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Lomocot, Lomotil, Lonox, |atropine and diphenoxylate

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atropine and diphenoxylate

Generic Name: atropine and diphenoxylate (A troe peen and dye fen OX i late)
Brand Names: Lomocot, Lomotil, Lonox

What is atropine and diphenoxylate?

Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines.

Diphenoxylate is an antidiarrheal medication.

The combination of atropine and diphenoxylate is used to treat diarrhea.

Atropine and diphenoxylate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about atropine and diphenoxylate?

If you are giving this medication to a child, pay close attention to the dose. Overdose is most likely in children who take this medication, even at recommended doses. An overdose of atropine and diphenoxylate can cause breathing problems and may result in death or permanent brain damage.

Use only the liquid form of this medicine in a child younger than 13 years old. Do not give atropine and diphenoxylate tablets to a child under 13.

Drink extra water while you are taking this medication to keep from getting dehydrated. It may take up to 48 hours of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 10 days of treatment. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol while you are taking this medication. Alcohol can increase some of the side effects of atropine and diphenoxylate.

What should I discuss with my healthcare provider before taking atropine and diphenoxylate?

Do not use this medication if you are allergic to atropine or diphenoxylate, or if you have:

jaundice (a liver disorder);
diarrhea that is caused by bacteria; or
diarrhea caused by taking an antibiotic.

Before taking atropine and diphenoxylate, tell your doctor if you are allergic to any drugs, or if you have:

blocked intestines;
an intestinal disorder such as ulcerative colitis or Crohn"s disease;
liver disease;
kidney disease;
heart disease, heart rhythm problems, or high blood pressure;
glaucoma;
Down"s syndrome;
a thyroid disorder;
problems with urination;
an enlarged prostate;
asthma or other lung problems; or
if you are dehydrated;

If you have any of these conditions, you may not be able to use atropine and diphenoxylate, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Atropine and diphenoxylate may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 2 years old.

How should I take atropine and diphenoxylate?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

If you are giving this medication to a child, pay close attention to the dose. Overdose is most likely in children who take this medication, even at recommended doses.

Use only the liquid form of this medicine in a child younger than 13 years old. Do not give atropine and diphenoxylate tablets to a child under 13.

Take this medicine with a full glass of water. Drink extra water while you are taking this medication to keep from getting dehydrated. It may take up to 48 hours of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 10 days of treatment.

Measure the liquid form of this medication with the marked medicine dropper provided, not a regular table spoon. If you do not have a medicine dropper, ask your pharmacist for one.

Store atropine and diphenoxylate at room temperature away from moisture and heat. Keep this medication away from children. An overdose of atropine and diphenoxylate can cause breathing problems and may result in death or permanent brain damage.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine, or if a child has accidentally swallowed it. An overdose of atropine and diphenoxylate can cause breathing problems and may result in death or permanent brain damage.

Early symptoms of an atropine and diphenoxylate overdose may include dry skin, dry mouth or nose, blurred vision, restless feeling, feeling too warm or cold, tingly feeling, and a fast heart rate

Progressing symptoms of an atropine and diphenoxylate overdose include weakness, pinpoint pupils in the eyes, weak or shallow breathing, fainting, or coma. Report any early overdose symptoms to your doctor as soon as possible.

What should I avoid while taking atropine and diphenoxylate?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol while you are taking this medication. Alcohol can increase some of the side effects of atropine and diphenoxylate.

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by atropine and diphenoxylate.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor"s instructions about the type and amount of liquids you should drink.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use atropine and diphenoxylate to stop the diarrhea unless your doctor has told you to.

Atropine and diphenoxylate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

stomach pain or bloating;
ongoing or worsening diarrhea;
diarrhea that is watery or bloody;
numbness in your hands or feet;
depressed mood;
confusion, unusual thoughts or behavior;
fast heart rate; or
urinating less than usual or not at all.

Keep taking atropine and diphenoxylate and talk to your doctor if you have any of these less serious side effects:

drowsiness, dizziness, headache;
tired or restless feeling;
nausea, vomiting, upset stomach, loss of appetite; or
skin rash, or itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect atropine and diphenoxylate?

Do not take this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take atropine and diphenoxylate before the MAO inhibitor has cleared from your body.

Before taking atropine and diphenoxylate, tell your doctor if you are using any of the following drugs:

a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

If you are using any of these drugs, you may not be able to use atropine and diphenoxylate, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect atropine and diphenoxylate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about atropine and diphenoxylate written for health professionals that you may read.

What does my medication look like?

Atropine and diphenoxylate is available with a prescription under the brand name Lomotil in tablets and liquid formulations. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Lomotil--round, white tablets containing 2.5 mg of diphenoxylate and 0.025 mg of atropine sulfate
Lomotil Liquid--2.5 mg of diphenoxylate and 0.025 mg of atropine sulfate per 5 mL (teaspoonful)

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 1.07. Revision Date: 1/11/07 4:32:29 PM.

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