|Anastrozole Anastrozole

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Generic name: Anastrozole
Brand names: Arimidex

Why is Anastrozole prescribed?

Anastrozole is a first-line treatment of breast cancer in postmenopausal women. It slows the growth of advanced cancer within the breast and cancer that has spread to other parts of the body. Anastrozole is also used to treat advanced breast cancer in postmenopausal women whose disease has spread to other parts of the body following treatment with tamoxifen (Nolvadex), another anticancer drug. Anastrozole can also be prescribed along with other drugs to treat the early stages of breast cancer in postmenopausal women.

Anastrozole combats the kind of breast cancer that thrives on estrogen. One of the hormones produced by the adrenal gland is converted to a form of estrogen by an enzyme called aromatase. Anastrozole suppresses this enzyme and thereby reduces the level of estrogen circulating in the body.

Most important fact about Anastrozole

Anastrozole, like many other anticancer medications, may prolong survival and improve quality of life. To keep Anastrozole working properly, it"s important to continue taking it even when you don"t feel well. If you develop bothersome side effects, call your doctor. He or she can recommend ways to reduce your discomfort.

How should you take Anastrozole?

Take Anastrozole exactly as directed.

--If you miss a dose...

Take the forgotten dose if you remember within 12 hours. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at once.

--Storage instructions...

Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Anastrozole.

  • More common side effects may include:
    Abdominal pain, accidental injury, anxiety, arthritis, back pain, bone pain, breast pain, cataracts, chest pain, constipation, cough, depression, diarrhea, dizziness, dry mouth, flu-like symptoms, fractures, headache, heart disease, high blood pressure or cholesterol, hot flashes, infection, insomnia, joint disease or pain, loss of appetite, nausea, osteoporosis, pain, pelvic pain and stiffness, "pins and needles", rash, shortness of breath, sore throat, stomach and intestinal upset, sweating, swelling of arms and legs, urinary tract infection, vaginal discharge or inflammation, vomiting, weakness, weight gain

Why should Anastrozole not be prescribed?

Do not take Anastrozole if you are pregnant or if you have an allergic reaction to the drug.

Special warnings about Anastrozole

Because Anastrozole may raise the level of cholesterol in your blood, your doctor may periodically do blood tests to check.

Possible food and drug interactions when taking Anastrozole

Certain drugs may decrease the effectiveness of Anastrozole, including tamoxifen (Nolvadex) and estrogen-containing drugs. Be sure to tell your doctor about any medication you are taking.

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, do not take Anastrozole. In animal studies, Anastrozole has caused severe birth defects, including incomplete bone formation and low birth weight; it could be poisonous to your unborn child. Anastrozole also increases your chances of having a miscarriage or a stillborn baby. If you should accidentally become pregnant, tell your doctor immediately.

Because of the possibility of Anastrozole passing through your breast milk to your baby, you should probably avoid breastfeeding.

Recommended dosage


The usual dose is a 1-milligram tablet taken once a day. If Anastrozole is being used as an initial treatment for advanced breast cancer, you will continue taking the medication until it no longer works against the tumor. The optimal duration of therapy for early breast cancer has not been determined.


Although there have been no reports of Anastrozole overdose, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

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