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|Colestipol

COLESTIPOL (Oral)

Some commonly used brand names are:

In the U.S.—

• Colestid

In Canada—

• Colestid

Category

• Antidiarrheal, postoperative colonic bile acids
• Antihyperlipidemic
• Antipruritic, cholestasis

Description

Colestipol (koe-LES-ti-pole) is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels.

Colestipol works by attaching to certain substances in the intestine. Since colestipol is not absorbed into the body, these substances also pass out of the body without being absorbed.

Colestipol may also be used for other conditions as determined by your doctor.

Colestipol is available only with your doctor"s prescription, in the following dosage form:

• Oral
• Powder (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For colestipol, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to colestipol. Also tell your health care professional if you are allergic to any substances, such as foods, preservatives, or dyes.

Pregnancy—Colestipol is not absorbed into the body and is not likely to cause problems. However, it may reduce absorption of vitamins into the body. Ask your doctor whether you need to take extra vitamins.

Breast-feeding—Colestipol is not absorbed into the body and is not likely to cause problems.

Children—There is no specific information comparing use of colestipol in children with use in other age groups. However, use is not recommended in children under 2 years of age since cholesterol is needed for normal development.

Older adults—Side effects may be more likely to occur in patients over 60 years of age, who are usually more sensitive to the effects of colestipol.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking colestipol it is especially important that your health care professional knows if you are taking any of the following:

• Anticoagulants (blood thinners)—The effects of the anticoagulant may be altered

• Digitalis glycosides (heart medicine) or
• Diuretics (water pills) or
• Penicillin G, taken by mouth, or
• Propranolol, taken by mouth, or
• Tetracyclines (medicine for infection), taken by mouth, or
• Thyroid hormones or
• Vancomycin, taken by mouth—Colestipol may cause these medicines to be less effective; these medicines should be taken 4 to 5 hours apart from colestipol

Other medical problems—The presence of other medical problems may affect the use of colestipol. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or
• Constipation or
• Gallstones or
• Heart or blood vessel disease or
• Hemorrhoids or
• Stomach ulcer or other stomach problems or
• Underactive thyroid—Colestipol may make these conditions worse

• Kidney disease—There is an increased risk of developing electrolyte problems

• Liver disease—Cholesterol levels may be raised

Proper Use of This Medicine

Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor"s orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.

Also, this medicine is less effective if you are greatly overweight. It may be very important for you to go on a reducing diet. However, check with your doctor before going on any diet.

Make certain your health care professional knows if you are on a low-sodium, low-sugar, or any other special diet.

Take this medicine exactly as directed by your doctor . Try not to miss any doses and do not take more medicine than your doctor ordered.

Follow carefully the special diet your doctor gave you . This is the most important part of controlling your condition and is necessary if the medicine is to work properly.

This medicine should never be taken in its dry form, since it could cause you to choke . Instead, always mix as follows:

• Add this medicine to 3 ounces or more of water, milk, flavored drink, or your favorite juice or carbonated drink. If you use a carbonated drink, slowly mix in the powder in a large glass to prevent too much foaming. Stir until it is completely mixed (it will not dissolve) before drinking. After drinking all the liquid containing the medicine, rinse the glass with a little more liquid and drink that also, to make sure you get all the medicine.
• You may also mix this medicine with milk in hot or regular breakfast cereals, or in thin soups such as tomato or chicken noodle soup. Or you may add it to some pulpy fruits such as crushed pineapple, pears, peaches, or fruit cocktail.

Dosing—The dose of colestipol will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of colestipol. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage form (powder for oral suspension):
  • For high cholesterol:
    • Adults—15 to 30 grams a day. This is divided into two to four doses and taken before meals.
    • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. Then go back to your regular dosing schedule. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits . This will allow your doctor to see if the medicine is working properly to lower your cholesterol levels and to decide if you should continue to take it.

Do not stop taking this medicine without first checking with your doctor . When you stop taking this medicine, your blood cholesterol levels may increase again. Your doctor may want you to follow a special diet to help prevent this from happening.

Do not take any other medicine unless prescribed by your doctor since colestipol may interfere with other medicines.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if either of the following side effects occurs:

Check with your doctor as soon as possible if either of the following side effects occurs:

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Additional Information

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, colestipol is used in certain patients with the following medical conditions:

• Diarrhea caused by bile acids
• Digitalis glycoside overdose
• Excess oxalate in the urine
• Itching (pruritus) associated with partial biliary obstruction

Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.

Revised: 04/14/1994

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