Betamethasone
 Betamethasone Cream,Lotion

drug-information.ru

|Betamethasone Betamethasone Cream,Lotion

Drugs search, click the first letter of a drug name:


| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9  Home

Betamethasone


Generic Name: Betamethasone dipropionate
Dosage Form: Lotion

Betamethasone Description

Betamethasone Dipropionate Lotion contains Betamethasone dipropionate, USP, a synthetic adrenocorticosteroid, for dermatologic use. Betamethasone, an analog of prednisolone, has high corticosteroid activity and slight mineralocorticoid activity. Betamethasone dipropionate is the 17,21‑dipropionate ester of Betamethasone.

Chemically, Betamethasone dipropionate is 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate.

It can be structurally represented as follows:

C28H37FO7 M.W. 504.6

Betamethasone dipropionate is a white to creamy white, odorless crystalline powder, insoluble in water.

Each gram of Betamethasone Dipropionate Lotion 0.05% w/w contains: 0.64 mg Betamethasone dipropionate, USP (equivalent to 0.5 mg Betamethasone) in a lotion base of isopropyl alcohol (47.5%) and purified water; slightly thickened with carbomer 934P; the pH is adjusted to approximately 4.7 with sodium hydroxide.

Betamethasone - Clinical Pharmacology

The corticosteroids are a class of compounds comprising steroid hormones, secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.

Topical corticosteroids, such as Betamethasone dipropionate, are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, antipruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Betamethasone dipropionate, a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. (See DOSAGE AND ADMINISTRATION.)

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. (See DOSAGE AND ADMINISTRATION.)

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Twenty-five pediatric patients ages 6 to 12 years, with atopic dermatitis, were enrolled in an open-label, hypothalamic-pituitary-adrenal (HPA) axis safety study. Betamethasone Dipropionate Lotion was applied twice daily for 2 to 3 weeks over a mean body surface area of 45% (range 35% to 72%). In 11 of 15 (73%) evaluable patients, adrenal suppression was indicated by either a ≤ 5 mcg/dL pre-stimulation cortisol, or a cosyntropin post-stimulation cortisol ≤ 18 mcg/dL and an increase of < 7 mcg/dL from the baseline cortisol. Studies performed with Betamethasone Dipropionate Lotion indicate that it is in the medium range of potency as compared with other topical corticosteroids.

Indications and Usage for Betamethasone

Betamethasone Dipropionate Lotion is a medium-potency corticosteroid indicated for relief of the inflammatory and pruritic manifestations of corticosteroid‑responsive dermatoses in patients 13 years and older.

Contraindications

Betamethasone Dipropionate Lotion is contraindicated in patients who are hypersensitive to Betamethasone dipropionate, to other corticosteroids, or to any ingredient in these preparations.

Precautions

General

Systemic absorption of topical corticosteroids has produced reversible hypothalamic‑pituitary‑adrenal (HPA) axis suppression, manifestations of Cushing"s syndrome, hyperglycemia, and glucosuria in some patients.

Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Use of more than one corticosteroid-containing product at the same time may increase total systemic glucocorticoid exposure. (See DOSAGE AND ADMINISTRATION.)

Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area should be evaluated periodically for evidence of HPA axis suppression by using the urinary-free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. In an open-label pediatric study of 15 evaluable patients, of the 11 subjects who showed evidence of suppression, 6 subjects were tested 2 weeks after discontinuation of Betamethasone Dipropionate Lotion, 0.05%, and 4 of the 6 (67%) had complete recovery of HPA axis function. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.

Pediatric patients may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity. (See PRECAUTIONS - Pediatric Use.)

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

Information for Patients

This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Patients using topical corticosteroids should receive the following information and instructions:

  1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
  2. Patients should be advised not to use this medication for any disorder other than that for which it was prescribed.
  3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive. (See DOSAGE AND ADMINISTRATION.)
  4. Patients should report any signs of local adverse reactions.
  5. Other corticosteroid-containing products should not be used with Betamethasone Dipropionate Lotion without first talking to your physician.

Laboratory Tests

The following tests may be helpful in evaluating HPA axis suppression:

Urinary-free cortisol test

ACTH stimulation test

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long‑term animal studies have not been performed to evaluate the carcinogenic potential of Betamethasone dipropionate.

Betamethasone was negative in the bacterial mutagenicity assay (Salmonella typhimurium and Escherichia coli), and in the mammalian cell mutagenicity assay (CHO/HGPRT). It was positive in the in-vitro human lymphocyte chromosome aberration assay, and equivocal in the in-vivo mouse bone marrow micronucleus assay. This pattern of response is similar to that of dexamethasone and hydrocortisone.

Reproductive studies with Betamethasone dipropionate carried out in rabbits at doses of 1.0 mg/kg by the intramuscular route and in mice up to 33 mg/kg by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species. These doses are approximately 0.5 and 4 fold the estimated maximum human dose based on a mg/m2 comparison, respectively.

Pregnancy

Teratogenic Effects

Pregnancy category C

Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels.

Betamethasone dipropionate has been shown to be teratogenic in rabbits when given by the intramuscular route at doses of 0.05 mg/kg. This dose is approximately 0.03 fold the estimated maximum human dose based on a mg/m2 comparison. The abnormalities observed included umbilical hernias, cephalocele and cleft palates.

Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Nursing Mothers

It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are prescribed for a nursing woman.

Pediatric Use

Use of Betamethasone Dipropionate Lotion, 0.05% in pediatric patients 12 years of age and younger is not recommended. (See CLINICAL PHARMACOLOGY and ADVERSE REACTIONS Sections.) In an open-label study, 11 of 15 (73%) evaluable pediatric patients (aged 6 years-12 years old) using Betamethasone Dipropionate Lotion for treatment of atopic dermatitis for 2-3 weeks demonstrated adrenal suppression. (See CLINICAL PHARMACOLOGY - Pharmacokinetics.)

Pediatric patients may demonstrate greater susceptibility to topical corticosteroid‑induced HPA axis suppression and Cushing"s syndrome than mature patients because of a larger skin surface area to body weight ratio.

Hypothalamic‑pituitary‑adrenal (HPA) axis suppression, Cushing"s syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.

Adverse Reactions

The following local adverse reactions are reported infrequently when Betamethasone Dipropionate Lotion is used as recommended in the DOSAGE AND ADMINISTRATION section. These reactions are listed in an approximate decreasing order of occurrence: burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria.

Adverse reactions reported to be possibly or probably related to treatment with Betamethasone Dipropionate Lotion during a pediatric study include: paresthesia (burning), erythema, erythematous rash, and dry skin. These adverse reactions each occurred in a different patient; 4% of the 25 patient population, respectively. An adverse reaction reported to be possibly or probably related to treatment in 2 different patients, 8%, of the 25 patients is pruritus.

Systemic absorption of topical corticosteroids has produced reversible hypothalamic‑pituitary‑adrenal (HPA) axis suppression, manifestations of Cushing"s syndrome, hyperglycemia, and glucosuria in some patients.

Overdosage

Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects. (See PRECAUTIONS.)

Betamethasone Dosage and Administration

Apply a few drops of Betamethasone Dipropionate Lotion to the affected area and massage lightly until it disappears. Apply twice daily, in the morning and at night. For the most effective and economical use, apply nozzle very close to affected area and gently squeeze bottle.

Betamethasone Dipropionate Lotion is not to be used with occlusive dressings.

If infection develops, appropriate antimicrobial therapy should be instituted.

How is Betamethasone Supplied

Betamethasone Dipropionate Lotion, USP 0.05% w/w is available in 60 mL plastic squeeze bottles.

Protect from light. Store in carton until contents are used.

Store at controlled room temperature, between 20° and 25°C (68° and 77°) (see USP).

Manufactured By:

TEVA PHARMACEUTICALS USA

Sellersville, PA 18960

Rev. M 4/2003


Betamethasone Dipropionate (Betamethasone Dipropionate)
PRODUCT INFO
Product Code 0093-0302 Dosage Form LOTION
Route Of Administration TOPICAL DEA Schedule
INGREDIENTS
Name (Active Moiety) Type Strength
Betamethasone Dipropionate (Betamethasone) Active 0.5 MILLIGRAM  In 1 MILLILITER
isopropyl alcohol Inactive  
water Inactive  
carbomer 934P Inactive  
sodium hydroxide Inactive  
IMPRINT INFORMATION
Characteristic Appearance Characteristic Appearance
Color Score
Shape Symbol
Imprint Code Coating
Size
PACKAGING
# NDC Package Description Multilevel Packaging
1 0093-0302-39 60 MILLILITER In 1 BOTTLE, PLASTIC None

Revised: 11/2006





Where can I get more information about Betamethasone Betamethasone Cream,Lotion ? We recommend to use www.Drugs.com

Typical mistypes for Betamethasone Betamethasone Cream,Lotion
vetamethasone betamethasone cream,lotion, netamethasone betamethasone cream,lotion, hetamethasone betamethasone cream,lotion, getamethasone betamethasone cream,lotion, bwtamethasone betamethasone cream,lotion, bstamethasone betamethasone cream,lotion, bdtamethasone betamethasone cream,lotion, brtamethasone betamethasone cream,lotion, b4tamethasone betamethasone cream,lotion, b3tamethasone betamethasone cream,lotion, beramethasone betamethasone cream,lotion, befamethasone betamethasone cream,lotion, begamethasone betamethasone cream,lotion, beyamethasone betamethasone cream,lotion, be6amethasone betamethasone cream,lotion, be5amethasone betamethasone cream,lotion, betzmethasone betamethasone cream,lotion, betsmethasone betamethasone cream,lotion, betwmethasone betamethasone cream,lotion, betqmethasone betamethasone cream,lotion, betanethasone betamethasone cream,lotion, betakethasone betamethasone cream,lotion, betajethasone betamethasone cream,lotion, betamwthasone betamethasone cream,lotion, betamsthasone betamethasone cream,lotion, betamdthasone betamethasone cream,lotion, betamrthasone betamethasone cream,lotion, betam4thasone betamethasone cream,lotion, betam3thasone betamethasone cream,lotion, betamerhasone betamethasone cream,lotion, betamefhasone betamethasone cream,lotion, betameghasone betamethasone cream,lotion, betameyhasone betamethasone cream,lotion, betame6hasone betamethasone cream,lotion, betame5hasone betamethasone cream,lotion, betametgasone betamethasone cream,lotion, betametbasone betamethasone cream,lotion, betametnasone betamethasone cream,lotion, betametjasone betamethasone cream,lotion, betametuasone betamethasone cream,lotion, betametyasone betamethasone cream,lotion, betamethzsone betamethasone cream,lotion, betamethssone betamethasone cream,lotion, betamethwsone betamethasone cream,lotion, betamethqsone betamethasone cream,lotion, betamethaaone betamethasone cream,lotion, betamethazone betamethasone cream,lotion, betamethaxone betamethasone cream,lotion, betamethadone betamethasone cream,lotion, betamethaeone betamethasone cream,lotion, betamethawone betamethasone cream,lotion, betamethasine betamethasone cream,lotion, betamethaskne betamethasone cream,lotion, betamethaslne betamethasone cream,lotion, betamethaspne betamethasone cream,lotion, betamethas0ne betamethasone cream,lotion, betamethas9ne betamethasone cream,lotion, betamethasobe betamethasone cream,lotion, betamethasome betamethasone cream,lotion, betamethasoje betamethasone cream,lotion, betamethasohe betamethasone cream,lotion, betamethasonw betamethasone cream,lotion, betamethasons betamethasone cream,lotion, betamethasond betamethasone cream,lotion, betamethasonr betamethasone cream,lotion, betamethason4 betamethasone cream,lotion, betamethason3 betamethasone cream,lotion, betamethasone vetamethasone cream,lotion, betamethasone netamethasone cream,lotion, betamethasone hetamethasone cream,lotion, betamethasone getamethasone cream,lotion, betamethasone bwtamethasone cream,lotion, betamethasone bstamethasone cream,lotion, betamethasone bdtamethasone cream,lotion, betamethasone brtamethasone cream,lotion, betamethasone b4tamethasone cream,lotion, betamethasone b3tamethasone cream,lotion, betamethasone beramethasone cream,lotion, betamethasone befamethasone cream,lotion, betamethasone begamethasone cream,lotion, betamethasone beyamethasone cream,lotion, betamethasone be6amethasone cream,lotion, betamethasone be5amethasone cream,lotion, betamethasone betzmethasone cream,lotion, betamethasone betsmethasone cream,lotion, betamethasone betwmethasone cream,lotion, betamethasone betqmethasone cream,lotion, betamethasone betanethasone cream,lotion, betamethasone betakethasone cream,lotion, betamethasone betajethasone cream,lotion, betamethasone betamwthasone cream,lotion, betamethasone betamsthasone cream,lotion, betamethasone betamdthasone cream,lotion, betamethasone betamrthasone cream,lotion, betamethasone betam4thasone cream,lotion, betamethasone betam3thasone cream,lotion, betamethasone betamerhasone cream,lotion, betamethasone betamefhasone cream,lotion, betamethasone betameghasone cream,lotion, betamethasone betameyhasone cream,lotion, betamethasone betame6hasone cream,lotion, betamethasone betame5hasone cream,lotion, betamethasone betametgasone cream,lotion, betamethasone betametbasone cream,lotion, betamethasone betametnasone cream,lotion, betamethasone betametjasone cream,lotion, betamethasone betametuasone cream,lotion, betamethasone betametyasone cream,lotion, betamethasone betamethzsone cream,lotion, betamethasone betamethssone cream,lotion, betamethasone betamethwsone cream,lotion, betamethasone betamethqsone cream,lotion, betamethasone betamethaaone cream,lotion, betamethasone betamethazone cream,lotion, betamethasone betamethaxone cream,lotion, betamethasone betamethadone cream,lotion, betamethasone betamethaeone cream,lotion, betamethasone betamethawone cream,lotion, betamethasone betamethasine cream,lotion, betamethasone betamethaskne cream,lotion, betamethasone betamethaslne cream,lotion, betamethasone betamethaspne cream,lotion, betamethasone betamethas0ne cream,lotion, betamethasone betamethas9ne cream,lotion, betamethasone betamethasobe cream,lotion, betamethasone betamethasome cream,lotion, betamethasone betamethasoje cream,lotion, betamethasone betamethasohe cream,lotion, betamethasone betamethasonw cream,lotion, betamethasone betamethasons cream,lotion, betamethasone betamethasond cream,lotion, betamethasone betamethasonr cream,lotion, betamethasone betamethason4 cream,lotion, betamethasone betamethason3 cream,lotion, betamethasone betamethasone xream,lotion, betamethasone betamethasone vream,lotion, betamethasone betamethasone fream,lotion, betamethasone betamethasone dream,lotion, betamethasone betamethasone ceeam,lotion, betamethasone betamethasone cdeam,lotion, betamethasone betamethasone cfeam,lotion, betamethasone betamethasone cteam,lotion, betamethasone betamethasone c5eam,lotion, betamethasone betamethasone c4eam,lotion, betamethasone betamethasone crwam,lotion, betamethasone betamethasone crsam,lotion, betamethasone betamethasone crdam,lotion, betamethasone betamethasone crram,lotion, betamethasone betamethasone cr4am,lotion, betamethasone betamethasone cr3am,lotion, betamethasone betamethasone crezm,lotion, betamethasone betamethasone cresm,lotion, betamethasone betamethasone crewm,lotion, betamethasone betamethasone creqm,lotion, betamethasone betamethasone crean,lotion, betamethasone betamethasone creak,lotion, betamethasone betamethasone creaj,lotion, betamethasone betamethasone cream,kotion, betamethasone betamethasone cream,potion, betamethasone betamethasone cream,ootion, betamethasone betamethasone cream,lition, betamethasone betamethasone cream,lktion, betamethasone betamethasone cream,lltion, betamethasone betamethasone cream,lption, betamethasone betamethasone cream,l0tion, betamethasone betamethasone cream,l9tion, betamethasone betamethasone cream,lorion, betamethasone betamethasone cream,lofion, betamethasone betamethasone cream,logion, betamethasone betamethasone cream,loyion, betamethasone betamethasone cream,lo6ion, betamethasone betamethasone cream,lo5ion, betamethasone betamethasone cream,lotuon, betamethasone betamethasone cream,lotjon, betamethasone betamethasone cream,lotkon, betamethasone betamethasone cream,lotoon, betamethasone betamethasone cream,lot9on, betamethasone betamethasone cream,lot8on, betamethasone betamethasone cream,lotiin, betamethasone betamethasone cream,lotikn, betamethasone betamethasone cream,lotiln, betamethasone betamethasone cream,lotipn, betamethasone betamethasone cream,loti0n, betamethasone betamethasone cream,loti9n, betamethasone betamethasone cream,lotiob, betamethasone betamethasone cream,lotiom, betamethasone betamethasone cream,lotioj, betamethasone betamethasone cream,lotioh, etamethasone betamethasone cream,lotion, btamethasone betamethasone cream,lotion, beamethasone betamethasone cream,lotion, betmethasone betamethasone cream,lotion, betaethasone betamethasone cream,lotion, betamthasone betamethasone cream,lotion, betamehasone betamethasone cream,lotion, betametasone betamethasone cream,lotion, betamethsone betamethasone cream,lotion, betamethaone betamethasone cream,lotion, betamethasne betamethasone cream,lotion, betamethasoe betamethasone cream,lotion, betamethason betamethasone cream,lotion, betamethasone betamethasone cream,lotion, betamethasone betamethasone cream,lotion, betamethasone etamethasone cream,lotion, betamethasone btamethasone cream,lotion, betamethasone beamethasone cream,lotion, betamethasone betmethasone cream,lotion, betamethasone betaethasone cream,lotion, betamethasone betamthasone cream,lotion, betamethasone betamehasone cream,lotion, betamethasone betametasone cream,lotion, betamethasone betamethsone cream,lotion, betamethasone betamethaone cream,lotion, betamethasone betamethasne cream,lotion, betamethasone betamethasoe cream,lotion, betamethasone betamethason cream,lotion, betamethasone betamethasonecream,lotion, betamethasone betamethasone ream,lotion, betamethasone betamethasone ceam,lotion, betamethasone betamethasone cram,lotion, betamethasone betamethasone crem,lotion, betamethasone betamethasone crea,lotion, betamethasone betamethasone creamlotion, betamethasone betamethasone cream,otion, betamethasone betamethasone cream,ltion, betamethasone betamethasone cream,loion, betamethasone betamethasone cream,loton, betamethasone betamethasone cream,lotin, betamethasone betamethasone cream,lotio, ebtamethasone betamethasone cream,lotion, bteamethasone betamethasone cream,lotion, beatmethasone betamethasone cream,lotion, betmaethasone betamethasone cream,lotion, betaemthasone betamethasone cream,lotion, betamtehasone betamethasone cream,lotion, betamehtasone betamethasone cream,lotion, betametahsone betamethasone cream,lotion, betamethsaone betamethasone cream,lotion, betamethaosne betamethasone cream,lotion, betamethasnoe betamethasone cream,lotion, betamethasoen betamethasone cream,lotion, betamethason e betamethasone cream,lotion, betamethasone betamethasone cream,lotion, betamethasone b etamethasone cream,lotion, betamethasone ebtamethasone cream,lotion, betamethasone bteamethasone cream,lotion, betamethasone beatmethasone cream,lotion, betamethasone betmaethasone cream,lotion, betamethasone betaemthasone cream,lotion, betamethasone betamtehasone cream,lotion, betamethasone betamehtasone cream,lotion, betamethasone betametahsone cream,lotion, betamethasone betamethsaone cream,lotion, betamethasone betamethaosne cream,lotion, betamethasone betamethasnoe cream,lotion, betamethasone betamethasoen cream,lotion, betamethasone betamethason ecream,lotion, betamethasone betamethasonec ream,lotion, betamethasone betamethasone rceam,lotion, betamethasone betamethasone ceram,lotion, betamethasone betamethasone craem,lotion, betamethasone betamethasone crema,lotion, betamethasone betamethasone crea,mlotion, betamethasone betamethasone creaml,otion, betamethasone betamethasone cream,oltion, betamethasone betamethasone cream,ltoion, betamethasone betamethasone cream,loiton, betamethasone betamethasone cream,lotoin, betamethasone betamethasone cream,lotino, bbetamethasone betamethasone cream,lotion, beetamethasone betamethasone cream,lotion, bettamethasone betamethasone cream,lotion, betaamethasone betamethasone cream,lotion, betammethasone betamethasone cream,lotion, betameethasone betamethasone cream,lotion, betametthasone betamethasone cream,lotion, betamethhasone betamethasone cream,lotion, betamethaasone betamethasone cream,lotion, betamethassone betamethasone cream,lotion, betamethasoone betamethasone cream,lotion, betamethasonne betamethasone cream,lotion, betamethasonee betamethasone cream,lotion, betamethasone betamethasone cream,lotion, betamethasone betamethasone cream,lotion, betamethasone bbetamethasone cream,lotion, betamethasone beetamethasone cream,lotion, betamethasone bettamethasone cream,lotion, betamethasone betaamethasone cream,lotion, betamethasone betammethasone cream,lotion, betamethasone betameethasone cream,lotion, betamethasone betametthasone cream,lotion, betamethasone betamethhasone cream,lotion, betamethasone betamethaasone cream,lotion, betamethasone betamethassone cream,lotion, betamethasone betamethasoone cream,lotion, betamethasone betamethasonne cream,lotion, betamethasone betamethasonee cream,lotion, betamethasone betamethasone cream,lotion, betamethasone betamethasone ccream,lotion, betamethasone betamethasone crream,lotion, betamethasone betamethasone creeam,lotion, betamethasone betamethasone creaam,lotion, betamethasone betamethasone creamm,lotion, betamethasone betamethasone cream,,lotion, betamethasone betamethasone cream,llotion, betamethasone betamethasone cream,lootion, betamethasone betamethasone cream,lottion, betamethasone betamethasone cream,lotiion, betamethasone betamethasone cream,lotioon, betamethasone betamethasone cream,lotionn, etc.



© Copyright by drug-information.ru 2001-2019. All rights reserved