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Some commonly used brand names are:
In the U.S.—
Doxazosin (dox-AY-zoe-sin) belongs to the general class of medicines called antihypertensives. It is used to treat high blood pressure (hypertension).
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Doxazosin works by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure.
Doxazosin is also used to treat benign (noncancerous) enlargement of the prostate (benign prostatic hyperplasia [BPH]). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.
Doxazosin helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine and/or decrease the symptoms. However, doxazosin will not shrink the prostate. The prostate may continue to get larger. This may cause the symptoms to become worse over time. Therefore, even though doxazosin may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future.
Doxazosin is available only with your doctor"s prescription, in the following dosage form:
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For doxazosin, the following should be considered:
Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to doxazosin, prazosin, or terazosin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy—Doxazosin has not been studied in pregnant women. However, studies in rabbits have shown that doxazosin given at very high doses may cause death of the fetus. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
Breast-feeding—It is not known whether doxazosin passes into breast milk. However, doxazosin passes into the milk of lactating rats. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.
Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of doxazosin in children with use in other age groups.
Older adults—Dizziness, lightheadedness, or fainting may be especially likely to occur in elderly patients with high blood pressure, because these patients are usually more sensitive than younger adults to the effects of doxazosin.
Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other medical problems—The presence of other medical problems may affect the use of doxazosin. Make sure you tell your doctor if you have any other medical problems, especially:
Proper Use of This Medicine
For the regular tablet—To help you remember to take your medicine, try to get into the habit of taking it at the same time each day.
For the extended-release tablet—
For patients taking this medicine for high blood pressure :
For patients taking this medicine for benign enlargement of the prostate :
Dosing—The dose of doxazosin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of doxazosin. If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets that you take depends on the strength of the medicine.
Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss several doses, call your doctor to see at what dose you should start again.
Storage—To store this medicine:
Precautions While Using This Medicine
It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly. This is especially important for elderly patients, who may be more sensitive to the effects of this medicine.
For patients taking this medicine for high blood pressure :
Dizziness, lightheadedness, or sudden fainting may occur after you take this medicine, especially when you get up from a lying or sitting position. These effects are more likely to occur when you take the first dose of this medicine. Taking the first dose at bedtime may prevent problems. However, be especially careful if you need to get up during the night . These effects may also occur with any doses you take after the first dose. Getting up slowly may help lessen this problem. If you feel dizzy, lie down so that you do not faint . Then sit for a few moments before standing to prevent the dizziness from returning.
The dizziness, lightheadedness, or sudden fainting is more likely to occur if you drink alcohol, stand for a long time, exercise, or if the weather is hot. While you are taking this medicine, be careful to limit the amount of alcohol you drink. Also, use extra care during exercise or hot weather or if you must stand for a long time .
Doxazosin may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, drowsy, or are not alert . After you have taken several doses of this medicine, these effects should lessen.
The possibility of priapism, a painful or prolonged erection of the penis, is a rare side effect that can occur when taking doxazosin and must have immediate medical attention.
Side Effects of This Medicine
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Dizziness or lightheadedness
Blurred vision; confusion; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; fainting (sudden); fast and pounding heartbeat; irregular heartbeat; shortness of breath; sweating; swelling of feet or lower legs
RarePainful or prolonged erection of the penis (called priapism), although extremely rare, must have immediate medical attention. If painful or prolonged erection occurs, call your doctor or go to an emergency room as soon as possible
Incidence not knownAbdominal or stomach pain; area rash; black, tarry stools; bleeding gums; blood in urine or stools; chest pain or discomfort; chills; clay-colored stools; cough; dark urine; diarrhea; difficulty breathing; difficult, burning, or painful urination; fever; general tiredness and weakness; headache, sudden and severe; inability to speak; itching; lab results that show problems with liver; light-colored stools; loss of appetite; noisy breathing; pain or discomfort in arms, jaw, back or neck; pinpoint red or purple spots on skin; rash; seizures; slow or irregular heartbeat; slurred speech; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; temporary blindness; tightness in chest; unpleasant breath odor; unusual bleeding or bruising; upper right abdominal pain; vomiting; vomiting of blood; weakness in arm and/or leg on one side of the body, sudden and severe; wheezing; yellow eyes and skin
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
Headache; lack or loss of strength; unusual tiredness or weakness
Acid or sour stomach; back pain; belching; bladder pain; cloudy urine; difficulty in moving; frequent urge to urinate; heartburn; indigestion; joint pain; lower back or side pain; muscle aching, cramping, or weakness; muscle pains or stiffness; nausea; nervousness, restlessness, unusual irritability; runny nose; sleepiness or drowsiness; sneezing; sore throat; stomach discomfort, upset or pain; swollen joints
Incidence not known
Anxiety; burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling; change in frequency or urination; dry mouth; feeling of warmth; frequent urination; general feeling of discomfort or illness; hair loss; hives or welts; hyperventilation; increased urge to urinate during the night; increased volume of pale dilute urine; loss of appetite; painful urination; redness of skin; redness of the face, neck, arms and occasionally upper chest; shaking; swelling of the breasts or breast soreness in both females and males; thinning of hair; trouble in holding or releasing urine; trouble sleeping; waking to urinate at night; weight loss
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.
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