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Pulmozyme, |dornase alfa inhalation Dornase Alfa

dornase alfa

Generic Name: dornase alfa (inhalation) (DOOR nase AL fa)
Brand Names: Pulmozyme

What is dornase alfa?

Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis.

Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections.

Dornase alfa may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about dornase alfa?

Ampules of dornase alfa do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded.

What should I discuss with my healthcare provider before using dornase alfa?

Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment.

How should I use dornase alfa?

Use dornase alfa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or other healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer.

If you are also taking other respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.) Do not dilute or mix dornase alfa with other agents in the nebulizer at the same time.

Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule must be used or discarded.

Dornase alfa should be used on a regular basis to get the most benefit.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and use only the next regularly scheduled dose as directed. Do not use a double dose.

What happens if I overdose?

Symptoms of a dornase alfa overdose are not known.

What should I avoid while using dornase alfa?

Dornase alfa side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• increased difficulty breathing;

• chest pain; or

• fever.

Less serious side effects may be more likely to occur with the use of dornase alfa. Talk to your doctor if you experience any of the following side effects:

• voice alteration;

• sore throat;

• rash;

• laryngitis;

• eye redness, irritation, or inflammation; or

• nasal stuffiness or discharge.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect dornase alfa?

There are no known interactions between dornase alfa and other medicines. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with dornase alfa.

Where can I get more information?

• Your pharmacist has more information about dornase alfa written for health professionals that you may read.

What does my medication look like?

Dornase alfa is available with a prescription under the brand name Pulmozyme. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Pulmozyme 2.5 mL ampules-clear, colorless solution

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.