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|Anistreplase |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home AnistreplasePronouncation: (uh-NISS-truh-place)Class: Thrombolytic Trade Names: Mechanism of ActionPharmacologyAids in dissolution of blood clots. PharmacokineticsMetabolismDeacylation of anistreplase forms lys-plasminogen-streptokinase activator complex (active). EliminationT ½ of fibrolytic activity is approximately 94 min. Indications and UsageLysis of obstructing coronary thrombi for management of acute MI. ContraindicationsHypersensitivity to streptokinase; active internal bleeding; history of cerebrovascular accident; recent (within 2 mo) intracranial or intraspinal surgery or trauma; intracranial neoplasm; arteriovenous malformation or aneurysm; known bleeding diathesis; uncontrolled hypertension. Dosage and AdministrationAdultsIV 30 units over 2 to 5 min into IV line or vein. Reconstitute powder with 5 mL of sterile water for injection. Do not shake vial during reconstitution; try to minimize foaming. Do not further dilute reconstituted anistreplase. Storage/StabilityStore lyophilized anistreplase under refrigeration. Discard any reconstituted anistreplase not administered within 30 min of reconstitution. Drug InteractionsAnticoagulants (eg, heparin, warfarin) and antiplatelet agents (eg, aspirin, dipyridamole)May increase risk of bleeding. IncompatibilityDo not add to any infusion fluids. Do not add other medications to vial or syringe containing anistreplase. Laboratory Test InteractionsCan cause decreases in plasminogen and fibrinogen levels and increases in thrombin time, activated PTT and PT, making results of coagulation tests unreliable. Adverse ReactionsCardiovascularArrhythmia and conduction disorders; hypotension. HematologicBleeding at puncture site, nonpuncture-site hematoma; hematuria; hemoptysis; GI hemorrhage; intracranial bleeding; mouth and gum hemorrhage; epistaxis; ocular hemorrhage; nonspecific hemorrhage. Precautions
PregnancyCategory C . LactationUndetermined. ChildrenSafety and efficacy not established. HypersensitivityRarely, anaphylactic and anaphylactoid reactions (with bronchospasm or angioedema) may occur. Arterial punctureIf arterial puncture is necessary after administration of anistreplase, it is preferable to use upper extremity vessel that is accessible to manual compression. Apply pressure dressing; check puncture site frequently for evidence of bleeding. Control minor bleeding with manual pressure. EpinephrineHave epinephrine and emergency treatment provisions available during administration of anistreplase. ReadministrationBecause of formation of antistreptokinase antibody, anistreplase may not be effective if administered more than 5 day to 6 mo after prior anistreplase or streptokinase therapy or after streptococcal infection. Patient Information
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