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Generic Name: Benztropine Injection (BENZ-troe-peen)
Brand Name: Cogentin

Cogentin is used for:

Treating Parkinson disease in combination with other medicines. It is also used to control tremors and stiffness of the muscles due to certain antipsychotic medicines (eg, phenothiazines).

Cogentin is an anticholinergic. It works by decreasing the effects of acetylcholine, a chemical in the brain. This results in decreased tremors or muscle stiffness.

Do NOT use Cogentin if:

  • you are allergic to any ingredient in Cogentin
  • you have angle-closure glaucoma, bleeding problems, esophageal achalasia, myasthenia gravis, intestinal or urinary blockage, or ulcerative colitis

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cogentin :

Some medical conditions may interact with Cogentin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription medicine, nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an enlarged prostate, an irregular heartbeat, glaucoma or risk factors for glaucoma, tardive dyskinesia, or urinary retention

Some MEDICINES MAY INTERACT with Cogentin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Phenothiazines (eg, chlorpromazine) or tricyclic antidepressants (eg, amitriptyline) because serious, sometimes fatal side effects may occur, including paralysis of the intestines, increased body heat, or heatstroke

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cogentin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cogentin :

Use Cogentin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cogentin is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Cogentin at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Cogentin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Cogentin , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cogentin .

Important safety information:

  • Cogentin may cause blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Cogentin . Using Cogentin alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. It may take several weeks for Cogentin to work.
  • Cogentin may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise and fever can increase these effects. To prevent these effects, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Cogentin can reduce the ability to sweat and cause the body to overheat. Do NOT become overheated in hot weather or during exercise or other activities since heatstroke may occur.
  • LAB TESTS, including liver function, kidney function, lung function, blood pressure, fasting blood glucose, and blood cholesterol, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Cogentin is not recommended for use in CHILDREN younger than 3 years of age. Safety and effectiveness in this age group have not been confirmed.
  • Caution is advised when using Cogentin in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Cogentin , discuss with your doctor the benefits and risks of using Cogentin during pregnancy. It is unknown if Cogentin is excreted in breast milk. If you are or will be breast-feeding while you are using Cogentin , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Cogentin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; depression; dilated pupils; disorientation; dizziness; drowsiness; dry mouth; fast heartbeat; hallucinations; headache; heat stroke; impaired memory; increased sensitivity of eyes to light; lack of drive; lightheadedness; loss of appetite; nausea; nervousness; numbness of fingers; sleeplessness; stomach upset; trembling of hands; urinary retention; weak or stiff muscles.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; difficult or painful urination; difficulty swallowing; eye pain; fast or pounding heartbeat; increase in body temperature; mood or mental changes; uncontrolled movements; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include convulsions; dilated pupils; fast breathing; fast heartbeat; hot, dry, flushed skin; foul-smelling breath; hyperactivity; seizures.

Proper storage of Cogentin :

Cogentin is usually handled and stored by a health care provider. If you are using Cogentin at home, store Cogentin as directed by your pharmacist or health care provider. Keep Cogentin out of the reach of children and away from pets.

General information:

  • If you have any questions about Cogentin , please talk with your doctor, pharmacist, or other health care provider.
  • Cogentin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cogentin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition
Copyright © 2006 Wolters Kluwer Health, Inc.

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