Chlorpromazine

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|Chlorpromazine

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Chlorpromazine


Generic Name: Chlorpromazine Injection (klor-PRO-mah-zeen)
Brand Name: Thorazine

Chlorpromazine is used for:

Treating certain types of emotional, behavioral, or mental conditions. In addition, it may be used to control nausea, vomiting, or continuous hiccups, treat the blood disease porphyria, or to help to treat tetanus. It may also be used to treat other conditions as determined by your doctor, which may not be listed in the professional package insert.

Chlorpromazine is a phenothiazine. The exact way Chlorpromazine works is not known.

Do NOT use Chlorpromazine if:

  • you are allergic to any ingredient in Chlorpromazine
  • you have severe CNS depression (drowsiness leading to unconsciousness or coma)
  • you are also taking cisapride, dofetilide, H1 antagonists (eg, astemizole, terfenadine), 1A and 1C antiarrhythmics (eg, quinidine, flecainide), metrizamide, pimozide, quinolones (eg, sparfloxacin), or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpromazine :

Some medical conditions may interact with Chlorpromazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart, lung, liver, or kidney problems; or a history of breast cancer
  • if you have seizures, blood disease, low blood pressure, glaucoma, an enlarged prostate, or difficulty urinating
  • if you have Parkinson disease, Reye syndrome, or alcoholism, or drink more than 3 alcohol-containing drinks per day

Some MEDICINES MAY INTERACT with Chlorpromazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine) because the effectiveness of Chlorpromazine may be decreased
  • Metrizamide because side effects, such as increased risk of seizures, may occur
  • Arsenic, beta-adrenergic blockers (eg, propranolol), cisapride, dofetilide, droperidol, H1 antagonists (eg, astemizole), haloperidol, IA and IC antiarrhythmics (eg, quinidine, flecainide), macrolide antibiotics (eg, azithromycin), ketolides (eg, telithromycin), meperidine, pimozide, quinolones (eg, sparfloxacin), streptogramins (eg, quinupristin), tricyclic antidepressants (eg, amitriptyline), or ziprasidone because side effects, such as rapid or irregular heartbeat, low blood pressure, difficult or slow breathing, or drowsiness leading to coma, may occur
  • Guanethidine, levodopa, pergolide, or warfarin because the effectiveness of these medicines may be decreased
  • Beta-blockers (eg, propanolol), epinephrine, or hydantoins (eg, phenytoin), because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpromazine :

Use Chlorpromazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpromazine is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Chlorpromazine at home, carefully follow the injection procedures taught to you by your health care provider. Ask any questions that you may have about Chlorpromazine or giving injections.
  • If Chlorpromazine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Chlorpromazine may irritate skin. Avoid contact with skin or clothing. Wear rubber gloves while using Chlorpromazine .
  • Do not stop taking Chlorpromazine suddenly or without checking with your doctor.
  • Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Chlorpromazine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine .

Important safety information:

  • Chlorpromazine may cause drowsiness, dizziness, blurred vision, or fainting. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Chlorpromazine . Using Chlorpromazine alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Chlorpromazine . Chlorpromazine will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Chlorpromazine .
  • Do not become overheated in hot weather or during exercise or other activities while you are using Chlorpromazine because heat stroke may occur.
  • Chlorpromazine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Involuntary and uncontrollable movements may develop in patients taking Chlorpromazine . Occurrence is highest among the elderly, especially women. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However, it is possible to develop these symptoms after short-term treatment at low doses. Contact your doctor at once if any of the following occur: involuntary movements of tongue, face, mouth or jaw (eg, protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements), sometimes accompanied by involuntary movements of the arms and legs.
  • Neuroleptic malignant syndrome (NMS) is a potentially deadly syndrome associated with Chlorpromazine . Symptoms include increased body heat; rigid muscles; altered mental abilities, including lack of response to your surroundings; irregular or fast heartbeat; and sweating. Contact your doctor at once if any of these symptoms occur.
  • Use Chlorpromazine with caution in the ELDERLY because they may be more sensitive to its effects, especially low blood pressure and nerve-muscle reactions.
  • Chlorpromazine is not recommended for use in CHILDREN younger than 6 months of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Chlorpromazine during pregnancy. Chlorpromazine is excreted in breast milk. Do not breast-feed while using Chlorpromazine .

Possible side effects of Chlorpromazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness; drowsiness; dry mouth; light sensitivity; nasal congestion.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision; chest pain; chills; confusion; difficulty swallowing; difficulty urinating; drooling; extreme tiredness; fever; inability to move eyes; involuntary movements of the face, mouth, tongue, or jaw; jitteriness; lip smacking or puckering; mask-like face; muscle spasms of the face, neck, or back; prolonged or painful erection; puffing of cheeks; rigid muscles; seizures; shuffling walk; skin discoloration; sleeplessness; sore throat; stiff arms or legs; tremors of hands; twitching or twisting movements; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Proper storage of Chlorpromazine :

Store between 59 and 86 degrees F (15 and 30 degrees C), away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine out of the reach of children and away from pets.

General information:

  • If you have any questions about Chlorpromazine , please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpromazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Chlorpromazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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