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|Carbidopa, Levodopa

Carbidopa, Levodopa

Generic name: Carbidopa, Levodopa
Brand names: Sinemet CR

Why is Carbidopa, Levodopa prescribed?

Carbidopa, Levodopa is a controlled-release tablet that may be given to help relieve the muscle stiffness, tremor, and weakness caused by Parkinson"s disease. It may also be given to relieve Parkinson-like symptoms caused by encephalitis (brain fever), carbon monoxide poisoning, or manganese poisoning.

Carbidopa, Levodopa contains two drugs, carbidopa and levodopa. The drug that actually produces the anti-Parkinson"s effect is levodopa. Carbidopa prevents vitamin B₆ from destroying levodopa, thus allowing levodopa to work more efficiently.

Parkinson"s drugs such as Carbidopa, Levodopa relieve the symptoms of the disease, but are not a permanent cure.

Most important fact about Carbidopa, Levodopa

There is also a regular, non-controlled-release form of Carbidopa, Levodopa, which is called Sinemet. Over a period of hours, Carbidopa, Levodopa, the controlled-release form, gives a smoother release of the drug than regular Sinemet. If you have been taking regular Sinemet, be aware that you may need a somewhat higher dosage of Carbidopa, Levodopa to get the same degree of relief. Your first morning dose of Carbidopa, Levodopa may take as much as an hour longer to start working than your first morning dose of regular Sinemet.

How should you take Carbidopa, Levodopa?

Take Carbidopa, Levodopa after meals, rather than before or between meals. Swallow the tablets whole without chewing or crushing them.

Carbidopa, Levodopa releases its ingredients slowly over a period of 4 to 6 hours. It is important to follow a careful schedule, taking your doses at the same time every day.

You should not change the prescribed dosage or add another product for Parkinson"s disease without first consulting your doctor.

Carbidopa, Levodopa works best when there is a constant amount in the blood. Try not to miss any doses, and take them at evenly spaced intervals day and night.

--If you miss a dose...

If you forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

--Storage instructions...

Store at room temperature in a tightly closed container.

What side effects may occur?

Side effects from Carbidopa, Levodopa cannot be anticipated. If any develop or change in intensity, inform your doctor immediately.

Only your doctor can determine if it is safe for you to continue taking Carbidopa, Levodopa.

• More common side effects may include:Confusion, hallucinations, nausea, uncontrollable twitching or jerking

Why should Carbidopa, Levodopa not be prescribed?

Do not take Carbidopa, Levodopa if you are sensitive to or have ever had an allergic reaction to its ingredients.

Carbidopa, Levodopa should not be prescribed if you have a suspicious, undiagnosed mole or a history of melanoma.

Special warnings about Carbidopa, Levodopa

Make sure your doctor knows if you have any of the following:

Bronchial asthma
Cardiovascular or lung disease (severe)
Endocrine (glandular) disorder
History of heart attack or heartbeat irregularity
History of active peptic ulcer
Kidney disorder
Liver disorder
Wide-angle glaucoma (pressure in the eye)

Your doctor will monitor your liver, blood, kidney and heart functions during extended therapy with Carbidopa, Levodopa.

If you have been taking levodopa alone, you should stop taking levodopa for at least 12 hours before starting to take Carbidopa, Levodopa.

The carbidopa contained in Carbidopa, Levodopa cannot eliminate side effects caused by levodopa. Since carbidopa helps levodopa reach your brain, Carbidopa, Levodopa may, in fact, produce some levodopa side effects--particularly twitching, jerking, or writhing--sooner and at a lower dosage than levodopa alone or even regular Sinemet. If such involuntary movements develop while you are taking Carbidopa, Levodopa, you may need a dosage reduction.

Like levodopa, Carbidopa, Levodopa may cause depression. Make sure your doctor knows if you have mental or emotional problems.

Muscle rigidity, high temperature, rapid heartbeat or breathing, sweating, blood pressure changes, and mental changes may occur when Carbidopa, Levodopa is reduced suddenly or discontinued. If you stop taking Carbidopa, Levodopa abruptly, your doctor should monitor your condition carefully.

You may see a red, brown, or black coloration in your saliva, urine, or sweat. This is not harmful, but may stain your clothes. Too much stomach acid can interfere with absorption of the medication.

Possible food and drug interactions when taking Carbidopa, Levodopa

If Carbidopa, Levodopa is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Carbidopa, Levodopa with the following:

Antacids such as Di-Gel, Maalox, and Mylanta
Antiseizure drugs such as Dilantin
Antispasmodic drugs such as Artane and Cogentin
Antihypertensives such as Aldomet and Clonidine
High-protein foods
Isoniazid (Nydrazid)
Major tranquilizers such as Haldol, Mellaril, Risperdal, and Thorazine
MAO inhibitors such as the antidepressants Nardil and Parnate and the Parkinson"s drug Eldepryl
Methionine drugs such as Pedameth
Metoclopramide (Reglan)
Papaverine (Pavabid)
Pyridoxine (Vitamin B₆)
Tranquilizers such as Dalmane, Valium, and Xanax
Tricyclic antidepressants such as Elavil and Tofranil

If you have been taking an MAO inhibitor such as Nardil or Parnate, you must discontinue it at least 2 weeks before starting to take Carbidopa, Levodopa.

A high-protein diet may impair the effectiveness of Sinement CR. Iron supplements can also reduce its effect.

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, inform your doctor immediately. Carbidopa, Levodopa should be used during pregnancy only if the benefit outweighs the potential risk to the unborn child. It is not known whether Carbidopa, Levodopa appears in breast milk. If Carbidopa, Levodopa is essential to your health, your doctor may advise you to stop nursing your baby until your treatment with Carbidopa, Levodopa is finished.

Recommended dosage

Your doctor will tailor your individual dosage carefully, depending on your response to previous therapy and symptoms.

ADULTS

For patients with mild to moderate symptoms, the initial recommended dose is 1 tablet of Carbidopa, Levodopa taken 2 times a day.

Starting doses should be spaced out every 4 to 8 hours and then adjusted to each patient"s individual response.

The usual long-term dose is 2 to 8 tablets per day, taken in divided doses every 4 to 8 hours during the waking day.

Higher doses (12 or more tablets per day) and shorter intervals (less than 4 hours) have been used, but are not usually recommended.

When doses of Carbidopa, Levodopa are given at intervals of less than 4 hours, and/or if the divided doses are not equal, it is recommended that the smaller doses be given at the end of the day.

An interval of at least 3 days between dosage adjustments is recommended.

Dosage adjustment of Carbidopa, Levodopa may be necessary if your doctor prescribes additional medications.

CHILDREN

Use of Carbidopa, Levodopa in children under 18 is not recommended.

Overdosage

Too much Carbidopa, Levodopa may cause muscle twitches, inability to open the eyes, or other symptoms of levodopa overdosage. Like other medications, Carbidopa, Levodopa taken in excess can have serious consequences. If you suspect symptoms of a Carbidopa, Levodopa overdose, seek medical attention immediately.