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|Aprotinin

Aprotinin

Aprotinin is used for:

Reducing blood loss and the need for blood transfusions in patients undergoing certain types of heart surgery.

Aprotinin is a protease inhibitor. It works by reducing the inflammatory response associated with cardiopulmonary bypass surgery.

Do NOT use Aprotinin if:

• you are allergic to any ingredient in Aprotinin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aprotinin :

Some medical conditions may interact with Aprotinin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems
• if you have previously had heart surgery or have used Aprotinin before

Some MEDICINES MAY INTERACT with Aprotinin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril) or fibrinolytics (eg, streptokinase) because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aprotinin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aprotinin :

Use Aprotinin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Aprotinin is administered as an intravenous (IV; into a vein) injection only in a medical setting.
• Aprotinin comes with an additional patient leaflet. Read it carefully and reread it each time you get Aprotinin refilled.
• If you miss a dose of Aprotinin , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Aprotinin .

Important safety information:

• LAB TESTS may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Aprotinin is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Aprotinin during pregnancy. It is unknown if Aprotinin is excreted in breast milk. If you are or will be breast-feeding while you are using Aprotinin , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Aprotinin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; difficulty urinating; infection (fever, chills, sore throat); lightheadedness; sleeplessness; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); asthma; chest pain; confusion; decreased urination; fast or irregular heartbeat; lung disorder; nausea; numbness of an arm or leg; one-sided weakness; severe stomach pain; sudden severe headache, dizziness, fainting, or vomiting; sudden weight gain; swelling of the hands, legs, or feet; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800 -222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Aprotinin is usually handled and stored by a health care provider. Keep Aprotinin out of the reach of children and away from pets.

General information:

• If you have any questions about Aprotinin , please talk with your doctor, pharmacist, or other health care provider.
• Aprotinin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Aprotinin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.