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|Chloromycetin Otic Solution |
| Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home ChloromycetinGeneric Name: chloramphenicol Dosage Form: Otic solution WARNING Bone marrow hypoplasia including aplastic anemia and death has been reported following local application of chloramphenicol. Chloramphenicol should not be used when less potentially dangerous agents would be expected to provide effective treatment. DescriptionEach milliliter of Chloromycetin Otic contains 5 mg (0.5%) chloramphenicol in propylene glycol. Sterile. The chemical names for chloramphenicol are:
Chloramphenicol has the following empirical and structural formulas:
Clinical PharmacologyChloramphenicol is a broad-spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes. Development of resistance to chloramphenicol can be regarded as minimal for staphylococci and many other species of bacteria. Indications and UsageChloromycetin (chloramphenicol) Otic is indicated for the treatment of surface infections of the external auditory canal caused by susceptible strains of various gram-positive and gram-negative organisms including: Staphylococcus aureus, Escherichia coli, Hemophilus influenzae, Pseudomonas aeruginosa, Aerobacter aerogenes, Klebsiella pneumoniae and Proteus species. Deeper infections should be treated with appropriate systemic antibiotics. ContraindicationsThis product is contraindicated in persons sensitive to any of its components. Perforated tympanic membrane is considered a contraindication to the use of any medication in the external ear canal. WarningsSEE BOXED WARNING. Discontinue promptly if sensitization or irritation occurs. PrecautionsThe prolonged use of antibiotics may occasionally result in overgrowth of nonsusceptible organisms, including fungi. If new infections appear during medication, the drug should be discontinued and appropriate measures should be taken. In all serious infections, the topical use of chloramphenicol should be supplemented by appropriate systemic medication. The possibility of the occurrence of ototoxicity must be considered if this product is allowed to enter the middle ear. Adverse ReactionsSigns of local irritation with subjective symptoms of itching or burning, angioneurotic edema, urticaria, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol and are causes for discontinuing the medication. Similar sensitivity reactions to other materials in topical preparations may also occur. Blood dyscrasias have been reported in association with the use of chloramphenicol (see WARNINGS). Dosage and AdministrationInstill 2 or 3 drops into the affected ear three times daily. How SuppliedNDC 61570-331-31 Chloromycetin (chloramphenicol) Otic is supplied in 15 mL vials with droppers. Store below 30°C (86°F). Chloromycetin, brand of chloramphenicol, Reg US Pat Off. Rx only. Rev. 12/98 Manufactured by: Parkedale Pharmaceuticals, Inc., Rochester, MI 48307 Distributed by:Monarch Pharmaceuticals, Inc., Bristol, TN 37620
Revised: 04/2007 Where can I get more information about Chloromycetin Otic Solution ? 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