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Iprivask, |desirudin Desirudin

desirudin

Generic Name: desirudin (deh sih rue din)
Brand Names: Iprivask

What is desirudin?

Desirudin is an anticoagulant (blood thinner). Desirudin prevents the formation of blood clots.

Desirudin is used to prevent deep vein thrombosis (a type of blood clot), which may lead to pulmonary embolism (blood clot in the lung), in patients undergoing hip replacement surgery.

Desirudin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about desirudin?

There is a risk of bleeding in the spinal or epidural space, possibly resulting in paralysis, when desirudin is used along with spinal or epidural anesthesia or spinal puncture. This risk may be increased by the use of indwelling epidural catheters or by the concomitant use of drugs that affect blood clotting.

What should I discuss with my healthcare provider before using desirudin?

• have a very low level of platelets in your blood;

• have uncontrolled active bleeding;

• have an allergy to desirudin or other blood thinners; or

• cannot have accurate blood testing done prior to and during dosing.

Before using desirudin, tell your doctor if you

• have bacterial endocarditis;

• have high blood pressure that is not being controlled;

• need to have or have recently had surgery, a biopsy, or another invasive procedure;

• have a history of stroke or bleeding in the brain;

• have a history of bleeding in the eyes (hemorrhagic retinopathy);

• have eye problems due to diabetes (diabetic retinopathy);

• have hemophilia or another blood disorder;

• have a stomach ulcer;

• have liver disease; or
• have kidney disease.

You may not be able to use desirudin, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.

How should I use desirudin?

Desirudin will probably be administered by a healthcare professional. If you are using desirudin at home, administer the medication exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

If you are using the medication at home, your doctor or nurse will give you detailed instructions on how to inject desirudin. It should be injected into the fat of the stomach or the upper thighs. Follow your doctor"s instructions.

Sit or lie down before receiving an injection. Lift a fold of skin and insert the needle completely into the fold. The whole length of the needle should be introduced into the skin fold and the skin fold should be held throughout the injection. To lessen bruising, do not rub the area after injecting the medication. Rotate the injection sites as directed by your doctor.

It is important to use desirudin regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with desirudin to monitor progress and side effects.

What happens if I miss a dose?

Contact your doctor if you miss a dose of desirudin.

What happens if I overdose?

Symptoms of an overdose may include unusual bleeding from wounds or injection sites; nosebleeds; black, bloody, or tarry stools; blood in the urine; and easy bruising or bleeding.

What should I avoid while using desirudin?

Desirudin side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• any prolonged or unexplained bleeding;

• pain, warmth, or redness in an arm or leg, or difficulty breathing, which could indicate a blood clot; or

• ulceration at the injection site.

Other less serious side effects may be more likely to occur. Continue to use desirudin and notify your doctor if you experience

• mild pain, redness, or warmth at the injection site;

• anemia (low level of red blood cells detected by blood tests); or

• nausea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect desirudin?

There is a risk of bleeding in the spinal or epidural space, possibly resulting in paralysis, when desirudin is used along with spinal or epidural anesthesia or spinal puncture. This risk may be increased by the use of indwelling epidural catheters or by the concomitant use of drugs that affect blood clotting.

• aspirin,

• ibuprofen (Motrin, Advil, Nuprin, and others), ketoprofen (Orudis KT, Orudis, Oruvail), naproxen (Aleve, Naprosyn, Anaprox, and others), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), or any other nonsteroidal anti-inflammatory medication;

• dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), tinzaparin (Innohep);

• warfarin (Coumadin);

• aspirin and dipyridamole (Aggrenox);

• ticlopidine (Ticlid) or clopidogrel (Plavix); or

• dipyridamole (Persantine).

The drugs listed above may increase the effects of desirudin, which could become dangerous. You may not be able to take desirudin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with desirudin. Talk to your doctor and pharmacist before using any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has additional information about desirudin written for health professionals that you may read.

What does my medication look like?

Desirudin is available with a prescription under the brand name Iprivask. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.