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|Cefotaxime and Dextrose Cefotaxime Sodium |
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The drug chamber is filled with sterile Cefotaxime Sodium USP, a semisynthetic, broad-spectrum, cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate 72 (Z)-(o-methyloxime), acetate (ester). The CAS Registry Number is 64485-93-4. Cefotaxime Sodium has the following structural formula: The empirical formula of Cefotaxime Sodium is C16H16N5NaO7S2, representing a molecular weight of 477.45. Cefotaxime Sodium contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. The diluent chamber contains Dextrose Injection. The concentration of Hydrous Dextrose in Water for Injection USP has been adjusted to render the reconstituted drug product iso-osmotic. Dextrose Injection is sterile, nonpyrogenic, and contains no bacteriostatic or antimicrobial agents. Hydrous Dextrose USP has the following structural (molecular) formula: The molecular weight of Hydrous Dextrose USP is 198.17. Cefotaxime Sodium is supplied as a dry powder form equivalent to either 1 g or 2 g of cefotaxime. Dextrose hydrous USP has been added to the diluent to adjust osmolality (approximately 1.95 g and 1.2 g to 1 g and 2 g dosages, respectively). After removing the peelable foil strip, activating the seals, and thoroughly mixing, the reconstituted drug product is intended for single intravenous use. When reconstituted, the approximate osmolality for the reconstituted solution for Cefotaxime for Injection USP and Dextrose Injection is 290 mOsmol/kg. The DUPLEX dual chamber container is made from a specially formulated material. The product (diluent and drug) contact layer is a mixture of thermoplastic rubber and a polypropylene ethylene copolymer that contains no plasticizers. The safety of the container system is supported by USP biological evaluation procedures. Cefotaxime and Dextrose - Clinical PharmacologyThere was a dose-dependent increase in serum levels after the IV administration of 500 mg, 1 g, and 2 g of cefotaxime (38.9, 101.7, and 214.4 µg/mL respectively) without alteration in the elimination half-life. There is no evidence of accumulation following repetitive IV infusion of 1 g doses every 6 hours for 14 days as there are no alterations of serum or renal clearance. About 60% of the administered dose was recovered from urine during the first 6 hours following the start of the infusion. Approximately 20–36% of an intravenously administered dose of 14C-cefotaxime is excreted by the kidney as unchanged cefotaxime and 15–25% as the desacetyl derivative, the major metabolite. The desacetyl metabolite has been shown to contribute to the bactericidal activity. Two other urinary metabolites (M2 and M3) account for about 20–25%. They lack bactericidal activity. A single 50 mg/kg dose of cefotaxime was administered as an intravenous infusion over a 10- to 15- minute period to 29 newborn infants grouped according to birth weight and age. The mean half-life of cefotaxime in infants with lower birth weights (≤1500 grams), regardless of age, was longer (4.6 hours) than the mean half-life (3.4 hours) in infants whose birth weight was greater than 1500 grams. Mean serum clearance was also smaller in the lower birth weight infants. Although the differences in mean half-life values are statistically significant for weight, they are not clinically important. Therefore, dosage should be based solely on age. (See DOSAGE AND ADMINISTRATION section.) Additionally, no disulfiram-like reactions were reported in a study conducted in 22 healthy volunteers administered cefotaxime and ethanol. MicrobiologyThe bactericidal activity of cefotaxime sodium results from inhibition of cell wall synthesis. Cefotaxime sodium has in vitro activity against a wide range of gram-positive and gram-negative organisms. Cefotaxime sodium has a high degree of stability in the presence of β-lactamases, both penicillinases and cephalosporinases, of gram-negative and gram-positive bacteria. Cefotaxime sodium has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. Aerobes, Gram-positive: Enterococcus spp. Aerobes, Gram-negative: Acinetobacter spp. NOTE: Many strains of the above organisms that are multiply resistant to other antibiotics, e.g. penicillins, cephalosporins, and aminoglycosides, are susceptible to cefotaxime sodium. Cefotaxime sodium is active against some strains of Pseudomonas aeruginosa. Anaerobes: Bacteroides spp., including some strains of Bacteroides fragilis Cefotaxime sodium also demonstrates in vitro activity against the following microorganisms but the clinical significance is unknown. Cefotaxime sodium exhibits in vitro minimal inhibitory concentrations (MIC"s) of 8 µg/mL or less against most (≥90%) strains of the following microorganisms; however, the safety and effectiveness of cefotaxime sodium in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled clinical trials: Aerobes, Gram-negative: Providencia spp. Cefotaxime sodium is highly stable in vitro to four of the five major classes of β-lactamases described by Richmond et al.1, including type IIIa (TEM) which is produced by many gram-negative bacteria. The drug is also stable to β-lactamase (penicillinase) produced by staphylococci. In addition, cefotaxime sodium shows high affinity for penicillin-binding proteins in the cell wall, including PBP: Ib and III. Cefotaxime sodium and aminoglycosides have been shown to be synergistic in vitro against some strains of Pseudomonas aeruginosa but the clinical significance is unknown.
Dilution Techniques Quantitative methods that are used to determine minimum inhibitory concentrations (MIC"s) provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure uses a standardized dilution method2 (broth or agar) or equivalent with cefotaxime sodium powder. The MIC values obtained should be interpreted according to the following criteria:
A report of "Susceptible" indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of "Intermediate" indicates that the result should be considered equivocal and if the microorganism is not fully susceptible to alternative clinically feasible drugs the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of "Resistant" indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable, other therapy should be selected. Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the laboratory procedure.3 Standard cefotaxime sodium powder should provide the following MIC values:
Diffusion Techniques Quantitative methods that require measurements of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure4 requires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 30 µg cefotaxime sodium to test the susceptibility of microorganisms to cefotaxime sodium. Reports from the laboratory providing results of the standard single-disk susceptibility test using a 30 µg cefotaxime sodium disk should be interpreted according to the following criteria:
Interpretation should be as stated above for results using dilution techniques. Interpretation involves correlation of the diameter obtained in the disk test with the MIC for cefotaxime sodium. As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. For the diffusion technique, the 30 µg cefotaxime sodium disk should provide the following zone diameters in these laboratory test quality control strains:
Anaerobic Techniques For anaerobic bacteria, the susceptibility to cefotaxime sodium as MICs can be determined by standardized test methods.5 The MIC values obtained should be interpreted according to the following criteria:
Interpretation is identical to that stated above for results using dilution techniques. As with other susceptibility techniques, the use of laboratory control microorganisms is required to control the technical aspects of the laboratory standardized procedures. Standardized cefotaxime sodium powder should provide the following MIC values:
Indications and Usage for Cefotaxime and DextroseTreatmentCefotaxime for Injection USP and Dextrose Injection is indicated for the treatment of patients with serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below.
Although many strains of enterococci (e.g., E. faecalis) and Pseudomonas species are resistant to cefotaxime sodium in vitro, cefotaxime has been used successfully in treating patients with infections caused by susceptible organisms. Specimens for bacteriologic culture should be obtained prior to therapy in order to isolate and identify causative organisms and to determine their susceptibilities to cefotaxime. Therapy may be instituted before results of susceptibility studies are known; however, once these results become available, the antibiotic treatment should be adjusted accordingly. In certain cases of confirmed or suspected gram-positive or gram-negative sepsis or in patients with other serious infections in which the causative organism has not been identified, cefotaxime may be used concomitantly with an aminoglycoside. The dosage recommended in the labeling of both antibiotics may be given and depends on the severity of the infection and the patient"s condition. Renal function should be carefully monitored, especially if higher dosages of the aminoglycosides are to be administered or if therapy is prolonged, because of the potential nephrotoxicity and ototoxicity of aminoglycoside antibiotics. It is possible that nephrotoxicity may be potentiated if cefotaxime is used concomitantly with an aminoglycoside.
PreventionThe administration of cefotaxime preoperatively reduces the incidence of certain infections in patients undergoing surgical procedures (e.g., abdominal or vaginal hysterectomy, gastrointestinal and genitourinary tract surgery) that may be classified as contaminated or potentially contaminated. In patients undergoing cesarean section, intraoperative (after clamping the umbilical cord) and postoperative use of cefotaxime may also reduce the incidence of certain postoperative infections. See DOSAGE AND ADMINISTRATION section. Effective use for elective surgery depends on the time of administration. To achieve effective tissue levels, cefotaxime should be given 1/2 or 1 1/2 hours before surgery. See DOSAGE AND ADMINISTRATION section. For patients undergoing gastrointestinal surgery, preoperative bowel preparation by mechanical cleansing as well as with a non-absorbable antibiotic (e.g., neomycin) is recommended. If there are signs of infection, specimens for culture should be obtained for identification of the causative organism so that appropriate therapy may be instituted. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefotaxime for Injection USP and Dextrose Injection and other antibacterial drugs, Cefotaxime for Injection USP and Dextrose Injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. ContraindicationsCefotaxime for Injection USP and Dextrose Injection is contraindicated in patients who have shown hypersensitivity to cefotaxime sodium or the cephalosporin group of antibiotics. Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products. WarningsBEFORE THERAPY WITH CEFOTAXIME FOR INJECTION USP AND DEXTROSE INJECTION IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFOTAXIME SODIUM, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. THIS PRODUCT SHOULD BE GIVEN WITH CAUTION TO PATIENTS WITH TYPE I HYPERSENSITIVITY REACTIONS TO PENICILLIN. ANTIBIOTICS SHOULD BE ADMINISTERED WITH CAUTION TO ANY PATIENT WHO HAS DEMONSTRATED SOME FORM OF ALLERGY, PARTICULARLY TO DRUGS. IF AN ALLERGIC REACTION TO CEFOTAXIME FOR INJECTION USP AND DEXTROSE INJECTION OCCURS, DISCONTINUE TREATMENT WITH THE DRUG. SERIOUS HYPERSENSITIVITY REACTIONS MAY REQUIRE EPINEPHRINE AND OTHER EMERGENCY MEASURES. During post-marketing surveillance, a potentially life-threatening arrhythmia was reported in each of six patients who received a rapid (less than 60 seconds) bolus injection of cefotaxime through a central venous catheter. Therefore, cefotaxime should only be administered as instructed in the DOSAGE AND ADMINISTRATION section. Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Cefotaxime for Injection USP and Dextrose Injection, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated. PrecautionsGeneralPrescribing Cefotaxime for Injection USP and Dextrose Injection in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. Cefotaxime for Injection USP and Dextrose Injection should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Because high and prolonged serum antibiotic concentrations can occur from usual doses in patients with transient or persistent reduction of urinary output because of renal insufficiency, the total daily dosage should be reduced when cefotaxime is administered to such patients. Continued dosage should be determined by degree of renal impairment, severity of infection, and susceptibility of the causative organism. It is suggested that, based upon the data available from published studies the dose of cefotaxime sodium be halved in patients with estimated creatinine clearances of less than 20 mL/min/1.73 m2. When only serum creatinine is available, the following formula6 (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function.
As with other antibiotics, prolonged use of cefotaxime may result in overgrowth of nonsusceptible organisms. Repeated evaluation of the patient"s condition is essential. If superinfection occurs during therapy, appropriate measures should be taken. As with other beta-lactam antibiotics, granulocytopenia and, more rarely, agranulocytosis may develop during treatment with cefotaxime, particularly if given over long periods. For courses of treatment lasting longer than 10 days, blood counts should therefore be monitored. Cefotaxime, like other parenteral anti-infective drugs, may be locally irritating to tissues. In most cases, perivascular extravasation of cefotaxime responds to changing of the infusion site. In rare instances, extensive perivascular extravasation of cefotaxime may result in tissue damage and require surgical treatment. To minimize the potential for tissue inflammation, infusion sites should be monitored regularly and changed when appropriate. As with other dextrose-containing solutions, Cefotaxime for Injection USP and Dextrose Injection should be prescribed with caution in patients with overt or known subclinical diabetes mellitus or carbohydrate intolerance for any reason. If administration is controlled by a pumping device, care must be taken to discontinue pumping action before the container runs dry or air embolism may result. Use only if solution is clear and container and seals are intact. Information for PatientsDiarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Patients should be counseled that antibacterial drugs including Cefotaxime for Injection USP and Dextrose Injection should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Cefotaxime for Injection USP and Dextrose Injection is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Cefotaxime for Injection USP and Dextrose Injection or other antibacterial drugs in the future. Drug InteractionsIncreased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics. Drug/Laboratory Test InteractionsCephalosporins, including cefotaxime sodium, are known to occasionally induce a positive direct Coombs test. Carcinogenesis, MutagenesisLifetime studies in animals to evaluate carcinogenic potential have not been conducted. Cefotaxime was not mutagenic in the mouse micronucleus test or in the Ames" test. Cefotaxime did not impair fertility to rats when administered subcutaneously at doses up to 250 mg/kg/day (0.2 times the maximum recommended human dose based on mg/m2) or in mice when administered intravenously at doses up to 2000 mg/kg/day (0.7 times the recommended human dose based on mg/m2). PregnancyTeratogenic EffectsPregnancy Category BReproduction studies have been performed in pregnant mice given cefotaxime intravenously at doses up to 1200 mg/kg/day (0.4 times the recommended human dose based on mg/m2) or in pregnant rats when administered intravenously at doses up to 1200 mg/kg/day (0.8 times the recommended human dose based on mg/m2). No evidence of embryotoxicity or teratogenicity was seen in these studies. There are no well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nonteratogenic EffectsUse of the drug in women of child-bearing potential requires that the anticipated benefit be weighed against the possible risks. In perinatal and postnatal studies with rats, the pups in the group given 1200 mg/kg/day of cefotaxime were significantly lighter in weight at birth and remained smaller than pups in the control group during the 21 days of nursing. Nursing MothersCefotaxime is excreted in human milk in low concentrations. Caution should be exercised when cefotaxime is administered to a nursing woman. Pediatric UseSee PRECAUTIONS above regarding perivascular extravasation. Cefotaxime for Injection USP and Dextrose Injection in the DUPLEX® Container is designed to deliver a 1 g or 2 g dose of cefotaxime. To prevent unintentional overdose, this product should not be used in pediatric patients who require less than the full adult dose of cefotaxime. Geriatric UseOf the 1409 subjects in clinical studies of cefotaxime, 632 (45%) were 65 and over, while 258 (18%) were 75 and over. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see PRECAUTIONS, General). Adverse ReactionsCefotaxime is generally well tolerated. The most common adverse reactions have been local reactions following IV injection. Other adverse reactions have been encountered infrequently. The most frequent adverse reactions (greater than 1%) are:
Less frequent adverse reactions (less than 1%) are:
Cephalosporin Class LabelingIn addition to the adverse reactions listed above which have been observed in patients treated with cefotaxime sodium, the following adverse reactions and altered laboratory tests have been reported for cephalosporin class antibiotics: allergic reactions, hepatic dysfunction including cholestasis, aplastic anemia, hemorrhage, and false-positive test for urinary glucose. Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. See DOSAGE AND ADMINISTRATION and OVERDOSAGE. If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated. OverdosageThe acute toxicity of cefotaxime was evaluated in neonatal and adult mice and rats. Significant mortality was seen at parenteral doses in excess of 6000 mg/kg/day in all groups. Common toxic signs in animals that died were a decrease in spontaneous activity, tonic and clonic convulsions, dyspnea, hypothermia, and cyanosis. Cefotaxime sodium overdosage has occurred in patients. Most cases have shown no overt toxicity. The most frequent reactions were elevations of BUN and creatinine. Patients who receive an acute overdosage should be carefully observed and given supportive treatment. Cefotaxime and Dextrose Dosage and AdministrationThis product is intended for intravenous administration only. AdultsGeriatric UseThis drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function (see PRECAUTIONS, General and PRECAUTIONS, Geriatric Use). Dosage and route of administration should be determined by susceptibility of the causative organisms, severity of the infection, and the condition of the patient (see table for dosage guideline). Cefotaxime for Injection USP and Dextrose Injection is intended for IV administration after reconstitution. The maximum daily dosage should not exceed 12 grams.
To prevent postoperative infection in contaminated or potentially contaminated surgery, the recommended dose is a single 1 gram IV administered 30 to 90 minutes prior to start of surgery. Cesarean Section PatientsThe first dose of 1 gram is administered intravenously as soon as the umbilical cord is clamped. The second and third doses should be given as 1 gram intravenously at 6 and 12 hours after the first dose. Pediatric PatientsFor body weights less than 50 kg, the recommended daily dose is 50 to 180 mg/kg body weight divided into four to six equal doses. The higher dosages should be used for more severe or serious infections, including meningitis. For body weights 50 kg or more, the usual adult dosage should be used; the maximum daily dosage should not exceed 12 grams. Cefotaxime for Injection USP and Dextrose Injection in the DUPLEX® Container is designed to deliver 1 g or 2 g dose of cefotaxime. To prevent unintentional overdose, this product should not be used in pediatric patients who require less than the full adult dose of cefotaxime. Impaired Renal Functionsee PRECAUTIONS section. NOTE: As with antibiotic therapy in general, administration of cefotaxime should be continued for a minimum of 48 to 72 hours after the patient defervesces or after evidence of bacterial eradication has been obtained; a minimum of 10 days of treatment is recommended for infections caused by Group A beta-hemolytic streptococci in order to guard against the risk of rheumatic fever or glomerulonephritis; frequent bacteriologic and clinical appraisal is necessary during therapy of chronic urinary tract infection and may be required for several months after therapy has been completed; persistent infections may require treatment of several weeks and doses smaller than those indicated above should not be used. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. DUPLEX® Drug Delivery System Directions for UseRemoval from Multi-Pack Tray
Patient Labeling and Drug Powder/Diluent Inspection
Reconstitution (Activation)
Note: Following reconstitution (activation), product must be used within 12 hours if stored at room temperature or within 5 days if stored under refrigeration. Administration
Precautions
How is Cefotaxime and Dextrose SuppliedCefotaxime for Injection USP and Dextrose Injection in the DUPLEX Drug Delivery System is a flexible dual chamber container supplied in two concentrations. After reconstitution, the concentrations are equivalent to 1 g and 2 g cefotaxime. The diluent chamber contains approximately 50 mL of Dextrose Injection. Dextrose Injection has been adjusted to 3.9% and 2.4% for the 1 g and 2 g doses, respectively, such that the reconstituted solution is iso-osmotic. Cefotaxime for Injection USP and Dextrose Injection is supplied sterile and nonpyrogenic in the DUPLEX Drug Delivery System Containers packaged 12 units per tray, 2 trays per case.
Store the unactivated unit at 20–25°C (68–77°F). Excursions permitted to 15–30°C (59–86°F). Rx only Rev: January 2007 REFERENCES
DUPLEX® is a registered trademark of B. Braun Medical Inc. Made in USA B. Braun Medical Inc. ©2007 B. Braun Medical Inc. Y36-002-588
Revised: 03/2007 Where can I get more information about Cefotaxime and Dextrose Cefotaxime Sodium ? 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cextrose cefotaxime sodium, cefotaxime and fextrose cefotaxime sodium, cefotaxime and rextrose cefotaxime sodium, cefotaxime and eextrose cefotaxime sodium, cefotaxime and dwxtrose cefotaxime sodium, cefotaxime and dsxtrose cefotaxime sodium, cefotaxime and ddxtrose cefotaxime sodium, cefotaxime and drxtrose cefotaxime sodium, cefotaxime and d4xtrose cefotaxime sodium, cefotaxime and d3xtrose cefotaxime sodium, cefotaxime and deztrose cefotaxime sodium, cefotaxime and dectrose cefotaxime sodium, cefotaxime and dedtrose cefotaxime sodium, cefotaxime and destrose cefotaxime sodium, cefotaxime and dexrrose cefotaxime sodium, cefotaxime and dexfrose cefotaxime sodium, cefotaxime and dexgrose cefotaxime sodium, cefotaxime and dexyrose cefotaxime sodium, cefotaxime and dex6rose cefotaxime sodium, cefotaxime and dex5rose cefotaxime sodium, cefotaxime and dexteose cefotaxime sodium, cefotaxime and dextdose cefotaxime sodium, cefotaxime and dextfose cefotaxime sodium, cefotaxime and dexttose cefotaxime sodium, cefotaxime and dext5ose cefotaxime sodium, cefotaxime and dext4ose cefotaxime sodium, cefotaxime and dextrise cefotaxime sodium, cefotaxime and dextrkse cefotaxime sodium, cefotaxime and dextrlse cefotaxime sodium, cefotaxime and dextrpse cefotaxime sodium, cefotaxime and dextr0se cefotaxime sodium, cefotaxime and dextr9se cefotaxime sodium, cefotaxime and dextroae cefotaxime sodium, cefotaxime and dextroze cefotaxime sodium, cefotaxime and dextroxe cefotaxime sodium, cefotaxime and dextrode cefotaxime sodium, cefotaxime and dextroee cefotaxime sodium, cefotaxime and dextrowe cefotaxime sodium, cefotaxime and dextrosw cefotaxime sodium, cefotaxime and dextross cefotaxime sodium, cefotaxime and dextrosd cefotaxime sodium, cefotaxime and dextrosr cefotaxime sodium, cefotaxime and dextros4 cefotaxime sodium, cefotaxime and dextros3 cefotaxime sodium, cefotaxime and dextrose xefotaxime sodium, cefotaxime and dextrose vefotaxime sodium, cefotaxime and dextrose fefotaxime sodium, cefotaxime and dextrose defotaxime sodium, cefotaxime and dextrose cwfotaxime sodium, cefotaxime and dextrose csfotaxime sodium, cefotaxime and dextrose cdfotaxime sodium, cefotaxime and dextrose crfotaxime sodium, cefotaxime and dextrose c4fotaxime sodium, cefotaxime and dextrose c3fotaxime sodium, cefotaxime and dextrose cedotaxime sodium, cefotaxime and dextrose cecotaxime sodium, cefotaxime and dextrose cevotaxime sodium, cefotaxime and dextrose cegotaxime sodium, cefotaxime and dextrose cetotaxime sodium, cefotaxime and dextrose cerotaxime sodium, cefotaxime and dextrose cefitaxime sodium, cefotaxime and dextrose cefktaxime sodium, cefotaxime and dextrose cefltaxime sodium, cefotaxime and dextrose cefptaxime sodium, cefotaxime and dextrose cef0taxime sodium, cefotaxime and dextrose cef9taxime sodium, cefotaxime and dextrose ceforaxime sodium, cefotaxime and dextrose cefofaxime sodium, cefotaxime and dextrose cefogaxime sodium, cefotaxime and dextrose cefoyaxime sodium, cefotaxime and dextrose cefo6axime sodium, cefotaxime and dextrose cefo5axime sodium, cefotaxime and dextrose cefotzxime sodium, cefotaxime and dextrose cefotsxime sodium, cefotaxime and dextrose cefotwxime sodium, cefotaxime and dextrose cefotqxime sodium, cefotaxime and dextrose cefotazime sodium, cefotaxime and dextrose cefotacime sodium, cefotaxime and dextrose cefotadime sodium, cefotaxime and dextrose cefotasime sodium, cefotaxime and dextrose cefotaxume sodium, cefotaxime and dextrose cefotaxjme sodium, cefotaxime and dextrose cefotaxkme sodium, cefotaxime and dextrose cefotaxome sodium, cefotaxime and dextrose cefotax9me sodium, cefotaxime and dextrose cefotax8me sodium, cefotaxime and dextrose cefotaxine sodium, cefotaxime and dextrose cefotaxike sodium, cefotaxime and dextrose cefotaxije sodium, cefotaxime and dextrose cefotaximw sodium, cefotaxime and dextrose cefotaxims sodium, cefotaxime and dextrose cefotaximd sodium, cefotaxime and dextrose cefotaximr sodium, cefotaxime and dextrose cefotaxim4 sodium, cefotaxime and dextrose cefotaxim3 sodium, cefotaxime and dextrose cefotaxime aodium, cefotaxime and dextrose cefotaxime zodium, cefotaxime and dextrose cefotaxime xodium, cefotaxime and dextrose cefotaxime dodium, cefotaxime and dextrose cefotaxime eodium, cefotaxime and dextrose cefotaxime wodium, cefotaxime and dextrose cefotaxime sidium, cefotaxime and dextrose cefotaxime skdium, cefotaxime and dextrose cefotaxime sldium, cefotaxime and dextrose cefotaxime spdium, cefotaxime and dextrose cefotaxime s0dium, cefotaxime and dextrose cefotaxime s9dium, cefotaxime and dextrose cefotaxime sosium, cefotaxime and dextrose cefotaxime soxium, cefotaxime and dextrose cefotaxime socium, cefotaxime and dextrose cefotaxime sofium, cefotaxime and dextrose cefotaxime sorium, cefotaxime and dextrose cefotaxime soeium, cefotaxime and dextrose cefotaxime soduum, cefotaxime and dextrose cefotaxime sodjum, cefotaxime and dextrose cefotaxime sodkum, cefotaxime and dextrose cefotaxime sodoum, cefotaxime and dextrose cefotaxime sod9um, cefotaxime and dextrose cefotaxime sod8um, cefotaxime and dextrose cefotaxime sodiym, cefotaxime and dextrose cefotaxime sodihm, cefotaxime and dextrose cefotaxime sodijm, cefotaxime and dextrose cefotaxime sodiim, cefotaxime and dextrose cefotaxime sodi8m, cefotaxime and dextrose cefotaxime sodi7m, cefotaxime and dextrose cefotaxime sodiun, cefotaxime and dextrose cefotaxime sodiuk, cefotaxime and dextrose cefotaxime sodiuj, efotaxime and dextrose cefotaxime sodium, cfotaxime and dextrose cefotaxime sodium, ceotaxime and dextrose cefotaxime sodium, ceftaxime and dextrose cefotaxime sodium, cefoaxime and dextrose cefotaxime sodium, cefotxime and dextrose cefotaxime sodium, cefotaime and dextrose cefotaxime sodium, cefotaxme and dextrose cefotaxime sodium, cefotaxie and dextrose cefotaxime sodium, cefotaxim and dextrose cefotaxime sodium, cefotaximeand dextrose cefotaxime sodium, cefotaxime nd dextrose cefotaxime sodium, cefotaxime ad dextrose cefotaxime sodium, cefotaxime an dextrose cefotaxime sodium, cefotaxime anddextrose cefotaxime sodium, cefotaxime and extrose cefotaxime sodium, cefotaxime and dxtrose cefotaxime sodium, cefotaxime and detrose cefotaxime sodium, cefotaxime and dexrose cefotaxime sodium, cefotaxime and dextose cefotaxime sodium, cefotaxime and dextrse cefotaxime sodium, cefotaxime and dextroe cefotaxime sodium, cefotaxime and dextros cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose efotaxime sodium, cefotaxime and dextrose cfotaxime sodium, cefotaxime and dextrose ceotaxime sodium, cefotaxime and dextrose ceftaxime sodium, cefotaxime and dextrose cefoaxime sodium, cefotaxime and dextrose cefotxime sodium, cefotaxime and dextrose cefotaime sodium, cefotaxime and dextrose cefotaxme sodium, cefotaxime and dextrose cefotaxie sodium, cefotaxime and dextrose cefotaxim sodium, cefotaxime and dextrose cefotaximesodium, cefotaxime and dextrose cefotaxime odium, cefotaxime and dextrose cefotaxime sdium, cefotaxime and dextrose cefotaxime soium, cefotaxime and dextrose cefotaxime sodum, cefotaxime and dextrose cefotaxime sodim, cefotaxime and dextrose cefotaxime sodiu, ecfotaxime and dextrose cefotaxime sodium, cfeotaxime and dextrose cefotaxime sodium, ceoftaxime and dextrose cefotaxime sodium, ceftoaxime and dextrose cefotaxime sodium, cefoatxime and dextrose cefotaxime sodium, cefotxaime and dextrose cefotaxime sodium, cefotaixme and dextrose cefotaxime sodium, cefotaxmie and dextrose cefotaxime sodium, cefotaxiem and dextrose cefotaxime sodium, cefotaxim eand dextrose cefotaxime sodium, cefotaximea nd dextrose cefotaxime sodium, cefotaxime nad dextrose cefotaxime sodium, cefotaxime adn dextrose cefotaxime sodium, cefotaxime an ddextrose cefotaxime sodium, cefotaxime andd extrose cefotaxime sodium, cefotaxime and edxtrose cefotaxime sodium, cefotaxime and dxetrose cefotaxime sodium, cefotaxime and detxrose cefotaxime sodium, cefotaxime and dexrtose cefotaxime sodium, cefotaxime and dextorse cefotaxime sodium, cefotaxime and dextrsoe cefotaxime sodium, cefotaxime and dextroes cefotaxime sodium, cefotaxime and dextros e cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose c efotaxime sodium, cefotaxime and dextrose ecfotaxime sodium, cefotaxime and dextrose cfeotaxime sodium, cefotaxime and dextrose ceoftaxime sodium, cefotaxime and dextrose ceftoaxime sodium, cefotaxime and dextrose cefoatxime sodium, cefotaxime and dextrose cefotxaime sodium, cefotaxime and dextrose cefotaixme sodium, cefotaxime and dextrose cefotaxmie sodium, cefotaxime and dextrose cefotaxiem sodium, cefotaxime and dextrose cefotaxim esodium, cefotaxime and dextrose cefotaximes odium, cefotaxime and dextrose cefotaxime osdium, cefotaxime and dextrose cefotaxime sdoium, cefotaxime and dextrose cefotaxime soidum, cefotaxime and dextrose cefotaxime soduim, cefotaxime and dextrose cefotaxime sodimu, ccefotaxime and dextrose cefotaxime sodium, ceefotaxime and dextrose cefotaxime sodium, ceffotaxime and dextrose cefotaxime sodium, cefootaxime and dextrose cefotaxime sodium, cefottaxime and dextrose cefotaxime sodium, cefotaaxime and dextrose cefotaxime sodium, cefotaxxime and dextrose cefotaxime sodium, cefotaxiime and dextrose cefotaxime sodium, cefotaximme and dextrose cefotaxime sodium, cefotaximee and dextrose cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime aand dextrose cefotaxime sodium, cefotaxime annd dextrose cefotaxime sodium, cefotaxime andd dextrose cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and ddextrose cefotaxime sodium, cefotaxime and deextrose cefotaxime sodium, cefotaxime and dexxtrose cefotaxime sodium, cefotaxime and dexttrose cefotaxime sodium, cefotaxime and dextrrose cefotaxime sodium, cefotaxime and dextroose cefotaxime sodium, cefotaxime and dextrosse cefotaxime sodium, cefotaxime and dextrosee cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose ccefotaxime sodium, cefotaxime and dextrose ceefotaxime sodium, cefotaxime and dextrose ceffotaxime sodium, cefotaxime and dextrose cefootaxime sodium, cefotaxime and dextrose cefottaxime sodium, cefotaxime and dextrose cefotaaxime sodium, cefotaxime and dextrose cefotaxxime sodium, cefotaxime and dextrose cefotaxiime sodium, cefotaxime and dextrose cefotaximme sodium, cefotaxime and dextrose cefotaximee sodium, cefotaxime and dextrose cefotaxime sodium, cefotaxime and dextrose cefotaxime ssodium, cefotaxime and dextrose cefotaxime soodium, cefotaxime and dextrose cefotaxime soddium, cefotaxime and dextrose cefotaxime sodiium, cefotaxime and dextrose cefotaxime sodiuum, cefotaxime and dextrose cefotaxime sodiumm, etc.
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