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Some commonly used brand names are:

In the U.S.—

  • Allegra-D
  • Allegra-D 24 Hour


  • Antihistamine (H 1 -receptor)-decongestant


Fexofenadine (fex-oh-FEN-a-deen) is an antihistamine and pseudoephedrine (soo-doe-e-FED-rin) is a decongestant. The combination of these two medicines is used to treat the nasal congestion (stuffy nose), sneezing, and runny nose caused by hay fever.

This medicine is available only with your doctor"s prescription, in the following dosage forms:

  • Oral
  • Extended-release tablets [12 hour] (U.S.)
  • Extended-release tablets [24 hour] (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fexofenadine and pseudoephedrine combination, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to fexofenadine or pseudoephedrine, or to amphetamine, dextroamphetamine (e.g., Dexedrine), ephedrine (e.g., Ephed II), epinephrine (e.g., Adrenalin), isoproterenol (e.g., Isuprel), metaproterenol (e.g., Alupent), methamphetamine (e.g., Desoxyn), norepinephrine (e.g., Levophed), phenylephrine (e.g., Neo-Synephrine), phenylpropanolamine (e.g., Dexatrim), or terbutaline (e.g., Brethine). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—In animal studies, this medicine did not cause birth defects but did cause a decrease in weight of newborn and bone formation in the ribs. Discuss with your doctor whether or not you should continue to use this medicine if you become pregnant.

Breast-feeding—It is not known whether fexofenadine passes into breast milk, but pseudoephedrine does pass into breast milk. Discuss with your doctor the risks of breast-feeding while taking this medicine.

Children—Use is not recommended in infants and children up to 12 years of age. In children 12 years of age and older, this medicine is not expected to cause different side effects or problems than it does in adults.

Older adults—Some side effects may be more likely to occur in elderly patients, who are usually more sensitive to the effects of this medicine.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your health care professional know if you are taking any of the following:

  • Antacids that contain magnesium or aluminum (e.g., Maalox)—May decrease the amount of fexofenadine in your body. This medication should not be taken closely in time with antacids containing magnesium or aluminum.
  • Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegiline [e.g., Eldepryl], tranylcypromine [e.g., Parnate])—If you are now taking, or have taken within the past 2 weeks, any of the MAO inhibitors, the side effects of pseudoephedrine may become more severe; these medicines should not be used together

Other medical problems—The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diabetes mellitus (sugar diabetes)—Use of this medicine may cause an increase in blood glucose levels
  • Enlarged prostate or
  • Urinary tract blockage or difficult urination—Use of this medicine may cause urination to be more difficult. You should not take this medicine if you have these conditions.
  • Glaucoma or
  • Increased pressure in the eye—Use of this medicine may make the condition worse. You should not take this medicine if you have these conditions.
  • Heart or blood vessel disease or
  • High blood pressure—Use of this medicine may make the condition worse. You should not take this medicine if you have high blood pressure, especially if it is severe.
  • Kidney disease—Effects may be increased because of slower removal of the medicine from the body. The 24-hour extended-release tablet should not be used if you have kidney problems.
  • Overactive thyroid—Serious effects on the heart may occur

Proper Use of This Medicine

Swallow the extended-release tablet whole. Do not crush, break, or chew it before swallowing.

This medicine is best taken on an empty stomach (either one hour before or two hours after a meal).

This medicine should be taken with water. Do not take with fruit juices or antacids.

Dosing—The dose of this medicine may be different for different patients. Follow your doctor"s orders or the directions on the label . The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

  • For oral dosage form (extended-release tablets [12 hour]):
    • For symptoms of hay fever:
      • Adults and teenagers—1 tablet two times a day.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (extended-release tablets [24 hour]):
    • For symptoms of hay fever:
      • Adults and teenagers—1 tablet one time a day.
      • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light in a tightly closed container.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Trouble in sleeping

Less common

Cough; dizziness; irregular heartbeat; nervousness; sore throat

Incidence not known

Difficult or labored breathing; difficulty swallowing; dizziness; fast heartbeat; feeling of warmth; fever; hives or welts; itching skin; itching, puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs; reddening of the skin, especially around ears; redness of the face, neck, arms and occasionally, upper chest; shortness of breath; skin rash; tightness in chest; swelling of eyes, face, or inside of nose; unusual tiredness or weakness; wheezing

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Headache; nausea

Less common

Abdominal or stomach pain; agitation; anxiety; back pain; dry mouth; heartburn

Incidence not known

Terrifying dreams causing sleep disturbances

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 08/12/1998
Revised: 01/06/2005

The information contained in the Thomson Healthcare (Micromedex) products as delivered by is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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