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|Anidulafungin

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ANIDULAFUNGIN (Systemic)†

Some commonly used brand names are:

In the U.S.—

Eraxis

† Not commercially available in Canada.

Description

Anidulafungin (ay-nid-yoo-la-FUN-jin) is an antifungal. It is used to help the body overcome serious fungus infections.

This medicine is available only with your doctor"s prescription, in the following dosage form:

Parenteral
Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For anidulafungin, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to anidulafungin. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Anidulafungin has not been studied in pregnant women. However, studies in animals have shown that anidulafungin causes birth defects or other problems. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether anidulafungin passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing the use of anidulafungin in children with use in other age groups.

Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of anidulafungin. Make sure you tell your doctor if you have any other medical problems, especially:

Allergies to other echinocandin antifungal drugs (Caspofungin [e.g., Cancidas], Micafungin [e.g., Mycamine])—You should not use anidulafungin.

Liver problems—This medicine may cause liver problems to become worse.

Proper Use of This Medicine

Dosing—The dose of anidulafungin will be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of anidulafungin.

For injection dosage form:
- Adults—At first, the dose is 200 milligrams (mg) injected into the vein. After that, the dose is 100 mg a day injected into a vein. For a fungal infection of the esophagus, the first dose is 100 mg and after that the dose is 50 mg a day.
- Children—Use and dose must be determined by your doctor.

Precautions While Using This Medicine

It is important that you adhere to your doctor"s treatment plan for you.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Black, tarry stools; chills; cough; decreased urine; dry mouth; fever; increased thirst; irregular heartbeat; loss of appetite; lower back or side pain; mood or mental changes; muscle pain or cramps; nausea or vomiting; numbness or tingling in hands, feet or lips; painful or difficult urination; pale skin; seizures; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; unusual bleeding or bruising; unusual tiredness or weakness

Rare

Abdominal or stomach pain; back pain; bleeding gums; blood in urine or stools; bloody stools; bluish color of skin; blurred or loss of vision; changes in skin color; chest pain; chest tightness; clay-colored stools; confusion; constipation; dark urine; depression; diarrhea; dizziness; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; drowsiness; extra heartbeats; fainting; fast heartbeat; fatigue; flushed, dry skin; flushing; fruit-like breath odor; headache; high blood pressure; hives or welts; incoherent speech; increased hunger; increased urination; infection of blood; irregular fast heartbeat; irritability; itching; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; light-colored stools; metallic taste; muscle spasms (tetany) or twitching; muscle weakness; nervousness; pain, redness or swelling in arm or leg; pain, tenderness, and swelling of foot or leg; palpitations; pinpoint red spots on skin; pounding in the ears; redness of skin; restlessness; skin rash; slow heartbeat; sore mouth or tongue; sweating; swelling of feet or lower legs; swollen glands; trembling; trouble breathing; unexplained weight loss; unpleasant breath odor; unusually warm skin; vomiting of blood; weakness; weight loss; white patches in the mouth or throat or on the tongue; white patches with diaper rash; yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

Rare

Acid or sour stomach; belching; bloating or swelling of face, arms, hands, lower legs, or feet; disturbed color perception; double vision; eye pain; feeling of warmth; feeling unusually cold; halos around light; hot flushes; indigestion; loss of bowel control; night blindness; over bright appearance of lights; rapid weight gain; redness of the face, neck, arms and occasionally, upper chest; shivering; stomach discomfort, upset, or pain; tingling of hands or feet; tunnel vision; unusual weight gain or loss; upper stomach pain

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 03/17/2006

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