drug-information.ru

|Aminosalicylate Sodium

Drugs search, click the first letter of a drug name:

| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home

Aminosalicylate Sodium

( Para-Aminosalicylate Sodium ; PAS ) Pronouncation: (uh-MEE-no-suh-LIS-ih-late SO-dee-uhm)
Class: Antituberculosis agent

Trade Names:
Paser
- Granules, delayed-release 4 g

Mechanism of Action

Pharmacology

Competitively antagonizes metabolism of para-aminobenzoic acid, resulting in bacteriostatic activity against Mycobacterium tuberculosis .

Pharmacokinetics

Absorption

T _max is about 6 h; C _max is about 20 mcg/mL.

Distribution

About 50% to 60% is protein bound.

Elimination

80% is excreted in the urine with at least 50% excreted in acetylated form. The t _1/2 of free aminosalicylic acid is 26.4 min.

Special Populations

Renal Function Impairment

Drug and its acetyl metabolite may accumulate.

Indications and Usage

Treatment of tuberculosis (in combination with other antituberculous drugs) caused by susceptible strains of tubercle bacilli.

Contraindications

Severe hypersensitivity to aminosalicylate sodium and its congeners.

Dosage and Administration

Adults and Children

PO 150 mg/kg (max, 12 g/day).

General Advice

Sprinkle granules on acidic food or drink.
Do not use products that are brown or purple in color.

Drug Interactions

Digoxin

May reduce oral absorption and serum levels of digoxin.

Rifampin

May decrease absorption of rifampin.

Vitamin B ₁₂

May decrease GI absorption of oral vitamin B ₁₂ .

Laboratory Test Interactions

None well documented.

Adverse Reactions

GI

Nausea; vomiting; diarrhea; abdominal pain.

Metabolic

Goiter with or without myxedema.

Miscellaneous

Hypersensitivity (eg, fever, skin eruptions, infectious mononucleosis-like syndrome, leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, jaundice, hepatitis, encephalopathy, Loffler syndrome, vasculitis).

Precautions

Pregnancy

Category C .

Lactation

Excreted in breast milk.

Hypersensitivity

Stop medication if hypersensitivity symptoms develop. Restart cautiously.

Renal Function

Use with caution.

Hepatic Function

Use with caution.

CHF

Use with caution because of high sodium content (55 mg of sodium per 500 mg tablet).

Crystalluria

Maintain urine at neutral or alkaline pH to avoid crystalluria.

Gastric ulcer

Use with caution.

Patient Information

Instruct patient to take medication with meals or immediately after meals to minimize GI symptoms, and to maintain adequate fluid intake.
Explain to patient taking digoxin that dose may be increased while taking aminosalicylate sodium.
Instruct patient to report the following symptoms to health care provider: fever, sore throat, unusual bleeding or bruising, rash.
Teach patient importance of maintaining urine at neutral or alkaline pH and demonstrate method for testing urine pH.

Where can I get more information about Aminosalicylate Sodium ? We recommend to use www.Drugs.com

Typical mistypes for Aminosalicylate Sodium
zminosalicylate sodium, sminosalicylate sodium, wminosalicylate sodium, qminosalicylate sodium, aninosalicylate sodium, akinosalicylate sodium, ajinosalicylate sodium, amunosalicylate sodium, amjnosalicylate sodium, amknosalicylate sodium, amonosalicylate sodium, am9nosalicylate sodium, am8nosalicylate sodium, amibosalicylate sodium, amimosalicylate sodium, amijosalicylate sodium, amihosalicylate sodium, aminisalicylate sodium, aminksalicylate sodium, aminlsalicylate sodium, aminpsalicylate sodium, amin0salicylate sodium, amin9salicylate sodium, aminoaalicylate sodium, aminozalicylate sodium, aminoxalicylate sodium, aminodalicylate sodium, aminoealicylate sodium, aminowalicylate sodium, aminoszlicylate sodium, aminosslicylate sodium, aminoswlicylate sodium, aminosqlicylate sodium, aminosakicylate sodium, aminosapicylate sodium, aminosaoicylate sodium, aminosalucylate sodium, aminosaljcylate sodium, aminosalkcylate sodium, aminosalocylate sodium, aminosal9cylate sodium, aminosal8cylate sodium, aminosalixylate sodium, aminosalivylate sodium, aminosalifylate sodium, aminosalidylate sodium, aminosalictlate sodium, aminosalicglate sodium, aminosalichlate sodium, aminosaliculate sodium, aminosalic7late sodium, aminosalic6late sodium, aminosalicykate sodium, aminosalicypate sodium, aminosalicyoate sodium, aminosalicylzte sodium, aminosalicylste sodium, aminosalicylwte sodium, aminosalicylqte sodium, aminosalicylare sodium, aminosalicylafe sodium, aminosalicylage sodium, aminosalicylaye sodium, aminosalicyla6e sodium, aminosalicyla5e sodium, aminosalicylatw sodium, aminosalicylats sodium, aminosalicylatd sodium, aminosalicylatr sodium, aminosalicylat4 sodium, aminosalicylat3 sodium, aminosalicylate aodium, aminosalicylate zodium, aminosalicylate xodium, aminosalicylate dodium, aminosalicylate eodium, aminosalicylate wodium, aminosalicylate sidium, aminosalicylate skdium, aminosalicylate sldium, aminosalicylate spdium, aminosalicylate s0dium, aminosalicylate s9dium, aminosalicylate sosium, aminosalicylate soxium, aminosalicylate socium, aminosalicylate sofium, aminosalicylate sorium, aminosalicylate soeium, aminosalicylate soduum, aminosalicylate sodjum, aminosalicylate sodkum, aminosalicylate sodoum, aminosalicylate sod9um, aminosalicylate sod8um, aminosalicylate sodiym, aminosalicylate sodihm, aminosalicylate sodijm, aminosalicylate sodiim, aminosalicylate sodi8m, aminosalicylate sodi7m, aminosalicylate sodiun, aminosalicylate sodiuk, aminosalicylate sodiuj, minosalicylate sodium, ainosalicylate sodium, amnosalicylate sodium, amiosalicylate sodium, aminsalicylate sodium, aminoalicylate sodium, aminoslicylate sodium, aminosaicylate sodium, aminosalcylate sodium, aminosaliylate sodium, aminosaliclate sodium, aminosalicyate sodium, aminosalicylte sodium, aminosalicylae sodium, aminosalicylat sodium, aminosalicylatesodium, aminosalicylate odium, aminosalicylate sdium, aminosalicylate soium, aminosalicylate sodum, aminosalicylate sodim, aminosalicylate sodiu, mainosalicylate sodium, aimnosalicylate sodium, amniosalicylate sodium, amionsalicylate sodium, aminsoalicylate sodium, aminoaslicylate sodium, aminoslaicylate sodium, aminosailcylate sodium, aminosalciylate sodium, aminosaliyclate sodium, aminosaliclyate sodium, aminosalicyalte sodium, aminosalicyltae sodium, aminosalicylaet sodium, aminosalicylat esodium, aminosalicylates odium, aminosalicylate osdium, aminosalicylate sdoium, aminosalicylate soidum, aminosalicylate soduim, aminosalicylate sodimu, aaminosalicylate sodium, amminosalicylate sodium, amiinosalicylate sodium, aminnosalicylate sodium, aminoosalicylate sodium, aminossalicylate sodium, aminosaalicylate sodium, aminosallicylate sodium, aminosaliicylate sodium, aminosaliccylate sodium, aminosalicyylate sodium, aminosalicyllate sodium, aminosalicylaate sodium, aminosalicylatte sodium, aminosalicylatee sodium, aminosalicylate sodium, aminosalicylate ssodium, aminosalicylate soodium, aminosalicylate soddium, aminosalicylate sodiium, aminosalicylate sodiuum, aminosalicylate sodiumm, etc.