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|Alitretinoin |
Drugs search, click the first letter of a drug name: | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 1 | 2 | 3 | 4 | 5 | 6 | 8 | 9 Home AlitretinoinPronouncation: (al-ih-TRET-ih-no-in)Class: Second generation retinoid Trade Names: Mechanism of ActionPharmacologyBinds to and activates all known intracellular retinoid receptor substrates. Once activated, these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation of both normal and neoplastic cells. PharmacokineticsAbsorptionIndirect evidence indicates that absorption is not extensive. Plasma levels are similar to circulating, naturally occurring 9-cis-retinoic acid levels. Indications and UsageTopical treatment of cutaneous lesions of AIDS-related Kaposi sarcoma (KS). ContraindicationsHypersensitivity to retinoids or any component of the product. Dosage and AdministrationAdultsTopical Start with twice-daily application to KS lesions. Application can be gradually increased to 3 or 4 times daily or reduced according to individual lesion tolerance or application site toxicity. If severe irritation occurs, application of drug can be temporarily stopped for a few days until symptoms subside. Apply a sufficient amount of gel to cover the lesion with a generous coating. Allow to dry for 3 to 5 min before covering with clothing. A response to KS lesions may be seen as soon as 2 wk; however, some patients have required over 14 wk. General Advice
Storage/StabilityStore gel at controlled room temperature (59° to 86°F). Keep tube tightly capped. Drug InteractionsN,N-diethyl-m-toluamide (DEET)Avoid concurrent use of products containing DEET (a common component of insect repellents). Laboratory Test InteractionsNone well documented. Adverse ReactionsDermatologicRash (77%); pain (34%); pruritus (11%); exfoliative dermatitis (9%); edema, skin disorder (including excoriation, cracking, scab, crusting, drainage, eschar, fissure, oozing [8%]); paresthesia (3%). PrecautionsPregnancyCategory D . Could cause fetal harm if absorption were to occur in pregnant women. LactationUndetermined. ChildrenSafety and efficacy not established. PhotosensitivityMay occur with this class of agent; avoid excessive sunlight and ultraviolet light. Coadministration of topical productsDo not apply other topical products unless advised by health care provider. Assess the skin and identify areas where medication is to be applied and areas that should be avoided (eg, healthy skin). SystemicDo not use gel on patient who requires systemic anti-KS therapy (eg, more than 10 new KS lesions in prior month, symptomatic pulmonary KS, symptomatic visceral involvement). Patient Information
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