Avastin

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|Avastin

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BEVACIZUMAB (Systemic)

Some commonly used brand names are:

In the U.S.—

  • Avastin

Not commercially available in Canada.

Category

  • Antineoplastic monoclonal antibody
  • Vascular endothelial growth factor (VEGF) inhibitor

Description

Bevacizumab (be-va-SIZ-yoo-mab) is a substance that helps the body fight cancer. It prevents the growth of certain types of blood vessels to cancer cells. This helps to decrease the growth of cancer cells by starving the cells of nutrients needed to grow.

Bevacizumab is to be administered only by or under the immediate supervision of your doctor. It is available in the following dosage forms:

  • Parenteral
  • Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For bevacizumab, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to bevacizumab. Also tell your health care professional if you are allergic to any other substances such as foods, preservatives, or dyes.

Pregnancy—Bevacizumab has not been studied in pregnant women. However, studies in animals have shown that bevacizumab causes problems in both the mother and the child. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether bevacizumab passes into breast milk. However, bevacizumab is not recommended during breast feeding , because it may cause unwanted effects in nursing babies.

Children—Studies on this medicine have been done only in adult patients, and there is no information comparing use of bevacizumab in children with use in other age groups. However, studies of this medicine in animals have shown an increase in side effects.

Older adults—Specific side effects may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of bevacizumab.

Other medical problems—The presence of other medical problems may affect the use of bevacizumab. Be sure you tell your doctor if you have any other medical problems, especially:

  • Angina
  • Bleeding problems or
  • High blood pressure or
  • Heart attack or
  • Heart failure or
  • Hypersensitivity to bevacizumab or
  • Kidney problems or
  • Liver problems or
  • Protein in the urine or
  • Stroke or
  • Stomach/Intestinal problems or
  • Wound healing problems—May be worsened by bevacizumab

Proper Use of This Medicine

Dosing—Take this medicine only as directed by your doctor . Do not take more or less of it, and do not take it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition.

Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist , or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any medical work done.

Bevacizumab is often given together with certain other medicines. If you are using a combination of medicines, make sure that you take each one at the proper time and do not mix them. Ask your health care professional to help you plan a way to remember to take your medicines at the right times.

The dose of bevacizumab will be different for different patients. The dose that is used may depend on a number of things, including what the medicine is being used for, the patient"s size, and whether or not other medicines are also being taken.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from light
  • Store in the refrigerator. However, keep the medicine from freezing.

Precautions While Using This Medicine

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Other medicines: Do not take other medicines unless they have been discussed with your doctor.

Surgery: This medicine should not be taken within several weeks before or after surgery.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Black, tarry stools ; bleeding gums; body aches or pain; chest pain ; chills; cloudy urine; cough; cracks in the skin; convulsions; decreased urine output; dilated neck veins; ear congestion ; extreme fatigue; fever; high blood pressure; irregular breathing; irregular heartbeat; loss of appetite; loss of heat from the body; lack or loss of strength; loss of voice; mood changes; nasal congestion; pain; painful or difficult urination ; pinpoint red spots on skin; redness; runny nose; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; swelling of face, fingers, feet, or lower legs; troubled breathing; tightness in chest; unusual bleeding or bruising; unusual tiredness or weakness; vomiting of blood or material that looks like coffee grounds; watery or bloody diarrhea; weight gain; wheezing; yellow skin

Less common

Difficulty having a bowel movement (stool); fainting; stomach tenderness

Rare

Blisters; coma; confusion; convulsions; decreased urine output; increased thirst; muscle pain or cramps; open sores; pale skin; white spots on lips or in mouth

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Belching; bloody nose; change in walking and balance; clumsiness or unsteadiness; excess flow of tears; hair loss; heartburn; indigestion; low blood pressure; weight loss

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Hair loss; thinning of hair

Developed: 02/23/2005
Revised: 03/15/2006

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Typical mistypes for Avastin
zvastin, svastin, wvastin, qvastin, acastin, abastin, agastin, afastin, avzstin, avsstin, avwstin, avqstin, avaatin, avaztin, avaxtin, avadtin, avaetin, avawtin, avasrin, avasfin, avasgin, avasyin, avas6in, avas5in, avastun, avastjn, avastkn, avaston, avast9n, avast8n, avastib, avastim, avastij, avastih, vastin, aastin, avstin, avatin, avasin, avastn, avasti, vaastin, aavstin, avsatin, avatsin, avasitn, avastni, aavastin, avvastin, avaastin, avasstin, avasttin, avastiin, avastinn, etc.



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