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|Brinzolamide |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home BrinzolamidePronouncation: (brin-ZOE-lah-mide)Class: Carbonic anhydrase inhibitor Trade Names: Mechanism of ActionPharmacologyInhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, resulting in a reduction in IOP. PharmacokineticsAbsorptionFollowing ocular administration, absorbed into the systemic circulation. DistributionDistributes extensively into RBCs. Protein binding is about 60%. MetabolismMetabolite is N-desethylbrinzolamide. EliminationEliminated predominantly unchanged in the urine. Metabolites also found in the urine. Indications and UsageTreatment of elevated IOP in patients with ocular hypertension or open-angle glaucoma. ContraindicationsStandard considerations. Dosage and AdministrationAdultsOphthalmic 1 gtt in affected eye(s) 3 times daily. General Advice
Storage/StabilityStore below 86°F. Keep dropper bottle tightly closed. Drug InteractionsNone well documented. Laboratory Test InteractionsNone well documented. Adverse ReactionsCNSHeadache (1% to 5%). DermatologicDermatitis (1% to 5%). EENTBlurred vision (5% to 10%); blepharitis, dry eye, foreign body sensation, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, rhinitis (1% to 5%). GIBitter, sour, or unusual taste (5% to 10%). Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. Renal FunctionUse not recommended. Hepatic FunctionUse with caution. SulfonamidesBrinzolamide is a sulfonamide and adverse reactions attributable to sulfonamides may occur (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, aplastic anemia, death). OverdosageSymptomsElectrolyte imbalance, acidotic state, possible nervous system effects. Patient Information
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