 to 1 mg/kg (single dose not to exceed 1.5 mg/kg). Can be given as multiple IV injections q 5 min (not to exceed total dose of 2 mg/kg). IV infusion Initial rate 5 mg/min until satisfactory respiratory response is noted. Maintenance rate: 1 to 3 mg/min. Max total infusion dose is 4 mg/kg. Drug-induced CNS DepressionAdults Max daily dose is 3 g. Bolus IV injection Priming dose is 1 to 2 mg/kg (mild to moderate). Repeat in 5 min. Depending on response, may give q 1 to 2 hr until patient awakens. Intermittent IV infusion Priming dose is 1 to 2 mg/kg (mild to moderate). If respirations improve, give by IV infusion at 1 to 3 mg/min. Discontinue after 2 hr or if patient awakens. Acute Hypercapnia from COPDAdults IV infusion 2 mg/mL with initial rate of 1 to 2 mg/min; may increase to max 3 mg/min; discontinue after 2 hr. Storage/StabilityStore vials at controlled room temperature (59° to 86°F). Drug InteractionsAminophylline, theophyllineMay increase skeletal muscle activity, agitation, and hyperactivity. Cyclopropane, enflurane, halothaneTo prevent arrhythmias, wait at least 10 min after stopping these anesthetics before giving doxapram. MAO inhibitors, sympathomimeticsIncreased risk of hypertension. Muscle relaxantsResidual effects may be temporarily masked by doxapram. IncompatibilityDo not add to or give with alkaline solutions such as aminophylline, furosemide, thiopental, or sodium bicarbonate. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularArrhythmias; chest pain; increased BP; lowered T-waves; phlebitis; tachycardia; tightness in chest; variations in heart rate. CNSApprehension; bilateral Babinski; clonus; disorientation; dizziness; hallucination; headache; hyperactivity; increased reflexes; involuntary movements; muscle spasticity and fasciculations; paresthesia; pyrexia; seizures. EENTPupillary dilation. GIDesire to defecate; diarrhea; nausea; vomiting. GenitourinaryElevation of BUN; urinary incontinence and retention. HematologicHemolysis (with rapid infusion). RespiratoryBronchospasm; cough; dyspnea; hiccoughs; hyperventilation; laryngospasm; rebound hypoventilation; tachypnea. MiscellaneousFeelings of warmth; flushing; pruritus; sweating. PrecautionsPregnancyCategory B . LactationUndetermined. ChildrenSafety and efficacy not established in children younger than 12 yr of age. Doxapram contains benzyl alcohol, which has been associated with fatal gasping syndrome in premature infants. COPD patientsDo not increase infusion rate in severely ill patients; drug may increase work of breathing. Drug-induced CNS and respiratory depressionUsed as adjunct to supportive care. PostanesthesiaDo not use as antidote for opiates or neuromuscular blockers. OverdosageSymptomsSevere hypertension, tachycardia, hyperactive reflexes, seizures. Patient Information
Where can I get more information about Doxapram Hydrochloride ? We recommend to use www.Drugs.com Typical mistypes for Doxapram Hydrochloride soxapram hydrochloride, xoxapram hydrochloride, coxapram hydrochloride, foxapram hydrochloride, roxapram hydrochloride, eoxapram hydrochloride, dixapram hydrochloride, dkxapram hydrochloride, dlxapram hydrochloride, dpxapram hydrochloride, d0xapram hydrochloride, d9xapram hydrochloride, dozapram hydrochloride, docapram hydrochloride, dodapram hydrochloride, dosapram hydrochloride, doxzpram hydrochloride, doxspram hydrochloride, doxwpram hydrochloride, doxqpram hydrochloride, doxaoram hydrochloride, doxalram hydrochloride, doxa-ram hydrochloride, doxa0ram hydrochloride, doxapeam hydrochloride, doxapdam hydrochloride, doxapfam hydrochloride, doxaptam hydrochloride, doxap5am hydrochloride, doxap4am hydrochloride, doxaprzm hydrochloride, doxaprsm hydrochloride, doxaprwm hydrochloride, doxaprqm hydrochloride, doxapran hydrochloride, doxaprak hydrochloride, doxapraj hydrochloride, doxapram gydrochloride, doxapram bydrochloride, doxapram nydrochloride, doxapram jydrochloride, doxapram uydrochloride, doxapram yydrochloride, doxapram htdrochloride, doxapram hgdrochloride, doxapram hhdrochloride, doxapram hudrochloride, doxapram h7drochloride, doxapram h6drochloride, doxapram hysrochloride, doxapram hyxrochloride, doxapram hycrochloride, doxapram hyfrochloride, doxapram hyrrochloride, doxapram hyerochloride, doxapram hydeochloride, doxapram hyddochloride, doxapram hydfochloride, doxapram hydtochloride, doxapram hyd5ochloride, doxapram hyd4ochloride, doxapram hydrichloride, doxapram hydrkchloride, doxapram hydrlchloride, doxapram hydrpchloride, doxapram hydr0chloride, doxapram hydr9chloride, doxapram hydroxhloride, doxapram hydrovhloride, doxapram hydrofhloride, doxapram hydrodhloride, doxapram hydrocgloride, doxapram hydrocbloride, doxapram hydrocnloride, doxapram hydrocjloride, doxapram hydroculoride, doxapram hydrocyloride, doxapram hydrochkoride, doxapram hydrochporide, doxapram hydrochooride, doxapram hydrochliride, doxapram hydrochlkride, doxapram hydrochllride, doxapram hydrochlpride, doxapram hydrochl0ride, doxapram hydrochl9ride, doxapram hydrochloeide, doxapram hydrochlodide, doxapram hydrochlofide, doxapram hydrochlotide, doxapram hydrochlo5ide, doxapram hydrochlo4ide, doxapram hydrochlorude, doxapram hydrochlorjde, doxapram hydrochlorkde, doxapram hydrochlorode, doxapram hydrochlor9de, doxapram hydrochlor8de, doxapram hydrochlorise, doxapram hydrochlorixe, doxapram hydrochlorice, doxapram hydrochlorife, doxapram hydrochlorire, doxapram hydrochloriee, doxapram hydrochloridw, doxapram hydrochlorids, doxapram hydrochloridd, doxapram hydrochloridr, doxapram hydrochlorid4, doxapram hydrochlorid3, oxapram hydrochloride, dxapram hydrochloride, doapram hydrochloride, doxpram hydrochloride, doxaram hydrochloride, doxapam hydrochloride, doxaprm hydrochloride, doxapra hydrochloride, doxapramhydrochloride, doxapram ydrochloride, doxapram hdrochloride, doxapram hyrochloride, doxapram hydochloride, doxapram hydrchloride, doxapram hydrohloride, doxapram hydrocloride, doxapram hydrochoride, doxapram hydrochlride, doxapram hydrochloide, doxapram hydrochlorde, doxapram hydrochlorie, doxapram hydrochlorid, odxapram hydrochloride, dxoapram hydrochloride, doaxpram hydrochloride, doxparam hydrochloride, doxarpam hydrochloride, doxaparm hydrochloride, doxaprma hydrochloride, doxapra mhydrochloride, doxapramh ydrochloride, doxapram yhdrochloride, doxapram hdyrochloride, doxapram hyrdochloride, doxapram hydorchloride, doxapram hydrcohloride, doxapram hydrohcloride, doxapram hydroclhoride, doxapram hydrocholride, doxapram hydrochlroide, doxapram hydrochloirde, doxapram hydrochlordie, doxapram hydrochloried, ddoxapram hydrochloride, dooxapram hydrochloride, doxxapram hydrochloride, doxaapram hydrochloride, doxappram hydrochloride, doxaprram hydrochloride, doxapraam hydrochloride, doxapramm hydrochloride, doxapram hydrochloride, doxapram hhydrochloride, doxapram hyydrochloride, doxapram hyddrochloride, doxapram hydrrochloride, doxapram hydroochloride, doxapram hydrocchloride, doxapram hydrochhloride, doxapram hydrochlloride, doxapram hydrochlooride, doxapram hydrochlorride, doxapram hydrochloriide, doxapram hydrochloridde, doxapram hydrochloridee, etc.
|