Chloroquine
 Chloroquine Tablets

drug-information.ru

|Chloroquine Chloroquine Tablets

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Chloroquine


Generic Name: Chloroquine Phosphate
Dosage Form: Tablets

Rx Only

FOR MALARIA AND EXTRAINTESTINAL AMEBIASIS

Chloroquine Description

Chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water.

Chloroquine phosphate is an antimalarial and amebicidal drug.

Chemically, it is 7-Chloro-4[[4-(diethylamino)-1-methylbutyl]amino] quinoline phosphate (1:2). It has the following structural formula:

Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base.

Inactive Ingredients: Citric Acid, Anhydrous, Hydrogenated Vegetable Oil, Lactose Monohydrate, Magnesium Stearate, Corn Starch, Pregelatinized Starch, Starch.

Chloroquine - Clinical Pharmacology

Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents. Excretion of Chloroquine is quite slow, but is increased by acidification of the urine. Chloroquine is deposited in the tissues in considerable amounts. In animals, from 200 to 700 times the plasma concentration may be found in the liver, spleen, kidney, and lung; leukocytes also concentrate the drug. The brain and spinal cord, in contrast, contain only 10 to 30 times the amount present in plasma.

Chloroquine undergoes appreciable degradation in the body. The main metabolite is desethylChloroquine, which accounts for one fourth of the total material appearing in the urine; bisdesethylChloroquine, a carboxylic acid derivative, and other metabolic products as yet uncharacterized are found in small amounts. Slightly more than half of the urinary drug products can be accounted for as unchanged Chloroquine.

Microbiology

Mechanism of Action

Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of Chloroquine is not completely certain.

Activity in vitro and in vivo

Chloroquine is active against the erythrocytic forms of Plasmodium vivax, Plasmodium malariae, and susceptible strains of Plasmodium falciparum (but not the gametocytes of P. falciparum). It is not effective against exoerythrocytic forms of the parasite.

In vitro studies with trophozoites of Entamoeba histolytica have demonstrated that Chloroquine also possesses amebicidal activity comparable to that of emetine.

Drug Resistance

Resistance of Plasmodium falciparum to Chloroquine is widespread and cases of Plasmodium vivax resistance have been reported.

Indications and Usage for Chloroquine

Chloroquine phosphate tablets are indicated for the suppressive treatment and for acute attacks of malaria due to P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated for the treatment of extraintestinal amebiasis.

Chloroquine does not prevent relapses in patients with vivax or malariae malaria because it is not effective against exoerythrocytic forms of the parasite, nor will it prevent vivax or malariae infection when administered as a prophylactic. It is highly effective as a suppressive agent in patients with vivax or malariae malaria, in terminating acute attacks, and significantly lengthening the interval between treatment and relapse. In patients with falciparum malaria it abolishes the acute attack and effects complete cure of the infection, unless due to a resistant strain of P. falciparum.

Contraindications

Use of this drug is contraindicated in the presence of retinal or visual field changes either attributable to 4-aminoquinoline compounds or to any other etiology, and in patients with known hypersensitivity to 4-aminoquinoline compounds. However, in the treatment of acute attacks of malaria caused by susceptible strains of plasmodia, the physician may elect to use this drug after carefully weighing the possible benefits and risks to the patient.

Warnings

It has been found that certain strains of P. falciparum have become resistant to 4-aminoquinoline compounds (including Chloroquine and hydroxyChloroquine).

Chloroquine resistance is widespread and, at present, is particularly prominent in various parts of the world including sub-Saharan Africa, Southeast Asia, the Indian subcontinent, and over large portions of South America, including the Amazon basin1.

Before using Chloroquine for prophylaxis, it should be ascertained whether Chloroquine is appropriate for use in the region to be visited by the traveler. Chloroquine should not be used for treatment of P. falciparum infections acquired in areas of Chloroquine resistance or malaria occurring in patients where Chloroquine prophylaxis has failed.

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy.

Irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapy. Retinopathy has been reported to be dose related.

When prolonged therapy with any antimalarial compound is contemplated, initial (base line) and periodic ophthalmologic examinations (including visual acuity, expert slitlamp, funduscopic, and visual field tests) should be performed.

If there is any indication (past or present) or abnormality in the visual acuity, visual field, or retinal macular areas (such as pigmentary changes, loss of foveal reflex), or any visual symptoms (such as light flashes and streaks) which are not fully explainable by difficulties of accommodation or corneal opacities, the drug should be discontinued immediately and the patient closely observed for possible progression. Retinal changes (and visual disturbances) may progress even after cessation of therapy.

All patients on long-term therapy with this preparation should be questioned and examined periodically, including testing knee and ankle reflexes, to detect any evidence of muscular weakness. If weakness occurs, discontinue the drug.

A number of fatalities have been reported following the accidental ingestion of Chloroquine, sometimes in relatively small doses (0.75 g or 1 g Chloroquine phosphate in one 3-year-old child). Patients should be strongly warned to keep this drug out of the reach of children because they are especially sensitive to the 4-aminoquinoline compounds.

Use of Chloroquine in patients with psoriasis may precipitate a severe attack of psoriasis. When used in patients with porphyria the condition may be exacerbated. The drug should not be used in these conditions unless in the judgment of the physician the benefit to the patient outweighs the potential risks.

Usage in Pregnancy

Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women. Usage of Chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus.

Precautions

Hematological Effects/Laboratory Tests

Complete blood cell counts should be made periodically if patients are given prolonged therapy. If any severe blood disorder appears which is not attributable to the disease under treatment, discontinuance of the drug should be considered.

The drug should be administered with caution to patients having G-6-PD (glucose-6 phosphate dehydrogenase) deficiency.

Auditory Effects

In patients with preexisting auditory damage, Chloroquine should be administered with caution. In case of any defects in hearing, Chloroquine should be immediately discontinued, and the patient closely observed (see ADVERSE REACTIONS).

Hepatic Effects

Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

Central Nervous System Effects

Patients with history of epilepsy should be advised about the risk of Chloroquine provoking seizures.

Drug Interactions

Antacids and kaolin

Antacids and kaolin can reduce the absorption of Chloroquine; an interval of at least 4 hours between intake of these agents and Chloroquine should be observed.

Cimetidine

Cimetidine can inhibit the metabolism of Chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided.

Ampicillin

In a study of healthy volunteers, Chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of this agent and Chloroquine should be observed.

Cyclosporin

After introduction of Chloroquine (oral form), a sudden increase in serum cyclosporin level has been reported. Therefore, close monitoring of serum cyclosporin level is recommended and, if necessary, Chloroquine should be discontinued.

Pregnancy

See WARNINGS, Usage in Pregnancy.

Nursing Mothers

Because of the potential for serious adverse reactions in nursing infants from Chloroquine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the potential clinical benefit of the drug to the mother.

Pediatric Use

See WARNINGS and DOSAGE AND ADMINISTRATION.

Geriatric Use

Clinical studies of Chloroquine did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. However, this drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function.

Adverse Reactions

Special Senses: Ocular: Irreversible retinal damage in patients receiving long-term or high-dose 4-aminoquinoline therapy; visual disturbances (blurring of vision and difficulty of focusing or accommodation); nyctalopia; scotomatous vision with field defects of paracentral, pericentral ring types, and typically temporal scotomas, e.g., difficulty in reading with words tending to disappear, seeing half an object, misty vision, and fog before the eyes.

Auditory: Nerve type deafness; tinnitus, reduced hearing in patients with preexisting auditory damage.

Musculoskeletal system: Skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, which may be associated with mild sensory changes, depression of tendon reflexes and abnormal nerve conduction, have been noted.

Gastrointestinal system: Anorexia, nausea, vomiting, diarrhea, abdominal cramps.

Skin and appendages: Pleomorphic skin eruptions, skin and mucosal pigmentary changes; lichen planus-like eruptions, pruritus, photosensitivity and hair loss and bleaching of hair pigment.

Hematologic system: Rarely, aplastic anemia, reversible agranulocytosis, thrombocytopenia and neutropenia.

Central Nervous system: Convulsive seizures. Mild and transient headache. Neuropsychiatric changes including psychosis, delirium, personality changes and depression.

Cardiovascular system: Rarely, hypotension, electrocardiographic change (particularly, inversion or depression of the T-wave with widening of the QRS complex), and cardiomyopathy.

Overdosage

Symptoms

Chloroquine is very rapidly and completely absorbed after ingestion. Toxic doses of Chloroquine can be fatal. As little as 1 g may be fatal in children. Toxic symptoms can occur within minutes. These consist of headache, drowsiness, visual disturbances, nausea and vomiting, cardiovascular collapse, shock and convulsions followed by sudden and early respiratory and cardiac arrest. The electrocardiogram may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, and progressive bradycardia leading to ventricular fibrillation and/or arrest.

Treatment

Treatment is symptomatic and must be prompt with immediate evacuation of the stomach by emesis (at home, before transportation to the hospital) or gastric lavage until the stomach is completely emptied. If finely powdered, activated charcoal is introduced by stomach tube, after lavage, and within 30 minutes after ingestion of the antimalarial, it may inhibit further intestinal absorption of the drug. To be effective, the dose of activated charcoal should be at least five times the estimated dose of Chloroquine ingested.

Convulsions, if present, should be controlled before attempting gastric lavage. If due to cerebral stimulation, cautious administration of an ultra short-acting barbiturate may be tried but, if due to anoxia, it should be corrected by oxygen administration and artificial respiration. Monitor ECG. In shock with hypotension, a potent vasopressor should be administered. Replace fluids and electrolytes as needed. Cardiac compressing or pacing may be indicated to sustain the circulation. Because of the importance of supporting respiration, tracheal intubation or tracheostomy, followed by gastric lavage, may also be necessary. Peritoneal dialysis and exchange transfusions have also been suggested to reduce the level of the drug in the blood.

A patient who survives the acute phase and is asymptomatic should be closely observed for at least six hours. Fluids may be forced, and sufficient ammonium chloride (8 g daily in divided doses for adults) may be administered for a few days to acidify the urine to help promote urinary excretion in cases of both overdosage or sensitivity.

Chloroquine Dosage and Administration

The dosage of Chloroquine is often expressed in terms of equivalent Chloroquine base. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight.

Malaria: Suppression-Adult Dose: 500 mg (= 300 mg base) on exactly the same day of each week.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of body weight, but should not exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy should begin two weeks prior to exposure. However, failing this in adults, an initial double (loading) dose of 1 g (= 600 mg base), or in children 10 mg base/kg may be taken in two divided doses, six hours apart. The suppressive therapy should be continued for eight weeks after leaving the endemic area.

For Treatment of Acute Attack.

Adults: An initial dose of 1 g (= 600 mg base) followed by an additional 500 mg (= 300 mg base) after six to eight hours and a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents a total dose of 2.5 g Chloroquine phosphate or 1.5 g base in three days.

The dosage for adults of low body weight and for infants and children should be determined as follows:

First dose: 10 mg base per kg (but not exceeding a single dose of 600 mg base)

Second dose: (6 hours after first dose) 5 mg base per kg (but not exceeding a single dose of 300 mg base)

Third dose: (24 hours after first dose) 5 mg base per kg

Fourth dose: (36 hours after first dose) 5 mg base per kg

For radical cure of vivax and malariae malaria concomitant therapy with an 8-amino-quinoline compound is necessary.

Extraintestinal Amebiasis: Adults, 1 g (600 mg base) daily for two days, followed by 500 mg (300 mg base) daily for at least two to three weeks. Treatment is usually combined with an effective intestinal amebicide.

Geriatric Use

See PRECAUTIONS, Geriatric Use.

How is Chloroquine Supplied

Chloroquine Phosphate Tablets USP 500 mg: Each round, white to off-white compressed tablet contains 500 mg of Chloroquine phosphate, equivalent to 300 mg of Chloroquine base. Each tablet debossed with 7010

Bottles of 25   . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . NDC 0115-7010-09
Bottles of 100 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . NDC 0115-7010-01
Bottles of 500 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . NDC 0115-7010-02

Dispense in tight, light-resistant container, as defined in the USP/NF.

Store at 25°C (77°F) excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature]

Mfg. by: IMPAX Laboratories, Inc.
              Hayward, CA 94544 USA

Dist. by: Global Pharmaceuticals
              Division of IMPAX Laboratories, Inc.
              Philadelphia, PA 19124 USA

REFERENCES

  1. Malaria Deaths Following Inappropriate Malaria Chemoprophylaxis - United States, 2001. MMWR Weekly, 2001; 50(28): 597-599
  2. Ullberg S, Lindquist N G, Sjostrand S E: Accumulation of chorioretinotoxic drugs in the foetal eye. Nature 1970; 227: 1257.

07/03
350-01


Chloroquine Phosphate (Chloroquine Phosphate)
PRODUCT INFO
Product Code 0115-7010 Dosage Form TABLET
Route Of Administration ORAL DEA Schedule
INGREDIENTS
Name (Active Moiety) Type Strength
Chloroquine Phosphate (Chloroquine) Active 500 MILLIGRAM  In 1 TABLET
citric acid Inactive  
anhydrous Inactive  
hydrogenated vegetable oil Inactive  
lactose monohydrate Inactive  
magnesium stearate Inactive  
corn starch Inactive  
pregelatinized starch Inactive  
starch Inactive  
IMPRINT INFORMATION
Characteristic Appearance Characteristic Appearance
Color WHITE (white to off-white) Score 1
Shape ROUND (ROUND) Symbol false
Imprint Code 7010 Coating false
Size 14mm
PACKAGING
# NDC Package Description Multilevel Packaging
1 0115-7010-09 25 TABLET In 1 BOTTLE None
2 0115-7010-01 100 TABLET In 1 BOTTLE None
3 0115-7010-02 500 TABLET In 1 BOTTLE None

Revised: 10/2006





Where can I get more information about Chloroquine Chloroquine Tablets ? We recommend to use www.Drugs.com

Typical mistypes for Chloroquine Chloroquine Tablets
xhloroquine chloroquine tablets, vhloroquine chloroquine tablets, fhloroquine chloroquine tablets, dhloroquine chloroquine tablets, cgloroquine chloroquine tablets, cbloroquine chloroquine tablets, cnloroquine chloroquine tablets, cjloroquine chloroquine tablets, culoroquine chloroquine tablets, cyloroquine chloroquine tablets, chkoroquine chloroquine tablets, chporoquine chloroquine tablets, chooroquine chloroquine tablets, chliroquine chloroquine tablets, chlkroquine chloroquine tablets, chllroquine chloroquine tablets, chlproquine chloroquine tablets, chl0roquine chloroquine tablets, chl9roquine chloroquine tablets, chloeoquine chloroquine tablets, chlodoquine chloroquine tablets, chlofoquine chloroquine tablets, chlotoquine chloroquine tablets, chlo5oquine chloroquine tablets, chlo4oquine chloroquine tablets, chloriquine chloroquine tablets, chlorkquine chloroquine tablets, chlorlquine chloroquine tablets, chlorpquine chloroquine tablets, chlor0quine chloroquine tablets, chlor9quine chloroquine tablets, chloro1uine chloroquine tablets, chloro2uine chloroquine tablets, chlorowuine chloroquine tablets, chloroauine chloroquine tablets, chloroqyine chloroquine tablets, chloroqhine chloroquine tablets, chloroqjine chloroquine tablets, chloroqiine chloroquine tablets, chloroq8ine chloroquine tablets, chloroq7ine chloroquine tablets, chloroquune chloroquine tablets, chloroqujne chloroquine tablets, chloroqukne chloroquine tablets, chloroquone chloroquine tablets, chloroqu9ne chloroquine tablets, chloroqu8ne chloroquine tablets, chloroquibe chloroquine tablets, chloroquime chloroquine tablets, chloroquije chloroquine tablets, chloroquihe chloroquine tablets, chloroquinw chloroquine tablets, chloroquins chloroquine tablets, chloroquind chloroquine tablets, chloroquinr chloroquine tablets, chloroquin4 chloroquine tablets, chloroquin3 chloroquine tablets, chloroquine xhloroquine tablets, chloroquine vhloroquine tablets, chloroquine fhloroquine tablets, chloroquine dhloroquine tablets, chloroquine cgloroquine tablets, chloroquine cbloroquine tablets, chloroquine cnloroquine tablets, chloroquine cjloroquine tablets, chloroquine culoroquine tablets, chloroquine cyloroquine tablets, chloroquine chkoroquine tablets, chloroquine chporoquine tablets, chloroquine chooroquine tablets, chloroquine chliroquine tablets, chloroquine chlkroquine tablets, chloroquine chllroquine tablets, chloroquine chlproquine tablets, chloroquine chl0roquine tablets, chloroquine chl9roquine tablets, chloroquine chloeoquine tablets, chloroquine chlodoquine tablets, chloroquine chlofoquine tablets, chloroquine chlotoquine tablets, chloroquine chlo5oquine tablets, chloroquine chlo4oquine tablets, chloroquine chloriquine tablets, chloroquine chlorkquine tablets, chloroquine chlorlquine tablets, chloroquine chlorpquine tablets, chloroquine chlor0quine tablets, chloroquine chlor9quine tablets, chloroquine chloro1uine tablets, chloroquine chloro2uine tablets, chloroquine chlorowuine tablets, chloroquine chloroauine tablets, chloroquine chloroqyine tablets, chloroquine chloroqhine tablets, chloroquine chloroqjine tablets, chloroquine chloroqiine tablets, chloroquine chloroq8ine tablets, chloroquine chloroq7ine tablets, chloroquine chloroquune tablets, chloroquine chloroqujne tablets, chloroquine chloroqukne tablets, chloroquine chloroquone tablets, chloroquine chloroqu9ne tablets, chloroquine chloroqu8ne tablets, chloroquine chloroquibe tablets, chloroquine chloroquime tablets, chloroquine chloroquije tablets, chloroquine chloroquihe tablets, chloroquine chloroquinw tablets, chloroquine chloroquins tablets, chloroquine chloroquind tablets, chloroquine chloroquinr tablets, chloroquine chloroquin4 tablets, chloroquine chloroquin3 tablets, chloroquine chloroquine rablets, chloroquine chloroquine fablets, chloroquine chloroquine gablets, chloroquine chloroquine yablets, chloroquine chloroquine 6ablets, chloroquine chloroquine 5ablets, chloroquine chloroquine tzblets, chloroquine chloroquine tsblets, chloroquine chloroquine twblets, chloroquine chloroquine tqblets, chloroquine chloroquine tavlets, chloroquine chloroquine tanlets, chloroquine chloroquine tahlets, chloroquine chloroquine taglets, chloroquine chloroquine tabkets, chloroquine chloroquine tabpets, chloroquine chloroquine taboets, chloroquine chloroquine tablwts, chloroquine chloroquine tablsts, chloroquine chloroquine tabldts, chloroquine chloroquine tablrts, chloroquine chloroquine tabl4ts, chloroquine chloroquine tabl3ts, chloroquine chloroquine tablers, chloroquine chloroquine tablefs, chloroquine chloroquine tablegs, chloroquine chloroquine tableys, chloroquine chloroquine table6s, chloroquine chloroquine table5s, chloroquine chloroquine tableta, chloroquine chloroquine tabletz, chloroquine chloroquine tabletx, chloroquine chloroquine tabletd, chloroquine chloroquine tablete, chloroquine chloroquine tabletw, hloroquine chloroquine tablets, cloroquine chloroquine tablets, choroquine chloroquine tablets, chlroquine chloroquine tablets, chlooquine chloroquine tablets, chlorquine chloroquine tablets, chlorouine chloroquine tablets, chloroqine chloroquine tablets, chloroqune chloroquine tablets, chloroquie chloroquine tablets, chloroquin chloroquine tablets, chloroquine chloroquine tablets, chloroquine chloroquine tablets, chloroquine hloroquine tablets, chloroquine cloroquine tablets, chloroquine choroquine tablets, chloroquine chlroquine tablets, chloroquine chlooquine tablets, chloroquine chlorquine tablets, chloroquine chlorouine tablets, chloroquine chloroqine tablets, chloroquine chloroqune tablets, chloroquine chloroquie tablets, chloroquine chloroquin tablets, chloroquine chloroquinetablets, chloroquine chloroquine ablets, chloroquine chloroquine tblets, chloroquine chloroquine talets, chloroquine chloroquine tabets, chloroquine chloroquine tablts, chloroquine chloroquine tables, chloroquine chloroquine tablet, hcloroquine chloroquine tablets, clhoroquine chloroquine tablets, cholroquine chloroquine tablets, chlrooquine chloroquine tablets, chloorquine chloroquine tablets, chlorqouine chloroquine tablets, chlorouqine chloroquine tablets, chloroqiune chloroquine tablets, chloroqunie chloroquine tablets, chloroquien chloroquine tablets, chloroquin e chloroquine tablets, chloroquine chloroquine tablets, chloroquine c hloroquine tablets, chloroquine hcloroquine tablets, chloroquine clhoroquine tablets, chloroquine cholroquine tablets, chloroquine chlrooquine tablets, chloroquine chloorquine tablets, chloroquine chlorqouine tablets, chloroquine chlorouqine tablets, chloroquine chloroqiune tablets, chloroquine chloroqunie tablets, chloroquine chloroquien tablets, chloroquine chloroquin etablets, chloroquine chloroquinet ablets, chloroquine chloroquine atblets, chloroquine chloroquine tbalets, chloroquine chloroquine talbets, chloroquine chloroquine tabelts, chloroquine chloroquine tabltes, chloroquine chloroquine tablest, cchloroquine chloroquine tablets, chhloroquine chloroquine tablets, chlloroquine chloroquine tablets, chlooroquine chloroquine tablets, chlorroquine chloroquine tablets, chlorooquine chloroquine tablets, chloroqquine chloroquine tablets, chloroquuine chloroquine tablets, chloroquiine chloroquine tablets, chloroquinne chloroquine tablets, chloroquinee chloroquine tablets, chloroquine chloroquine tablets, chloroquine chloroquine tablets, chloroquine cchloroquine tablets, chloroquine chhloroquine tablets, chloroquine chlloroquine tablets, chloroquine chlooroquine tablets, chloroquine chlorroquine tablets, chloroquine chlorooquine tablets, chloroquine chloroqquine tablets, chloroquine chloroquuine tablets, chloroquine chloroquiine tablets, chloroquine chloroquinne tablets, chloroquine chloroquinee tablets, chloroquine chloroquine tablets, chloroquine chloroquine ttablets, chloroquine chloroquine taablets, chloroquine chloroquine tabblets, chloroquine chloroquine tabllets, chloroquine chloroquine tableets, chloroquine chloroquine tabletts, chloroquine chloroquine tabletss, etc.



© Copyright by drug-information.ru 2001-2019. All rights reserved