Docetaxel

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|Docetaxel

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Docetaxel


Generic Name: Docetaxel (doe-se-TAX-el)
Brand Name: Taxotere

Docetaxel may cause severe allergic reactions, decreased ability to fight infection (weakened immune system), and severe swelling. Docetaxel should not be used by patients who have had a severe allergic reaction to Docetaxel or other medicines containing polysorbate 80. There have been a higher number of deaths related to Docetaxel when it is used in higher doses or in patients with abnormal liver function, non-small cell lung cancer, or a history of platinum-based chemotherapy treatment (eg, cisplatin). Lab tests will be required to monitor blood cell counts and liver function. Contact your doctor immediately if you develop difficulty breathing, swelling, fast heartbeat, dizziness, faintness, symptoms of an infection (eg, persistent fever, sore throat), unusual bruising or bleeding, mouth sores, or skin rash or irritation.


Docetaxel is used for:

Treating certain types of breast, prostate, non-small cell lung, or advanced stomach cancer. Docetaxel may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Docetaxel is an antineoplastic agent. It works by stopping the growth and reproduction of cancer cells in the body.

Do NOT use Docetaxel if:

  • you are allergic to any ingredient in Docetaxel or polysorbate 80
  • you have a severely low white blood cell count

Contact your doctor or health care provider right away if any of these apply to you.

Before using Docetaxel :

Some medical conditions may interact with Docetaxel . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a viral or bacterial infection (eg, chickenpox, herpes), a weakened immune system due to radiation therapy or a low white blood cell count, heart disease, an open wound in the chest wall, fluid in the lungs (pleural effusion), liver or kidney problems, or swelling of the hands or feet
  • if you drink more than 3 alcohol-containing drinks a day or are receiving radiation therapy

Some MEDICINES MAY INTERACT with Docetaxel . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cisplatin, cyclosporine, erythromycin, ketoconazole, terfenadine, or troleandomycin because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Docetaxel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Docetaxel :

Use Docetaxel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An additional patient leaflet is available with Docetaxel . Talk to your pharmacist if you have questions about this information.
  • Docetaxel is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Docetaxel at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Docetaxel contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Docetaxel , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Docetaxel .

Important safety information:

  • Docetaxel may lower your body"s ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
  • If you drink more than 3 alcohol-containing drinks a day, do not take Docetaxel without first discussing it with your doctor.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Docetaxel . Vaccinations may be less effective. Check with your doctor before having any vaccinations while you are using Docetaxel .
  • Lab tests, including white blood cell counts and liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Docetaxel with caution in the ELDERLY because they may be more sensitive to its effects.
  • Docetaxel is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Docetaxel has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Docetaxel . If you think you may be pregnant, discuss with your doctor the benefits and risks of using Docetaxel during pregnancy. It is unknown if Docetaxel is excreted in breast milk. Do not breast-feed while taking Docetaxel .

Possible side effects of Docetaxel :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in taste; diarrhea; fever; hair loss; nausea; nerve pain; pain at the injection site; red or dry skin; tearing of the eyes; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; change in appearance of nails; changes in the amount of urine; chest pain; chills; cough; difficulty swallowing; dizziness; fainting; fast, slow, or irregular heartbeat; fever; mouth sores; muscle or joint pain; rash and redness over the body; seizures; severe headache; severe pain or redness of the legs; severe stomach pain; sore throat; swelling; tightness in the lungs; unexplained weight gain; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include mouth sores; numbness or loss of feeling in the hands or feet; weakness.

Proper storage of Docetaxel :

Docetaxel is usually handled and stored by a health care provider. If you are using Docetaxel at home, store Docetaxel as directed by your pharmacist or health care provider. Keep Docetaxel out of the reach of children and away from pets.

General information:

  • If you have any questions about Docetaxel , please talk with your doctor, pharmacist, or other health care provider.
  • Docetaxel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Docetaxel . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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