Advate

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Advate


Generic Name: Antihemophilic Factor (Recombinant) Plasma/Albumin Free (ann-tie-HEE-moe-FIH-lic)
Brand Name: Advate

Advate is used for:

Preventing and controlling bleeding in patients with hemophilia A (factor VIII deficiency), including in surgical settings.

Advate is a man-made clotting factor. It works by increasing the amount of clotting factor VIII in the body, which helps the blood clot normally.

Do NOT use Advate if:

  • you are allergic to any ingredient in Advate , including mouse or hamster proteins

Contact your doctor or health care provider right away if any of these apply to you.

Before using Advate :

Some medical conditions may interact with Advate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have Von Willebrand disease

Some MEDICINES MAY INTERACT with Advate . However, no specific interactions with Advate are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Advate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Advate :

Use Advate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An additional patient leaflet is available with Advate . Talk to your pharmacist if you have questions about this information.
  • Advate is usually administered as an injection at your doctor"s office, hospital, or clinic. If you are using Advate at home, carefully follow the injection procedures taught to you by your health care provider.
  • Your doctor or other health care provider will give you detailed instructions on how to mix and administer Advate if you will be using it at home. Instructions are also included in the patient leaflet that is available with Advate . Be sure you understand how to give Advate before you administer a dose. If you have any questions or concerns, contact your doctor or other health care provider.
  • If Advate contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • When drawing a dose into a syringe, be sure to follow the procedure demonstrated to you by your doctor to prevent contamination of the vial, syringe, or medicine. Never touch the rubber stopper of the vial or the needle of the syringe with your fingers.
  • Carefully check that you have drawn the correct dose before administration.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Advate , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Advate .

Important safety information:

  • Advate may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Advate . Using Advate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Patients receiving clotting factors sometimes develop antibodies or inhibitors to the medicine. This makes it less effective. If Advate stops working or does not work as well as it has before, contact your doctor immediately for instructions.
  • Lab tests, including factor VIII levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Advate can cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Advate during pregnancy. If you are or will be breast-feeding while you are using Advate , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Advate :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; headache; joint pain; pain, swelling, or redness at the injection site; sore throat; stuffy nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fever; severe headache; unusual bruising.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Advate :

Store Advate in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. You may also store Advate at room temperature, below 86 degrees F (30 degrees C), for up to 6 months. Once Advate has been kept at room temperature, do not return it to the refrigerator. Do not use Advate if the expiration date on the product has passed. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Advate out of the reach of children and away from pets.

General information:

  • If you have any questions about Advate , please talk with your doctor, pharmacist, or other health care provider.
  • Advate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Advate . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: November 1, 2006
Database Edition 06.4.1.002
Copyright © 2006 Wolters Kluwer Health, Inc.




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