Agrylin, |anagrelide Anagrelide

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Generic Name: anagrelide (an AH greh lide)
Brand Names: Agrylin

What is anagrelide?

Anagrelide lowers the number of blood clotting cells (called platelets) in the body. This helps to prevent blood clots from forming.

Anagrelide is used to treat essential thrombocytosis (too many blood clotting cells in the body).

Anagrelide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about anagrelide?

Your doctor will need to monitor your blood with blood tests before starting treatment with anagrelide, every 2 days for the first week of treatment, and at least weekly thereafter until the desired maintenance dosage is reached.

Tell your doctor and dentist that you are taking this medication before undergoing any surgical procedures.

Who should not take anagrelide?

Before taking anagrelide, tell your doctor if you have

  • heart disease,

  • kidney disease, or
  • liver disease.

You may not be able to take anagrelide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Anagrelide is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether anagrelide passes into breast milk. Do not take this medication without first talking to your doctor if you are breast feeding a baby. Anagrelide is not approved for use by children younger than 16 years old.

How should I take anagrelide?

Take anagrelide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Your doctor will need to monitor your blood with blood tests before starting treatment with anagrelide, every 2 days for the first week of treatment, and at least weekly thereafter until the desired maintenance dosage is reached.

Store anagrelide at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a anagrelide overdose are unknown but might include bleeding and blood in the vomit or stool.

What should I avoid while taking anagrelide?

Tell your doctor and dentist that you are taking this medication before undergoing any surgical procedures.

Anagrelide side effects

If you experience any of the following serious side effects, stop taking anagrelide and seek emergency medical attention or notify your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • fast, slow, or irregular heartbeat;

  • chest pain;

  • swelling of the hands, feet, or legs;

  • shortness of breath or difficulty in breathing;

  • seizures;

  • bloody or black vomit or stools;

  • abdominal pain;

  • unusual, prolonged, or severe bleeding or bruising; or

  • a bleeding nose.

Other, less serious side effects may also occur. Continue to take anagrelide and talk to your doctor if you experience

  • headache;

  • diarrhea;

  • tingling or numbness in the hands or feet;

  • upset stomach, nausea, or vomiting;

  • dizziness;

  • gas;

  • fever;

  • a rash or itching;

  • loss of appetite;

  • sore throat;

  • cough; or

  • back pain.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect anagrelide?

There are no known interactions between anagrelide and other medicines. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has more information about anagrelide written for health professionals that you may read.

What does my medication look like?

Anagrelide is available with a prescription under the brand name Agrylin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Agrylin 0.5 mg--opaque, white, capsules

  • Agrylin 1 mg-opaque, gray capsules

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ("Multum") is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum"s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum"s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 2/13/04 4:06:54 PM.

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