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|Anagrelide

Anagrelide

Anagrelide is used for:

Treating patients with high blood platelet levels (thrombocythemia) due to bone marrow problems. It may also be used for other conditions as determined by your doctor.

Anagrelide is a platelet-reducing agent. It works by decreasing the body"s production of platelets, which helps to prevent blood clots.

Do NOT use Anagrelide if:

• you are allergic to any ingredient in Anagrelide
• you have severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Anagrelide :

Some medical conditions may interact with Anagrelide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have heart, liver, or kidney disease

Some MEDICINES MAY INTERACT with Anagrelide . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sucralfate because the effectiveness of Anagrelide may be decreased
• Amrinone, aspirin, cilostazol, enoximone, milrinone, or olprinone because actions and side effects may be increased by Anagrelide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Anagrelide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Anagrelide :

Use Anagrelide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Anagrelide may be taken on an empty stomach or with food.
• If you miss a dose of Anagrelide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anagrelide .

Important safety information:

• Anagrelide may cause drowsiness, dizziness, or vision changes. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Anagrelide . Using Anagrelide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Anagrelide may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Anagrelide may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Anagrelide . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Anagrelide may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Anagrelide .
• LAB TESTS, including liver function, kidney function, blood pressure, and blood counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: Anagrelide may cause harm to the fetus. Avoid becoming pregnant while taking Anagrelide . If you think you may be pregnant, contact your doctor immediately. It is unknown if Anagrelide is excreted in breast milk. Do not breast feed while taking Anagrelide .

Possible side effects of Anagrelide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; cough; diarrhea; dizziness; drowsiness; gas; general body discomfort; headache; joint or muscle weakness; loss of appetite; nausea; stomach pain; tiredness; upset stomach; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine, stools, or vomit; changes in vision; chest pain, especially if sharp or crushing; depression; easy bruising or bleeding; fainting; fast or irregular heartbeat; flu-like symptoms (eg, sore throat, fever, or chills); memory loss; mental or mood changes; numbness or tingling of your skin or of an arm or leg; one-sided weakness; pounding in the chest; seizures; severe stomach pain; sudden leg pain; sudden severe headache, vomiting, dizziness, or fainting; sudden shortness of breath; swelling of the hands, legs, or feet; trouble urinating.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include unusual bleeding and bruising.

Store Anagrelide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anagrelide out of the reach of children and away from pets.

General information:

• If you have any questions about Anagrelide , please talk with your doctor, pharmacist, or other health care provider.
• Anagrelide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Anagrelide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.