cevimeline Cevimeline HCl

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Evoxac, |cevimeline Cevimeline HCl
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cevimeline

Generic Name: cevimeline (se vi ME leen)
Brand Names: Evoxac

What is cevimeline?

Cevimeline increases the secretions of the saliva and sweat glands in the body.

Cevimeline is used to treat dry mouth in people with Sjogren"s Syndrome.

Cevimeline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about cevimeline?

Do not take this medication if you are allergic to cevimeline, or if you have untreated or uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis.

Before taking cevimeline, tell your doctor if you have heart disease, heart rhythm disorder, angina (chest pain), or a history of heart attack, high blood pressure (hypertension), asthma or other breathing disorder, or a history of kidney or gall stones.

Cevimeline can cause side effects that may impair your vision, especially at night. Be careful if you drive or do anything that requires you to be able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline may cause excessive sweating and you may get dehydrated more easily while taking this medication. Follow your doctor"s instructions about the type and amount of liquids you should drink.

Who should not take cevimeline?

Do not take this medication if you are allergic to cevimeline, or if you have:

  • untreated or uncontrolled asthma;

  • glaucoma; or

  • an eye condition called iritis or uveitis.

Before taking cevimeline, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease, heart rhythm disorder, angina (chest pain), or a history of heart attack;

  • high blood pressure (hypertension);

  • asthma, chronic bronchitis, or chronic obstructive pulmonary disease (COPD); or

  • a history of kidney stones or gallstones.

If you have any of these conditions, you may not be able to use cevimeline, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether cevimilene passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take cevimeline?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medication with a full glass of water.

Cevimeline is usually taken three times a day. Follow your doctor"s instructions.

Store cevimeline at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a cevimeline overdose may include headache, blurred vision, watery eyes, confusion, sweating, tremors or shaking, nausea, vomiting, diarrhea, stomach pain, trouble breathing, and fast, slow, or uneven heart rate.

What should I avoid while taking cevimeline?

Cevimeline can cause side effects that may impair your vision, especially at night. Be careful if you drive or do anything that requires you to be able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline may cause excessive sweating and you may get dehydrated more easily while taking this medication. Follow your doctor"s instructions about the type and amount of liquids you should drink.

Cevimeline side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking cevimeline and call your doctor at once if you have any of these serious side effects:

  • shortness of breath, wheezing, or tightness in your chest;

  • chest pain, uneven heart rate;

  • attacks of severe stomach pain on the right side, extending up to your shoulder (sometimes worse after meals);

  • nausea and vomiting, bloating, fever, chills, and jaundice (yellowing of the skin or eyes);

  • swelling in your hands or feet;

  • eye pain or drainage;

  • fever, ear ache, flu symptoms; or

  • white patches or sores inside your mouth or on your lips.

Keep taking cevimeline and talk to your doctor if you have any of these less serious side effects:

  • blurred vision, dry eyes;

  • excessive sweating or salivating, drooling;

  • runny or stuffy nose;

  • nausea, diarrhea, constipation, loss of appetite;

  • dry mouth;

  • muscle pain;

  • vaginal itching or discharge;

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect cevimeline?

Before taking cevimeline, tell your doctor if you are using any of the following drugs:

  • amiodarone (Cordarone, Pacerone);

  • cimetidine (Tagamet);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • metronidazole (Flagyl, Protostat);

  • antibiotics such as azithromycin (Zithromax), ciprofloxacin (Cipro), clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Ery-Tab, Erythrocin), itraconazole (Sporanox), or ketoconazole (Nizoral);

  • antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft);

  • asthma medicines such as albuterol (Proventil, Ventolin, others), bitolterol (Tornalate), epinephrine (Asthmahaler, Bronkaid, Primatene Mist Inhaler), isoetharine (Bronkometer, Bronkosol), metaproterenol (Alupent, Metaprel), pirbuterol (Maxair), salmeterol (Serevent), or terbutaline (Brethaire, Brethine);

  • heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac) or verapamil (Calan, Covera, Isoptin, Verelan), acebutolol (Sectral), atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others; or

  • HIV /AIDS medicine such as amprenavir (Agenerase), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), or saquinavir (Invirase, Fortovase).

If you are using any of these drugs, you may not be able to use cevimeline, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect cevimeline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has information about cevimeline written for health professionals that you may read.

What does my medication look like?

Cevimeline is available with a prescription under the brand name Evoxac. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Evoxac 30 mg-white, hard gelatin capsules

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.04. Revision Date: 04/30/2007 12:19:20 PM.



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