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|Dinoprostone |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home Dinoprostone( PGE2 ; Prostaglandin E2 ) Pronouncation: (DIE-no-PROSTE-ohn)Class: Prostaglandin, Agent for cervical ripening Trade Names: Trade Names: Trade Names: Mechanism of ActionPharmacologyStimulates gravid uterus to contract; also stimulates smooth muscle of GI tract. PharmacokineticsAbsorptionT max is 0.5 to 0.75 hr (gel). C max approximately 484 pg/mL (gel). MetabolismRapidly metabolized in the local tissue. Systemically absorbed drug is extensively metabolized in the lungs, liver, and kidney. Eliminationt ½ is 2.5 to 5 min. Metabolites excreted in the urine. Indications and UsageGelCervical ripening in pregnant women at or near term with need for labor induction. Vaginal suppositoriesTermination of pregnancy from 12 to 20 wk. ContraindicationsHypersensitivity to prostaglandins; patients in whom oxytocic drugs are contraindicated or when prolonged contractions of uterus are considered inappropriate; ruptured membranes; placenta previa; unexplained vaginal bleeding during current pregnancy; when vaginal delivery is not indicated; acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease. Dosage and AdministrationCervical RipeningAdults Intravaginal Gel 0.5 mg (contents of one syringe); may repeat dose 6 hr later if necessary (max dose 1.5 mg (3 syringes/24 hr). Intravaginal Insert 10 mg (1 insert). Releases approximately 0.3 mg/hr over 12 hr. Remove insert upon onset of active labor or 12 hr after insertion. Termination of PregnancyAdults Intravaginal 1 suppository (20 mg) high into vagina. Repeat at 3 to 5 hr intervals until abortion occurs. Do not give continuously for longer than 2 days. General Advice
Storage/StabilityStore suppository and insert in freezer. Store gel in refrigerator. Bring both to room temperature just prior to use, do not use external sources of heat (eg, hot water bath, microwave oven) to decrease warming time. Drug InteractionsOxytocic agentsMay augment effect of other oxytocic agents; avoid concomitant use. Laboratory Test InteractionsNone well documented. Adverse ReactionsCardiovascularTransient fall in BP; syncope; dizziness; arrhythmias. CNSHeadache; flushing; anxiety; tension; hot flashes; paresthesia; weakness. EENTBlurred vision; eye pain. GIAnorexia; nausea; vomiting; diarrhea. GenitourinaryUterine contractile abnormality; endometritis; uterine rupture; uterine pain; amnionitis; premature rupture of membranes; vaginal pain; warm feeling in vagina. RespiratoryBronchospasm; coughing; dyspnea; wheezing. MiscellaneousBack pain; muscular cramps; fever; chills; joint inflammation; breast tenderness; diaphoresis; rash; leg cramps; dehydration. Fetal effects: Fetal heart rate abnormalities; bradycardia; deceleration; sepsis; depression (1 min Apgar less than 7); acidosis. Precautions
PregnancyCategory C . Contraindicated if fetus in utero has reached viability stage except when cervical ripening is indicated. LactationUndetermined. Special Risk PatientsUse with caution in patients with asthma, glaucoma, or raised IOP, hypotension or hypertension, cardiovascular or renal or hepatic dysfunction, anemia, jaundice, diabetes, epilepsy, compromised uterus, infected endocervical lesions; acute vaginitis. OverdosageSymptomsUterine hypercontractility, uterine hypertonus. Patient Information
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