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|Bevacizumab Solution

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Bevacizumab Solution

Generic Name: Bevacizumab Injection Solution (beh-vah-SIH-zoo-mab)
Brand Name: Avastin

Bevacizumab Solution may rarely cause holes in the stomach or intestine that, in serious cases, may be fatal. Contact your doctor immediately if you develop unusual abdominal pain, constipation, and/or vomiting. Bevacizumab Solution may rarely cause the rupture or splitting of wounds. These complications may rarely be fatal. Use of Bevacizumab Solution is not recommended in patients who have had surgery in the last 28 days or in patients who have an incision that has not completely healed. Bevacizumab Solution may cause bleeding at tumor sites that may cause serious problems depending on the location of the tumor. Some patients treated with Bevacizumab Solution as part of their chemotherapy regimen for nonsmall cell lung cancer experienced coughing up of blood from the lungs that was serious and in some cases fatal. Use of Bevacizumab Solution is not recommended if you have recently experienced coughing up of blood. Discuss the risks and benefits of using Bevacizumab Solution with your doctor.

Bevacizumab Solution is used for:

Treating colon or rectal cancer that has spread to other parts of the body. It is used with other cancer medicines.

Bevacizumab Solution is a monoclonal antibody to vascular endothelial growth factor (VEGF). It blocks the formation and growth of new blood vessels in the tumor by targeting a protein called VEGF.

Do NOT use Bevacizumab Solution if:

you are allergic to any ingredient in Bevacizumab Solution
you have a history of coughing up blood, high blood pressure crisis, had surgery within the last 28 days, tear or hole in the stomach or intestine, or problems with wound healing or splitting

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bevacizumab Solution:

Some medical conditions may interact with Bevacizumab Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances, including mouse or murine proteins
if you have a history of high blood pressure, congestive heart failure, other heart problems, or blood clotting problems
if you have kidney problems, high amounts of protein in the urine, a wound that has not fully healed, or you are scheduled for surgery

Some MEDICINES MAY INTERACT with Bevacizumab Solution. However, no specific interactions with Bevacizumab Solution are known at this time. Tell your health care provider if you are taking any other medicines.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bevacizumab Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bevacizumab Solution:

Use Bevacizumab Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Bevacizumab Solution is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Bevacizumab Solution at home, carefully follow the injection procedures taught to you by your doctor.
If Bevacizumab Solution contains particles or if the vial is cracked or damaged in any way, do not use it.
Do not shake the medicine.
If you miss a dose of Bevacizumab Solution, contact your doctor immediately to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Bevacizumab Solution.

Important safety information:

If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Bevacizumab Solution.
LAB TESTS, including blood pressure measurements or certain tests that measure the amount of protein in your urine, may be required to monitor your progress and check for side effects. Be sure to keep all doctor and lab appointments.
Caution is advised when using Bevacizumab Solution in the ELDERLY because they may be more sensitive to its effects, especially the risk of blood clotting problems (eg, stroke, heart attack).
Bevacizumab Solution is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Bevacizumab Solution during pregnancy. Women should not become pregnant while using Bevacizumab Solution or for at least 20 days after the last treatment. It is unknown if Bevacizumab Solution is excreted in breast milk. Do not breast-feed while using Bevacizumab Solution or for a period of time after using Bevacizumab Solution. Contact your doctor for more information.

Possible side effects of Bevacizumab Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal walking; confusion; constipation; diarrhea; dizziness; dry mouth; dry skin; excess tearing; fainting; frequent or urgent urination; gas; hair loss; headache; indigestion; loss of appetite; muscle pain; nail disorder; pain; pain, swelling, or redness at the injection site; nausea; skin discoloration; skin irritation; skin lesion; sores or ulcers on the mouth or lips; stomach pain; taste change; tiredness; upper respiratory tract infection; voice change; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal pain with constipation and vomiting; black, tarry stools; calf pain or tenderness; cough; chest pain; confusion; coughing up or vomiting of blood; fever; loss of coordination; nosebleed; numbness of an arm or leg; numbness or loss of feeling; one-sided weakness; peeling of skin; severe or pounding headache; severe stomach pain; shortness of breath; sudden severe dizziness, vomiting, or fainting; swelling, discoloration, or pain in the legs; unusual bruising or bleeding; unusual weight gain; vision or speech changes; wounds that do not heal.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Bevacizumab Solution:

Store Bevacizumab Solution in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) before mixing. Protect from light. Do not freeze. After mixing, the medicine may be stored in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) for up to 8 hours. Discard any unused medicine immediately. Keep Bevacizumab Solution out of the reach of children and away from pets.

General information:

If you have any questions about Bevacizumab Solution, please talk with your doctor, pharmacist, or other health care provider.
Bevacizumab Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Bevacizumab Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006

Database Edition 06.4.1.002

Where can I get more information about Bevacizumab Solution ? We recommend to use www.Drugs.com

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