Bortezomib

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|Bortezomib

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Bortezomib


Generic Name: Bortezomib (bor-TEZ-oh-mib)
Brand Name: Velcade

Bortezomib is used for:

Treating certain types of cancer (eg, multiple myeloma, mantle cell lymphoma). It may also be used for other conditions as determined by your doctor.

Bortezomib is an antineoplastic (cancer chemotherapy) medicine. It works by blocking certain proteins within the cancer cell, causing the cell to die. This helps to slow the growth and spread of the cancer.

Do NOT use Bortezomib if:

  • you are allergic to any ingredient in Bortezomib , including boron or mannitol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bortezomib :

Some medical conditions may interact with Bortezomib . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, a low white blood cell count, low blood platelets, peripheral neuropathy (numbness, pain, or burning sensations in the hands or feet), heart problems (eg, congestive heart failure), low blood pressure, diabetes, or lung problems
  • if you are dehydrated or you have a history of fainting

Some MEDICINES MAY INTERACT with Bortezomib . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Diabetes medicines (eg, glyburide, metformin) because the risk of high or low blood sugar may be increased
  • Alpha-blockers (eg, terazosin), medicines for high blood pressure, or any other medicines that may lower your blood pressure because the risk of low blood pressure and fainting may be increased. Ask your doctor or pharmacist if you are unsure if any of your medicines may lower your blood pressure

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bortezomib may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bortezomib :

Use Bortezomib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An additional patient leaflet is available with Bortezomib . Talk to your pharmacist if you have questions about this information.
  • Drinking fluids while you are using Bortezomib is recommended to prevent dehydration.
  • Bortezomib is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Bortezomib at home, carefully follow the proper mixing and injection procedures taught to you by your health care provider.
  • Do not use Bortezomib if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • It is very important that each dose is given at the scheduled time. If you miss a dose of Bortezomib , contact your doctor immediately to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Bortezomib .

Important safety information:

  • Bortezomib may cause dizziness, fatigue, fainting, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Bortezomib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Limit alcoholic beverages while taking Bortezomib .
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Bortezomib ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Bortezomib may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Use caution with sharp objects like safety razors or nail cutters and avoid activities, such as contact sports, to lower your chance of getting cut, bruised, or injured.
  • Bortezomib may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Carry an ID card at all times that says you take Bortezomib .
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Diabetes patients - Bortezomib may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Women of childbearing age should avoid becoming pregnant while being treated with Bortezomib . Be sure to use effective birth control while using Bortezomib .
  • Lab tests, including complete blood cell counts and platelet counts, may be performed while you use Bortezomib . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Bortezomib should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Bortezomib may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bortezomib while you are pregnant. It is not known if Bortezomib is found in breast milk. Do not breast-feed while using Bortezomib .

Possible side effects of Bortezomib :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred or double vision; constipation; diarrhea; dizziness; general body discomfort; headache; lightheadedness; loss of appetite; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; blindness or other vision changes; burning, numbness, pain, or tingling in the hands or feet; change in the amount of urine; chest pain; confusion; dark urine; dehydration; fainting; fast or irregular heartbeat; mental or mood changes (including thoughts of suicide); one-sided weakness; seizures; severe or persistent diarrhea or vomiting; severe or persistent headache; shortness of breath; signs of an infection (chills, fever, persistent sore throat, cough); slurred speech; stomach pain; sudden weight gain; swelling or pain in the ankles, feet, or legs; unusual bruising or bleeding; unusual tiredness or weakness; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include fainting; persistent fever.

Proper storage of Bortezomib :

Bortezomib is usually handled and stored by a health care provider. If you are using Bortezomib at home, store Bortezomib as directed by your pharmacist or health care provider. Keep Bortezomib out of the reach of children and away from pets.

General information:

  • If you have any questions about Bortezomib , please talk with your doctor, pharmacist, or other health care provider.
  • Bortezomib is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Bortezomib . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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