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|Azacitidine

Azacitidine

Azacitidine is used for:

Treating certain cancers of the blood, including chronic myelomonocytic leukemia.

Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.

Do NOT use Azacitidine if:

• you are allergic to any ingredient in Azacitidine or to mannitol
• you have advanced liver cancer

Contact your doctor or health care provider right away if any of these apply to you.

Before using Azacitidine :

Some medical conditions may interact with Azacitidine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney or liver problems

Some MEDICINES MAY INTERACT with Azacitidine . However, no specific interactions with Azacitidine are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Azacitidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Azacitidine :

Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Azacitidine is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Azacitidine at home, carefully follow the injection procedures taught to you by your health care provider.
• Do not shake Azacitidine .
• If Azacitidine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• If Azacitidine comes into contact with the skin, immediately and thoroughly wash with soap and water. If it comes into contact with mucous membranes (eg, eyes, nose, mouth, vagina), flush thoroughly with water.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Azacitidine , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Azacitidine .

Important safety information:

• Azacitidine may cause dizziness, fainting, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Azacitidine . Using Azacitidine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Azacitidine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Azacitidine .
• Azacitidine may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
• Azacitidine may lower your body"s ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
• Men should not father a child while using Azacitidine . Talk with your doctor about using effective methods of birth control while using Azacitidine .
• LAB TESTS, including liver function tests, kidney function tests, and blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Azacitidine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Azacitidine may cause harm to the fetus. Avoid becoming pregnant while taking Azacitidine . If you think you may be pregnant, discuss with your doctor the benefits and risks of using Azacitidine during pregnancy. It is unknown if Azacitidine is excreted in breast milk. Do not breast-feed while taking Azacitidine .

Possible side effects of Azacitidine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; cough; diarrhea; dizziness; headache; joint or muscle pain; loss of appetite; nausea; redness at injection site; tiredness or weakness; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; chest pain; confusion; easy bruising or bleeding; decreased or painful urination; fainting; persistent fever, chills, or sore throat; stomach pain; swelling; unusual or severe tiredness; weight loss; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include diarrhea; nausea; vomiting.

Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.

General information:

• If you have any questions about this medicine, please talk with your doctor, pharmacist, or other health care provider.
• Azacitidine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Azacitidine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.